Global Markets for Chiral Technology -- Focus on the U.S.

NEW YORK, May 31, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global Markets for Chiral Technology -- Focus on the U.S.

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INTRODUCTION

STUDY OBJECTIVES

BCC's goal in conducting this study is to provide an overview of the current and future global market for chiral products and technologies used in today's world. The key objective is to present a comprehensive analysis of the current market and its future direction in the chiral market as an important tool in various therapeutic industries and other industries.

This report explores present and future strategies within the chiral market, including the synthesis, separation and analysis of chiral products. The improvisation of the market, the setbacks and the needs of the market are discussed in this report. An overview of chirality, and the chiral products and technologies used in the past and currently are discussed in this report.

A detailed analysis of the structure of the chiral industry has been conducted. This includes chiral synthesis, chiral separation/resolution and chiral analysis. Revenues are broken down by global region from 2009 to 2011 and estimated for the five-year period from 2011 through 2016.

Applications for chiral products and technologies are also discussed in this report, with an emphasis on the usage in the pharmaceutical, biochemical and agrochemical industries. The report also covers significant patents and their allotment in each category.

REASONS FOR DOING THIS STUDY

This study was conducted to provide an update of new developments in the chiral technology market. The current study covers the global market for chiral products, with a specific focus on the U.S. markets, European markets and emerging markets. This study was conducted to provide a detailed market analysis of chiral-enabling products, including the factors influencing this market. New advancements and the need for enantiopure compounds have driven growth within this market. This study looks at most of the systems influenced by these factors.

Acquisition strategies and collaborations by companies are also covered in this report. This study also discusses the strength and weaknesses of each system/technology in light of the new technologies, growing competition and changing customer needs.

INTENDED AUDIENCE

This study contributes to the areas of market growth in therapeutic segments through chiral products and technologies from the point of view of manufacturers and users. The pharmaceutical and biopharmaceutical industries, agrochemical industries, physicians, hospitals and research institutes will find this study to be of interest.

SCOPE OF THE STUDY

The scope of this study encompasses the chiral markets with their usage in the pharmaceutical, biotechnical and agrochemical markets. BCC analyzes each market and its applications by its need for chiral products, their regulatory environment, technology involved, market projections and market share. Technological issues include the latest trends and developments.

METHODOLOGY

Both primary and secondary research methodologies were used in preparing this study. BCC conducted a comprehensive literature search, which included technical newsletters and journals, and many other sources. Data were collected through interviews and correspondence with various analytical, chemical, pharmaceutical and biotechnical experts. Projections were based on estimates such as the current number of end users, potential end users, mergers and acquisitions, and market trends.

INFORMATION SOURCES

Many companies within the industry were surveyed to obtain data for this study. Included were manufacturers and end users of chiral products. Data were gathered from various industry sources. BCC spoke with officials and physicians within the industry, consulted newsletters, company literature, product literature and a host of technical articles, journals, indexes and abstracts. Exhaustive investigations of databases by key terminology were completed. In addition, data were compiled from current financial, trade and government sources.

ABOUT THE AUTHOR

Shalini S. Dewan holds a master's degree in pharmaceutical chemistry. Among the research topics she has covered are studies on compounds of potential pharmaceutical interest from ibuprofen and 2-naphthyl acetic acid. Shalini was awarded a Gold Medal by the Prime Minister of India for her work and has worked with top companies in India and in the U.S. Some of her other reports with BCC include Reagents for Chromatography; Spectroscopy, An Enduring Market; Advanced Drug Delivery Systems: Technologies and Global Markets; Orthopedic Drugs, Implants and Devices; Medical Imaging Reagents and Analysis Equipment; Pharmaceutical Regulatory Industry; The Dynamic Media, Sera and Reagent Market in Biotechnology; Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets; Chiral Technology: Global Markets; Autacoids and Related Drugs: Technologies and Global Markets; Contraceptives: Technologies and Global Markets; Liver Disease Treatments: The Global Market; Hormone Replacement Therapies and Other Hormone Therapies: Global Markets; Cardiovascular Medicine: Diagnostics, Drugs and Devices; and Cancer Therapies: Technologies and Global Markets. The lead consultant for this project was Ms. Ruma Chakravarty , who holds a master's degree in biophysics. She has tremendous experience in market research, quality, process improvement, and lean and six sigma concepts.

