Discovery Leads to Earlier Diagnosis of Type 1 Diabetes

Researchers identify molecular signature in human type 1 diabetes

Apr 16, 2008, 01:00 ET from Children's Hospital of Wisconsin

    MILWAUKEE, April 16 /PRNewswire/ -- Researchers at Children's Research
 Institute, located in Milwaukee, recently made significant discoveries in
 juvenile diabetes diagnosis. Led by Martin Hessner, PhD, associate
 professor, Medical College of Wisconsin, the research team applied a new
 approach, finding that type 1 diabetes patients during the honeymoon phase
 create a unique genomic fingerprint. The research team used a new type of
 blood test that identifies inflammation associated with type 1 diabetes
 though a unique genomic fingerprint. Remarkably, this fingerprint is
 evident years prior to disease onset. This discovery offers insight into
 the pathways responsible for type 1 diabetes. This fingerprint will be
 useful in identifying at-risk children earlier in the disease process. This
 offers hope for earlier treatment and even delay or prevention of
 full-blown diabetes. The Journal of Immunology recently published this
     This research was accomplished through the Max McGee National Research
 Center for Juvenile Diabetes, established by football legend Max McGee.
 Diabetes is prevalent in the McGee family. Max's brother fought diabetes in
 his lifetime, and today, the McGees' son, Dallas, lives every day with this
 life-threatening disease. The late McGee, who died last October, co-founded
 the center to find a cure not only for his son, but for all people living
 with type 1 diabetes.
     The center is one of few in the world studying the role of genetics in
 childhood diabetes. While diabetes is prevalent in some families, like the
 McGees, only 10 percent of newly diagnosed cases occur in families where
 that history exists. The Diabetes Program at Children's Hospital of
 Wisconsin is one of the largest in the country, serving more than 1,700
 children with type 1 and type 2 diabetes and their families.
     About Children's Research Institute
     Children's Research Institute advances state-of-the-art pediatric
 health care practice through dedicated laboratory and clinical research.
 Based on the concept of translational research, the institute is designed
 to take clinical problems from patients' bedsides to study in the
 laboratory. Laboratory discoveries are then converted into new treatments,
 preventions, therapies and cures for patients. Children's Research
 Institute is affiliated with Children's Hospital of Wisconsin and is a
 member of Children's Hospital and Health System. The health system is able
 to fulfill its mission thanks in part to philanthropic gifts and support
 from members of the community. For more information visit the Web site at

SOURCE Children's Hospital of Wisconsin