Global Markets for Chiral Technology -- Focus on the U.S.
NEW YORK, May 31, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Global Markets for Chiral Technology -- Focus on the U.S.
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INTRODUCTION
STUDY OBJECTIVES
BCC's goal in conducting this study is to provide an overview of the current and future global market for chiral products and technologies used in today's world. The key objective is to present a comprehensive analysis of the current market and its future direction in the chiral market as an important tool in various therapeutic industries and other industries.
This report explores present and future strategies within the chiral market, including the synthesis, separation and analysis of chiral products. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. An overview of chirality, and the chiral products and technologies used in the past and currently are discussed in this report.
A detailed analysis of the structure of the chiral industry has been conducted. This includes chiral synthesis, chiral separation/resolution and chiral analysis. Revenues are broken down by global region from 2009 to 2011 and estimated for the five-year period from 2011 through 2016.
Applications for chiral products and technologies are also discussed in this report, with an emphasis on the usage in the pharmaceutical, biochemical and agrochemical industries. The report also covers significant patents and their allotment in each category.
REASONS FOR DOING THIS STUDY
This study was conducted to provide an update of new developments in the chiral technology market. The current study covers the global market for chiral products, with a specific focus on the U.S. markets, European markets and emerging markets. This study was conducted to provide a detailed market analysis of chiral-enabling products, including the factors influencing this market. New advancements and the need for enantiopure compounds have driven growth within this market. This study looks at most of the systems influenced by these factors.
Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each system/technology in light of the new technologies, growing competition and changing customer needs.
INTENDED AUDIENCE
This study contributes to the areas of market growth in therapeutic segments through chiral products and technologies from the point of view of manufacturers and users. The pharmaceutical and biopharmaceutical industries, agrochemical industries, physicians, hospitals and research institutes will find this study to be of interest.
SCOPE OF THE STUDY
The scope of this study encompasses the chiral markets with their usage in the pharmaceutical, biotechnical and agrochemical markets. BCC analyzes each market and its applications by its need for chiral products, their regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.
METHODOLOGY
Both primary and secondary research methodologies were used in preparing this study. BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with various analytical, chemical, pharmaceutical and biotechnical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.
INFORMATION SOURCES
Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of chiral products. Data were gathered from various industry sources. BCC spoke with officials and physicians within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.
ABOUT THE AUTHOR