TABLE OF CONTENTS

CHAPTER ONE: INTRODUCTION 1

STUDY OBJECTIVES 1

REASONS FOR DOING THIS STUDY 1

INTENDED AUDIENCE 2

SCOPE OF THE STUDY 2

METHODOLOGY 2

INFORMATION SOURCES 2

ABOUT THE AUTHOR 3

RELATED BCC RESEARCH REPORTS 3

BCC ONLINE SERVICES 4

DISCLAIMER 4

CHAPTER TWO: EXECUTIVE SUMMARY 5

EXECUTIVE SUMMARY 5

EXECUTIVE SUMMARY (CONTINUED) 6

SUMMARY TABLE GLOBAL CHIRAL TECHNOLOGY MARKET BY

SEGMENT, THROUGH 2016 ($ MILLIONS) 7

SUMMARY FIGURE GLOBAL CHIRAL TECHNOLOGY MARKET BY

SEGMENT, THROUGH 2016 ($ MILLIONS) 7

CHAPTER THREE: OVERVIEW 8

DEFINITIONS 8

GENERAL CHARACTERISTICS OF ISOMERS 9

TYPES OF ISOMERISM 9

FIGURE 1 TYPES OF ISOMERISM 9

STRUCTURAL ISOMERISM 10

Skeletal Isomerism 10

Positional Isomerism 10

Functional Isomerism 10

STEREOISOMERISM 11

Geometric Isomerism 11

FIGURE 2 EXAMPLE 1 OF GEOMETRIC ISOMERISM 11

FIGURE 3 EXAMPLE 2 OF GEOMETRIC ISOMERISM 12

FIGURE 4 EXAMPLE 3 OF GEOMETRIC ISOMERISM 12

Properties of Geometrical Isomers 12

TABLE 1 CIS- VS TRANS-ISOMERS 13

Optical Isomerism 13

Properties of Optical Isomers 14

CHAPTER FOUR: CHIRAL TECHNOLOGY 15

CHIRAL SYNTHESIS 15

METHODS OF CHIRAL SYNTHESIS 15

Chiral Pool Synthesis 15

Asymmetric Induction 16

Chiral Auxiliaries 17

TABLE 2 EVANS-TYPE AUXILIARIES 18

Asymmetric Catalysis 18

Chiral Catalyst 18

Metal Ligand Complexes Derived from Chiral

Ligands 19

Chiral Organocatalysts 20

Biocatalysts 20

Types of Asymmetric Catalytic Oxidation Reactions 21

PRODUCTS FOR CHIRAL SYNTHESIS 22

Chiral Intermediates 22

Chiral Amino Acids 23

Chiral Epoxides and Glycidols 24

Saturated Chiral Propionic Acids 24

TABLE 3 CHIRAL INTERMEDIATES FOR VARIOUS INHIBITORS 25

TABLE 4 CHIRAL INTERMEDIATES FOR PHARMACEUTICAL

PRODUCTS 25

TABLE 4 (CONTINUED) 26

TABLE 4 (CONTINUED) 27

Chiral Catalysts 27

Chiral Acid Catalysts 28

Biocatalysts or Enzymes 28

Chiral Auxiliaries 29

Chiral Reagents 29

CHIRAL SEPARATION OR RESOLUTION 30

RESOLUTION BY CRYSTALLIZATION 30

CHIRAL RESOLVING AGENTS 31

CHIRAL COLUMN CHROMATOGRAPHY 31

KINETIC RESOLUTION 32

TABLE 5 PRODUCTION OF COMPOUNDS BY ENZYMATIC

RESOLUTION 33

IMPORTANCE OF CHIRALITY 33

ADVANTAGES 33

Advantages (Continued) 34

ENANTIOPURE MEDICATION 35

TABLE 6 RACEMIC AND ENANTIOMER DRUGS 36

CHAPTER FIVE: REGULATORY ASPECTS 37

APPROVALS OF CHIRAL DRUGS 37

TABLE 7 FDA APPROVALS OF NEW AND GENERIC CHIRAL DRUGS,

2009 TO OCT 2011 37

TABLE 7 (CONTINUED) 38

TABLE 7 (CONTINUED) 39

TABLE 8 FDA ANDA (ABBREVIATED NEW DRUG

APPLICATION)/GENERICS APPROVALS FOR CHIRAL DRUGS,

2009 TO OCT 2011 39

TABLE 8 (CONTINUED) 40

TABLE 8 (CONTINUED) 41

TABLE 8 (CONTINUED) 42

TABLE 8 (CONTINUED) 43

TABLE 9 NEW DRUG APPLICATIONS FOR CHIRAL DRUGS 43

TABLE 10 SAFETY ALERTS, 2009 THROUGH OCT 2010 43

TABLE 10 (CONTINUED) 44