Shalini S. Dewan holds a master's degree in pharmaceutical chemistry. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC include Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets. The lead consultant for this project was Ms. Ruma Chakravarty, who holds a master's degree in biophysics. She has tremendous experience in market research, quality, process improvement, and lean and six sigma concepts.
TABLE OF CONTENTS
CHAPTER ONE: INTRODUCTION 1
STUDY OBJECTIVES 1
REASONS FOR DOING THIS STUDY 1
INTENDED AUDIENCE 2
SCOPE OF THE STUDY 2
METHODOLOGY 2
INFORMATION SOURCES 2
ABOUT THE AUTHOR 3
RELATED BCC RESEARCH REPORTS 3
BCC ONLINE SERVICES 4
DISCLAIMER 4
CHAPTER TWO: EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY 5
EXECUTIVE SUMMARY (CONTINUED) 6
SUMMARY TABLE GLOBAL CHIRAL TECHNOLOGY MARKET BY
SEGMENT, THROUGH 2016 ($ MILLIONS) 7
SUMMARY FIGURE GLOBAL CHIRAL TECHNOLOGY MARKET BY
SEGMENT, THROUGH 2016 ($ MILLIONS) 7
CHAPTER THREE: OVERVIEW 8
DEFINITIONS 8
GENERAL CHARACTERISTICS OF ISOMERS 9
TYPES OF ISOMERISM 9
FIGURE 1 TYPES OF ISOMERISM 9
STRUCTURAL ISOMERISM 10
Skeletal Isomerism 10
Positional Isomerism 10
Functional Isomerism 10
STEREOISOMERISM 11
Geometric Isomerism 11
FIGURE 2 EXAMPLE 1 OF GEOMETRIC ISOMERISM 11
FIGURE 3 EXAMPLE 2 OF GEOMETRIC ISOMERISM 12
FIGURE 4 EXAMPLE 3 OF GEOMETRIC ISOMERISM 12
Properties of Geometrical Isomers 12
TABLE 1 CIS- VS TRANS-ISOMERS 13
Optical Isomerism 13
Properties of Optical Isomers 14
CHAPTER FOUR: CHIRAL TECHNOLOGY 15
CHIRAL SYNTHESIS 15
METHODS OF CHIRAL SYNTHESIS 15
Chiral Pool Synthesis 15
Asymmetric Induction 16
Chiral Auxiliaries 17
TABLE 2 EVANS-TYPE AUXILIARIES 18
Asymmetric Catalysis 18
Chiral Catalyst 18
Metal Ligand Complexes Derived from Chiral
Ligands 19
Chiral Organocatalysts 20
Biocatalysts 20
Types of Asymmetric Catalytic Oxidation Reactions 21
PRODUCTS FOR CHIRAL SYNTHESIS 22
Chiral Intermediates 22
Chiral Amino Acids 23
Chiral Epoxides and Glycidols 24
Saturated Chiral Propionic Acids 24
TABLE 3 CHIRAL INTERMEDIATES FOR VARIOUS INHIBITORS 25
TABLE 4 CHIRAL INTERMEDIATES FOR PHARMACEUTICAL
PRODUCTS 25
TABLE 4 (CONTINUED) 26
TABLE 4 (CONTINUED) 27
Chiral Catalysts 27
Chiral Acid Catalysts 28
Biocatalysts or Enzymes 28
Chiral Auxiliaries 29
Chiral Reagents 29
CHIRAL SEPARATION OR RESOLUTION 30
RESOLUTION BY CRYSTALLIZATION 30
CHIRAL RESOLVING AGENTS 31
CHIRAL COLUMN CHROMATOGRAPHY 31
KINETIC RESOLUTION 32
TABLE 5 PRODUCTION OF COMPOUNDS BY ENZYMATIC
RESOLUTION 33
IMPORTANCE OF CHIRALITY 33
ADVANTAGES 33
Advantages (Continued) 34
ENANTIOPURE MEDICATION 35
TABLE 6 RACEMIC AND ENANTIOMER DRUGS 36
CHAPTER FIVE: REGULATORY ASPECTS 37
APPROVALS OF CHIRAL DRUGS 37
TABLE 7 FDA APPROVALS OF NEW AND GENERIC CHIRAL DRUGS,
2009 TO OCT 2011 37
TABLE 7 (CONTINUED) 38
TABLE 7 (CONTINUED) 39
TABLE 8 FDA ANDA (ABBREVIATED NEW DRUG
APPLICATION)/GENERICS APPROVALS FOR CHIRAL DRUGS,
2009 TO OCT 2011 39
TABLE 8 (CONTINUED) 40
TABLE 8 (CONTINUED) 41
TABLE 8 (CONTINUED) 42
TABLE 8 (CONTINUED) 43
TABLE 9 NEW DRUG APPLICATIONS FOR CHIRAL DRUGS 43
TABLE 10 SAFETY ALERTS, 2009 THROUGH OCT 2010 43
TABLE 10 (CONTINUED) 44
TABLE 11 RECALLED CHIRAL DRUGS, 2009 TO OCT 2011 44
TABLE 11 (CONTINUED) 45
REGULATORY DEVELOPMENTS OF CHIRAL PRODUCTS 45
CHAPTER SIX: MARKET LEADERS IN CHIRAL PRODUCTS 46
TABLE 12 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
INTERMEDIATES 46
TABLE 12 (CONTINUED) 47
TABLE 12 (CONTINUED) 48
TABLE 12 (CONTINUED) 49
TABLE 12 (CONTINUED) 50
TABLE 12 (CONTINUED) 51
TABLE 12 (CONTINUED) 52
TABLE 13 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
CHEMICAL CATALYSTS 52
TABLE 13 (CONTINUED) 53
TABLE 13 (CONTINUED) 54
TABLE 14 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
BIOCATALYSTS 54
TABLE 14 (CONTINUED) 55
TABLE 15 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
AUXILIARIES 55
TABLE 15 (CONTINUED) 56
TABLE 16 LEADING MANUFACTURERS/SUPPLIERS OF OTHER
SYNTHETIC MATERIAL 56
TABLE 16 (CONTINUED) 57
TABLE 17 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
STATIONARY PHASES AND COLUMNS 57
TABLE 17 (CONTINUED) 58
TABLE 17 (CONTINUED) 59
TABLE 18 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 59
TABLE 19 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
RESOLVING/DERIVATIZING AND CRYSTALLIZING AGENTS 60
TABLE 19 (CONTINUED) 61
TABLE 20 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL
ANALYTICAL INSTRUMENTS 61
TABLE 20 (CONTINUED) 62
TABLE 20 (CONTINUED) 63
TABLE 20 (CONTINUED) 64
CHAPTER SEVEN: NEW DEVELOPMENTS 65
TABLE 21 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,
SEPARATION AND ANALYSIS, 2011 65
TABLE 21 (CONTINUED) 66
TABLE 21 (CONTINUED) 67
TABLE 22 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,
SEPARATION AND ANALYSIS, 2010 68
TABLE 22 (CONTINUED) 69
TABLE 22 (CONTINUED) 70
TABLE 22 (CONTINUED) 71
TABLE 22 (CONTINUED) 72
TABLE 23 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,
SEPARATION AND ANALYSIS, 2009 72
TABLE 23 (CONTINUED) 73
TABLE 23 (CONTINUED) 74
TABLE 23 (CONTINUED) 75
TABLE 23 (CONTINUED) 76
TABLE 23 (CONTINUED) 77
CHAPTER EIGHT: GLOBAL MARKET ANALYSIS 78
CHIRAL SYNTHESIS MARKET 78
CHIRAL INTERMEDIATES 79
Market Overview 79
Market Revenues 80
TABLE 24 GLOBAL MARKET FOR CHIRAL INTERMEDIATES BY
REGION, THROUGH 2016 ($ MILLIONS) 81
FIGURE 5 GLOBAL MARKET FOR CHIRAL INTERMEDIATES BY
REGION, 2009-2016 ($ MILLIONS) 81
CHIRAL CHEMICAL CATALYSTS 82
Market Overview 82
Market Revenues 83
TABLE 25 GLOBAL MARKET FOR CHIRAL CHEMICAL CATALYSTS
BY REGION, THROUGH 2016 ($ MILLIONS) 84
FIGURE 6 GLOBAL MARKET FOR CHIRAL CHEMICAL CATALYSTS
BY REGION, 2009-2016 ($ MILLIONS) 84
CHIRAL BIOCATALYST 85
Market Overview 85
Market Overview (Continued) 86
Market Revenues 87
TABLE 26 GLOBAL MARKET FOR CHIRAL BIOCATALYSTS BY
REGION, THROUGH 2016 ($ MILLIONS) 87
FIGURE 7 GLOBAL MARKET FOR CHIRAL BIOCATALYSTS BY
REGION, 2009-2016 ($ MILLIONS) 88
CHIRAL AUXILIARIES 88
Market Overview 89
Market Revenues 89
TABLE 27 GLOBAL MARKET FOR CHIRAL AUXILIARIES BY
REGION, THROUGH 2016 ($ MILLIONS) 90
FIGURE 8 GLOBAL MARKET FOR CHIRAL AUXILIARIES BY
REGION, 2009-2016 ($ MILLIONS) 90
OTHER SYNTHETIC CHIRAL MATERIALS 91
Market Overview 92
Market Revenues 93
TABLE 28 GLOBAL MARKET FOR OTHER SYNTHETIC CHIRAL
MATERIALS BY REGION, THROUGH 2016 ($ MILLIONS) 93
FIGURE 9 GLOBAL MARKET FOR OTHER SYNTHETIC CHIRAL
MATERIALS BY REGION, 2009-2016 ($ MILLIONS) 94
MARKET SHARES OF CHIRAL SYNTHESIS MARKET 94
TABLE 29 GLOBAL CHIRAL SYNTHESIS MARKET SHARES BY
REGION, 2010 (%) 94
FIGURE 10 GLOBAL CHIRAL SYNTHESIS MARKET SHARES BY
REGION, 2010 (%) 95
CHIRAL SEPARATION MARKET 95
CRYSTALLIZING AGENTS 96
Market Overview 97
Market Revenues 98
TABLE 30 GLOBAL MARKET FOR CRYSTALLIZING AGENTS BY
REGION, THROUGH 2016 ($ MILLIONS) 99
FIGURE 11 GLOBAL MARKET FOR CRYSTALLIZING AGENTS BY
REGION, 2009-2016 ($ MILLIONS) 99
CHROMATOGRAPHY COLUMNS AND REAGENTS 100
Market Overview 100
Market Revenues 101
TABLE 31 GLOBAL MARKET FOR CHROMATOGRAPHY COLUMNS
AND REAGENTS BY REGION, THROUGH 2016 ($ MILLIONS) 102
FIGURE 12 GLOBAL MARKET FOR CHROMATOGRAPHY COLUMNS
AND REAGENTS BY REGION, 2009-2016 ($ MILLIONS) 102
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 102
Market Overview 103
Market Revenues 104
TABLE 32 GLOBAL MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS BY REGION, THROUGH 2016 ($
MILLIONS) 104
FIGURE 13 GLOBAL MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS BY REGION, 2009-2016 ($
MILLIONS) 105
ENZYMES IN KINETIC RESOLUTION 105
Market Overview 106
Market Overview (Continued) 107
Market Revenues 107
TABLE 33 GLOBAL MARKET FOR ENZYMES USED IN KINETIC
RESOLUTION BY REGION, THROUGH 2016 ($ MILLIONS) 108
FIGURE 14 GLOBAL MARKET FOR ENZYMES USED IN KINETIC
RESOLUTION BY REGION, 2009-2016 ($ MILLIONS) 108
MARKET SHARES OF CHIRAL SEPARATION MARKET 109
TABLE 34 GLOBAL CHIRAL SEPARATION MARKET SHARES BY
REGION, 2010 (%) 109
FIGURE 15 GLOBAL CHIRAL SEPARATION MARKET SHARES BY
REGION, 2010 (%) 109
CHIRAL ANALYSIS MARKET 110
CHIRAL LIQUID CHROMATOGRAPHY 110
Market Overview 111
Market Revenues 112
TABLE 35 GLOBAL MARKET FOR CHIRAL LIQUID
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 112
FIGURE 16 GLOBAL MARKET FOR CHIRAL LIQUID
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 113
CHIRAL GAS CHROMATOGRAPHY 113
Market Overview 114
Market Revenues 115
TABLE 36 GLOBAL MARKET FOR CHIRAL GAS
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 115
FIGURE 17 GLOBAL MARKET FOR CHIRAL GAS
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 116
CHIRAL CAPILLARY ELECTROPHORESIS 116
Market Overview 117
Market Revenues 118
TABLE 37 GLOBAL MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, THROUGH 2016 ($ MILLIONS) 118
FIGURE 18 GLOBAL MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, 2009-2016 ($ MILLIONS) 119
CHIRAL SUPERCRITICAL FLUID CHROMATOGRAPHY 119
Market Overview 120
Market Revenues 120
TABLE 38 GLOBAL MARKET FOR CHIRAL SUPERCRITICAL FLUID
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 121
FIGURE 19 GLOBAL MARKET FOR CHIRAL SUPERCRITICAL
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 121
CHIRAL POLARIMETERS 122
Market Overview 122
Market Revenues 123
TABLE 39 GLOBAL MARKET FOR CHIRAL POLARIMETERS,
THROUGH 2016 ($ MILLIONS) 123
FIGURE 20 GLOBAL MARKET FOR CHIRAL POLARIMETERS, 2009-
2016 ($ MILLIONS) 124
NMR SHIFT REAGENTS 124
Market Overview 125
Market Revenues 126
TABLE 40 GLOBAL MARKET FOR NMR SHIFT REAGENTS,
THROUGH 2016 ($ MILLIONS) 126
FIGURE 21 GLOBAL MARKET FOR NMR SHIFT REAGENTS, 2009-
2016 ($ MILLIONS) 127
OTHERS 127
Market Overview 128
Market Revenues 128
TABLE 41 GLOBAL MARKET FOR OTHER CHIRAL ANALYSIS
TECHNIQUES, THROUGH 2016 ($ MILLIONS) 129
FIGURE 22 GLOBAL MARKET FOR OTHER CHIRAL ANALYSIS
TECHNIQUES, 2009-2016 ($ MILLIONS) 129
MARKET SHARES OF THE CHIRAL ANALYSIS MARKET 129
TABLE 42 GLOBAL MARKET SHARES OF CHIRAL ANALYSIS
TECHNIQUES BY REGION, 2010 (%) 130
FIGURE 23 GLOBAL MARKET SHARES OF CHIRAL ANALYSIS
TECHNIQUES BY REGION, 2010 (%) 130
CHAPTER NINE: U S MARKET ANALYSIS 131
U S MARKET FOR CHIRAL TECHNOLOGIES 131
TABLE 43 U S MARKET FOR CHIRAL TECHNOLOGIES BY
SEGMENT, THROUGH 2016 ($ MILLIONS) 131
FIGURE 24 U S MARKET FOR CHIRAL TECHNOLOGIES BY
SEGMENT, 2009-2016 ($ MILLIONS) 132
CHIRAL SYNTHESIS MARKET 132
Market Revenues 133
TABLE 44 U S MARKET FOR CHIRAL SYNTHESIS, THROUGH 2016
($ MILLIONS) 133
FIGURE 25 U S MARKET FOR CHIRAL SYNTHESIS, 2009-2016 ($
MILLIONS) 134
Chiral Intermediates 134
Market Overview 135
Market Revenue 135
TABLE 45 U S MARKET FOR CHIRAL INTERMEDIATES, THROUGH
2016 ($ MILLIONS) 136
FIGURE 26 U S MARKET FOR CHIRAL INTERMEDIATES, 2009-2016
($ MILLIONS) 136
Chiral Chemical Catalysts 136
Market Overview 137
Market Revenue 138
TABLE 46 U S MARKET FOR CHIRAL CHEMICAL CATALYSTS,
THROUGH 2016 ($ MILLIONS) 138
FIGURE 27 U S MARKET FOR CHIRAL CHEMICAL CATALYSTS,
2009-2016 ($ MILLIONS) 138
Chiral Biocatalysts 139
Market Overview 139
Market Revenue 140
TABLE 47 U S MARKET FOR CHIRAL BIOCATALYSTS, THROUGH
2016 ($ MILLIONS) 141
FIGURE 28 U S MARKET FOR CHIRAL BIOCATALYSTS, 2009-2016 ($
MILLIONS) 141
Chiral Auxiliaries 141
Market Overview 142
Market Revenue 142
TABLE 48 U S MARKET FOR CHIRAL AUXILIARIES, THROUGH 2016
($ MILLIONS) 143
FIGURE 29 U S MARKET FOR CHIRAL AUXILIARIES, 2009-2016 ($
MILLIONS) 143
Other Synthetic Materials 143
Market Overview 144
Market Revenue 145
TABLE 49 U S MARKET FOR OTHER SYNTHETIC MATERIALS
USED IN CHIRAL SYNTHESIS, THROUGH 2016 ($ MILLIONS) 145
FIGURE 30 U S MARKET FOR OTHER SYNTHETIC MATERIALS
USED IN CHIRAL SYNTHESIS, 2009-2016 ($ MILLIONS) 145
CHIRAL SEPARATION MARKET 146
Market Revenues 146
TABLE 50 U S MARKET FOR CHIRAL SEPARATION, THROUGH 2016
($ MILLIONS) 146
FIGURE 31 U S MARKET FOR CHIRAL SEPARATION, 2009-2016 ($
MILLIONS) 147
Crystallizing Agents 147
TABLE 51 OPTICALLY ACTIVE PHARMACEUTICALS PRODUCTS,
BY CRYSTALLIZATION 148
Market Overview 148
Market Revenue 149
TABLE 52 U S MARKET FOR CRYSTALLIZING AGENTS, THROUGH
2016 ($ MILLIONS) 149
FIGURE 32 U S MARKET FOR CRYSTALLIZING AGENTS, 2009-2016
($ MILLIONS) 150
Chromatography Columns and Reagents 150
Market Overview 151
TABLE 53 U S MARKET FOR CHROMATOGRAPHY COLUMNS AND
REAGENTS, THROUGH 2016 ($ MILLIONS) 152
FIGURE 33 U S MARKET FOR CHROMATOGRAPHY COLUMNS AND
REAGENTS, 2009-2016 ($ MILLIONS) 152
Solvent Extraction Reagents and Instruments 153
Market Overview 153
Market Revenue 154
TABLE 54 U S MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS, THROUGH 2016 ($ MILLIONS) 154
FIGURE 34 U S MARKET FOR SOLVENT EXTRACTION
INSTRUMENTS AND REAGENTS, 2009-2016 ($ MILLIONS) 154
Enzymes in Kinetic Resolution 155
Market Overview 155
Market Revenue 156
TABLE 55 U S MARKET FOR KINETIC RESOLUTION, THROUGH
2016 ($ MILLIONS) 156
FIGURE 35 U S MARKET FOR KINETIC RESOLUTION, THROUGH
2016 ($ MILLIONS) 157
CHIRAL ANALYSIS MARKET 157
Market Revenues 158
TABLE 56 U S MARKET FOR CHIRAL ANALYSIS BY TECHNOLOGY
TYPE, THROUGH 2016 ($ MILLIONS) 158
FIGURE 36 U S MARKET FOR CHIRAL ANALYSIS BY TECHNOLOGY
TYPE, 2009-2016 ($ MILLIONS) 159
Chiral Liquid Chromatography 159
Market Overview 160
Market Revenue 161
TABLE 57 U S MARKET FOR CHIRAL LIQUID CHROMATOGRAPHY,
THROUGH 2016 ($ MILLIONS) 161
FIGURE 37 U S MARKET FOR CHIRAL LIQUID
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 161
Chiral Gas Chromatography 162
Market Overview 162
Market Revenue 163
TABLE 58 U S MARKET FOR GAS CHROMATOGRAPHY, THROUGH
2016 ($ MILLIONS) 163
FIGURE 38 U S MARKET FOR GAS CHROMATOGRAPHY, THROUGH
2016 ($ MILLIONS) 164
Chiral Capillary Electrophoresis 164
Market Overview 165
Market Revenue 166
TABLE 59 U S MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, THROUGH 2016 ($ MILLIONS) 166
FIGURE 39 U S MARKET FOR CHIRAL CAPILLARY
ELECTROPHORESIS, 2009-2016 ($ MILLIONS) 166
Chiral Supercritical Fluid Chromatography 167
Market Overview 167
Market Revenue 168
TABLE 60 U S MARKET FOR CHIRAL SUPERCRITICAL FLUID
CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 168
FIGURE 40 U S MARKET FOR CHIRAL SUPERCRITICAL FLUID
CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 168
CHIRAL POLARIMETERS 169
Market Overview 169
Market Revenue 170
TABLE 61 U S MARKET FOR CHIRAL POLARIMETER, THROUGH
2016 ($ MILLIONS) 170
FIGURE 41 U S MARKET FOR CHIRAL POLARIMETER, 2009-2016 ($
MILLIONS) 171
NMR Shift Reagents 171
TABLE 62 SELECTED CHIRAL DERIVATIZING REAGENTS/NMR
SHIFT REAGENTS FOR 1H AND 19F NMR ANALYSIS 172
Market Overview 172
Market Revenue 173
TABLE 63 U S MARKET FOR NMR SHIFT REAGENTS, THROUGH
2016 ($ MILLIONS) 173
FIGURE 42 U S MARKET FOR NMR SHIFT REAGENTS, 2009-2016 ($
MILLIONS) 173
Others 174
Market Overview 174
Market Revenue 174
TABLE 64 U S MARKET FOR OTHER CHIRAL ANALYSIS, THROUGH
2016 ($ MILLIONS) 175
FIGURE 43 U S MARKET FOR OTHER CHIRAL ANALYSIS, 2009-2016
($ MILLIONS) 175
INDUSTRY LEADER MARKET SHARES 175
CHIRAL INTERMEDIATES 175
TABLE 65 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL INTERMEDIATES IN THE U S , 2010 (%) 176
FIGURE 44 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL INTERMEDIATES IN THE U S , 2010 (%) 177
CHIRAL CHEMICAL CATALYSTS 177
TABLE 66 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL CHEMICAL CATALYSTS IN THE U S , 2010 (%) 178
FIGURE 45 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL CHEMICAL CATALYSTS IN THE U S , 2010 (%) 178
CHIRAL BIOCATALYSTS 179
TABLE 67 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL BIOCATALYSTS IN THE U S , 2010 (%) 179
FIGURE 46 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL BIOCATALYSTS IN THE U S , 2010 (%) 180
CHIRAL AUXILIARIES 180
TABLE 68 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL AUXILIARIES IN THE U S , 2010 (%) 181
FIGURE 47 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL AUXILIARIES IN THE U S , 2010 (%) 181
OTHER SYNTHETIC MATERIALS 182
TABLE 69 MANUFACTURER/SUPPLIER MARKET SHARES OF
OTHER SYNTHETIC MATERIALS IN THE U S , 2010 (%) 182
FIGURE 48 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL SYNTHETIC MATERIALS IN THE U S , 2010 (%) 182
CHIRAL COLUMNS AND STATIONARY PHASES 183
TABLE 70 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL COLUMNS AND STATIONARY PHASES IN THE U S , 2010
(%) 183
FIGURE 49 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL COLUMNS AND STATIONARY PHASES IN THE U S , 2010
(%) 184
CHIRAL RESOLVING/CRYSTALLIZING AGENTS 184
TABLE 71 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL RESOLVING/CRYSTALLIZING AGENTS IN THE U S , 2010
(%) 185
FIGURE 50 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL RESOLVING/CRYSTALLIZING AGENTS IN THE U S , 2010
(%) 185
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 185
TABLE 72 MANUFACTURER/SUPPLIER MARKET SHARES OF
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN THE
U S , 2010 (%) 186
FIGURE 51 MANUFACTURER/SUPPLIER MARKET SHARES OF
SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN THE
U S , 2010 (%) 186
FIGURE 51 (CONTINUED) 187
CHIRAL ANALYSIS INSTRUMENTS 187
TABLE 73 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL ANALYSIS INSTRUMENTS IN THE U S , 2010 (%) 187
TABLE 73 (CONTINUED) 188
FIGURE 52 MANUFACTURER/SUPPLIER MARKET SHARES OF
CHIRAL ANALYSIS INSTRUMENTS IN THE U S , 2010 (%) 188
CHAPTER TEN: MARKET BY INDUSTRY APPLICATION 189
INTRODUCTION 189
CHIRAL TECHNOLOGY MARKET BY INDUSTRY 189
TABLE 74 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
SALES BY INDUSTRY, 2010 (%) 190
FIGURE 53 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
SALES BY INDUSTRY, 2010 (%) 190
PHARMACEUTICALS 190
Pharmaceuticals (Continued) 191
TABLE 75 CHIRAL DRUGS FROM THERAPEUTIC CLASSES 192
TABLE 76 ENANTIOPURE DRUGS 192
TABLE 76 (CONTINUED) 193
TABLE 76 (CONTINUED) 194
Market Revenue 194
TABLE 77 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE PHARMACEUTICAL INDUSTRY BY PRODUCT
TYPE, THROUGH 2016 ($ MILLIONS) 194
FIGURE 54 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE PHARMACEUTICAL INDUSTRY BY PRODUCT
TYPE, 2009-2016 ($ MILLIONS) 195
Market Share 195
TABLE 78 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED BY THE PHARMACEUTICAL
INDUSTRY, 2010 (%) 196
FIGURE 55 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
IN THE PHARMACEUTICAL INDUSTRY BY PRODUCT TYPE, 2010
(%) 196
TABLE 79 U S SALES OF TOP 10 CHIRAL DRUGS, 2010 ($
MILLIONS) 197
BIOCHEMICALS 197
Amino Acids 198
Hydroxy Acids 198
Oligonucleotides 198
Peptides 199
Oligosaccharides 199
Vitamins 200
Market Revenues 200
TABLE 80 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE BIOCHEMICAL INDUSTRY, THROUGH 2016
($ MILLIONS) 200
FIGURE 56 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS TO THE BIOCHEMICAL INDUSTRY, 2009-2016 ($
MILLIONS) 201
Market Share 201
TABLE 81 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE BIOCHEMICAL INDUSTRY,
2010 (%) 202
FIGURE 57 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE BIOCHEMICAL INDUSTRY,
2010 (%) 202
PESTICIDES/AGROCHEMICAL INDUSTRY 202
Pesticides/Agrochemical … (Continued) 203
TABLE 82 CHIRAL PESTICIDES 204
Pesticides/Agrochemical … (Continued) 205
Market Revenues 206
TABLE 83 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN THE AGROCHEMICAL INDUSTRY, THROUGH 2016
($ MILLIONS) 206
FIGURE 58 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN AGROCHEMICAL INDUSTRY, THROUGH 2016 ($
MILLIONS) 207
Market Share 207
TABLE 84 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE AGROCHEMICAL
INDUSTRY, 2010 (%) 207
FIGURE 59 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN THE AGROCHEMICAL
INDUSTRY, 2010 (%) 208
OTHER INDUSTRIES 208
Aromas and Fragrances 208
Aromas and Fragrances (Continued) 209
TABLE 85 CHIRAL AROMA COMPOUNDS 210
Liquid Crystals 210
Liquid Crystals (Continued) 211
Polymers 212
Market Revenues 213
TABLE 86 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN OTHER INDUSTRIES, THROUGH 2016 ($
MILLIONS) 213
FIGURE 60 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING
PRODUCTS IN OTHER INDUSTRIES, THROUGH 2016 ($
MILLIONS) 214
Market Share 214
TABLE 87 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN OTHER INDUSTRIES, 2010 (%) 215
FIGURE 61 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY
ENABLING PRODUCTS USED IN OTHER INDUSTRIES, 2010 (%) 215
CHAPTER ELEVEN: PATENT ANALYSIS 216
PATENTS BY YEAR 216
TABLE 88 U S PATENTS FOR CHIRAL PRODUCTS BY YEAR, 2009
TO OCT 2011 (NO ) 217
PATENTS BY TECHNOLOGY 217
TABLE 89 U S PATENTS FOR CHIRAL PRODUCTS BY
TECHNOLOGY, 2009 TO OCT 2011 (NO ) 218
FIGURE 62 U S PATENTS FOR CHIRAL PRODUCTS BY
TECHNOLOGY, 2009 TO OCT 2011 (NO ) 218
PATENTS BY TYPE 218
TABLE 90 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE, 2009
TO OCT 2011 (NO ) 219
FIGURE 63 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE, 2009
TO OCT 2011 (NO ) 219
TABLE 91 U S PATENTS FOR CHIRAL RESOLUTION BY TYPE, 2009
TO OCT 2011 (NO ) 220
FIGURE 64 U S PATENTS FOR CHIRAL RESOLUTION BY TYPE,
2009 TO OCT 2011 (NO ) 220
TABLE 92 U S PATENTS FOR CHIRAL ANALYSIS, 2009 TO OCT 2011
(NO ) 221
FIGURE 65 U S PATENTS BY TYPE FOR CHIRAL ANALYSIS, 2009
TO OCT 2011 (NO ) 221
PATENTS BY COMPANY 222
TABLE 93 U S PATENTS FOR CHIRAL SYNTHESIS BY COMPANY,
2009 TO OCT 2011 (NO ) 222
TABLE 93 (CONTINUED) 223
TABLE 94 U S PATENTS FOR CHIRAL RESOLUTION BY COMPANY,
2009 TO OCT 2011 (NO ) 224
TABLE 95 U S PATENTS FOR CHIRAL ANALYSIS BY COMPANY,
2009 TO OCT 2011 (NO ) 225
PATENTS BY COUNTRY 225
TABLE 96 U S PATENTS FOR CHIRAL SYNTHESIS BY COUNTRY,
2009 TO OCT 2011 (NO ) 225
TABLE 96 (CONTINUED) 226
TABLE 97 SHARES OF U S CHIRAL SYNTHESIS PATENTS BY
COUNTRY, 2009 TO OCT 2011 (%) 226
TABLE 97 (CONTINUED) 227
TABLE 98 U S PATENTS FOR CHIRAL RESOLUTION/SEPARATION
BY COUNTRY, 2009 TO OCT 2011 (NO ) 227
TABLE 99 SHARES OF U S CHIRAL RESOLUTION/SEPARATION
PATENTS BY COUNTRY, 2009 TO OCT 2011 (%) 228
TABLE 100 U S PATENTS FOR CHIRAL ANALYSIS BY COUNTRY,
2009 TO OCT 2011 (NO ) 228
TABLE 101 SHARES OF U S CHIRAL ANALYSIS PATENTS BY
COUNTRY, 2009 TO OCT 2011 (%) 229
PATENTS BY ASSIGNEE 229
TABLE 102 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE OF
ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 229
TABLE 103 U S PATENTS FOR CHIRAL RESOLUTION/SEPARATION
BY TYPE OF ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 230
TABLE 104 U S PATENTS FOR CHIRAL ANALYSIS BY TYPE OF
ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 230
CHAPTER TWELVE: CURRENT CHIRAL MARKET ENVIRONMENT 231
INTRODUCTION 231
MARKET TRENDS IN THE ASYMMETRIC SYNTHESIS MARKET 232
MARKET TRENDS IN THE ASYMMETRIC SYNTHESIS MARKET 233
MARKET TRENDS IN CHIRAL RESOLUTION 234
MARKET TRENDS IN CHIRAL ANALYSIS 235
MARKET TRENDS IN CHIRAL … (CONTINUED) 236
MARKET TRENDS IN CHIRAL … (CONTINUED) 237
CHAPTER THIRTEEN: COMPANY PROFILES 238
3B SCIENTIFIC CORP 238
ABA CHEMICALS CORP 238
AESICA PHARMACEUTICALS LTD 239
AGILENT TECHNOLOGIES 239
ALLIED INDUSTRIAL CORP LTD 240
ALMAC GROUP LTD 240
AMPAC FINE CHEMICALS LLC 241
ARCH PHARMALABS LTD 241
ARRAN CHEMICAL CO LTD 242
AVANTIUM TECHNOLOGIES BV 243
AVANTOR PERFORMANCE MATERIALS 243
BACHEM AMERICAS 244
BASF SE 245
BAYER AG 245
BECKMAN COULTER INC 246
BIOCATALYSTS LTD 247
BOULDER SCIENTIFIC CO 247
BRUKER AXS GMBH 248
CAMBREX CORP 249
CARBOSYNTH LTD 250
CHEMTURA CORP 250
CHIRAL BIOSCIENCES LTD 251
CHIRAL MANAGEMENT 251
CHIRAL TECHNOLOGIES INC 252
CHIRAL TECHNOLOGIES EUROPE 252
CHIRALVISION BV 253
CHIROTECH TECHNOLOGY LTD 253
CHONGQING CHIRAL BIOCATALYSIS TECHNOLOGY CO LTD 254
CHROMACOL LTD 254
CHROMTECH GESELLSCHAFT FÜR ANALYTISCHE
MEßTECHNIK MBH 255
CODEXIS INC 255
CORDEN PHARMA SWITZERLAND LLC 256
CYTEC INDUSTRIES INC 257
DAICEL CORP 258
DAINIPPON SUMITOMO PHARMA CO LTD 258
DIONEX CORP 259
DOW CHEMICAL CO 260
DOW PHARMACEUTICAL SCIENCES 260
DSM PHARMACEUTICAL PRODUCTS 261
ENZYTECH CO LTD 262
EVOCATAL GMBH 262
FARBEN-CHEM EUROPE LTD 263
GENENCOR INTERNATIONAL INC 263
GILSON INC 264
JASCO INC 264
JOHNSON MATTHEY PLC 265
KANEKA CORP 266
KEMFINE LTD 267
KOCH MODULAR PROCESS SYSTEMS 267
LANXESS AG 268
LASERCHROM HPLC LABORATORIES LTD 269
LG CHEM EUROPE GMBH 269
LONZA 270
LOUSTON INTERNATIONAL INC 270
MACHEREY-NAGEL GMBH & CO KG 271
MARRESEARCH GMBH 271
MEGA S N C 272
MERCK KGAA 272
NOVASEP 273
NOVOZYMES A/S 274
OUTOTEC OYJ 274
PANALYTICAL INC 275
PDR-CHIRAL LLC 276
PERKINELMER 276
PHENOMENEX INC 277
PROZOMIX LTD 278
RARE EARTH PRODUCTS INC 278
REGIS TECHNOLOGIES INC 279
RHODIA INC USA 279
ROCHE APPLIED SCIENCE 280
ROUSSELET CENTRIFUGATION SA 281
RUDOLPH INSTRUMENTS 281
SHIMADZU CORP 282
SIGMA-ALDRICH 282
SILICYCLE 283
STREM CHEMICALS INC 284
SUPELCO INC 285
SYNQUEST LABORATORIES INC 285
SYNTHETECH INC 286
SYMRISE AG 286
TAKEDA PHARMACEUTICAL CO LTD 287
TCI AMERICA 288
TAKASAGO INTERNATIONAL CORP 289
THERMO FISHER SCIENTIFIC 289
VERENIUM CORP 290
WUXI APPTEC CO LTD 291
YAMAKAWA CHEMICAL 292
YMC AMERICA INC 292
ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD 293
ZIRCHROM SEPARATIONS INC 293
APPENDIX: ABBREVIATIONS 294
ABBREVIATIONS 294
ABBREVIATIONS (CONTINUED) 295
ABBREVIATIONS (CONTINUED) 296
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