TABLE 11 RECALLED CHIRAL DRUGS, 2009 TO OCT 2011 44

TABLE 11 (CONTINUED) 45

REGULATORY DEVELOPMENTS OF CHIRAL PRODUCTS 45

CHAPTER SIX: MARKET LEADERS IN CHIRAL PRODUCTS 46

TABLE 12 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

INTERMEDIATES 46

TABLE 12 (CONTINUED) 47

TABLE 12 (CONTINUED) 48

TABLE 12 (CONTINUED) 49

TABLE 12 (CONTINUED) 50

TABLE 12 (CONTINUED) 51

TABLE 12 (CONTINUED) 52

TABLE 13 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

CHEMICAL CATALYSTS 52

TABLE 13 (CONTINUED) 53

TABLE 13 (CONTINUED) 54

TABLE 14 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

BIOCATALYSTS 54

TABLE 14 (CONTINUED) 55

TABLE 15 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

AUXILIARIES 55

TABLE 15 (CONTINUED) 56

TABLE 16 LEADING MANUFACTURERS/SUPPLIERS OF OTHER

SYNTHETIC MATERIAL 56

TABLE 16 (CONTINUED) 57

TABLE 17 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

STATIONARY PHASES AND COLUMNS 57

TABLE 17 (CONTINUED) 58

TABLE 17 (CONTINUED) 59

TABLE 18 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 59

TABLE 19 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

RESOLVING/DERIVATIZING AND CRYSTALLIZING AGENTS 60

TABLE 19 (CONTINUED) 61

TABLE 20 LEADING MANUFACTURERS/SUPPLIERS OF CHIRAL

ANALYTICAL INSTRUMENTS 61

TABLE 20 (CONTINUED) 62

TABLE 20 (CONTINUED) 63

TABLE 20 (CONTINUED) 64

CHAPTER SEVEN: NEW DEVELOPMENTS 65

TABLE 21 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,

SEPARATION AND ANALYSIS, 2011 65

TABLE 21 (CONTINUED) 66

TABLE 21 (CONTINUED) 67

TABLE 22 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,

SEPARATION AND ANALYSIS, 2010 68

TABLE 22 (CONTINUED) 69

TABLE 22 (CONTINUED) 70

TABLE 22 (CONTINUED) 71

TABLE 22 (CONTINUED) 72

TABLE 23 NEW DEVELOPMENTS IN CHIRAL SYNTHESIS,

SEPARATION AND ANALYSIS, 2009 72

TABLE 23 (CONTINUED) 73

TABLE 23 (CONTINUED) 74

TABLE 23 (CONTINUED) 75

TABLE 23 (CONTINUED) 76

TABLE 23 (CONTINUED) 77

CHAPTER EIGHT: GLOBAL MARKET ANALYSIS 78

CHIRAL SYNTHESIS MARKET 78

CHIRAL INTERMEDIATES 79

Market Overview 79

Market Revenues 80

TABLE 24 GLOBAL MARKET FOR CHIRAL INTERMEDIATES BY

REGION, THROUGH 2016 ($ MILLIONS) 81

FIGURE 5 GLOBAL MARKET FOR CHIRAL INTERMEDIATES BY

REGION, 2009-2016 ($ MILLIONS) 81

CHIRAL CHEMICAL CATALYSTS 82

Market Overview 82

Market Revenues 83

TABLE 25 GLOBAL MARKET FOR CHIRAL CHEMICAL CATALYSTS

BY REGION, THROUGH 2016 ($ MILLIONS) 84

FIGURE 6 GLOBAL MARKET FOR CHIRAL CHEMICAL CATALYSTS

BY REGION, 2009-2016 ($ MILLIONS) 84

CHIRAL BIOCATALYST 85

Market Overview 85

Market Overview (Continued) 86

Market Revenues 87

TABLE 26 GLOBAL MARKET FOR CHIRAL BIOCATALYSTS BY

REGION, THROUGH 2016 ($ MILLIONS) 87

FIGURE 7 GLOBAL MARKET FOR CHIRAL BIOCATALYSTS BY

REGION, 2009-2016 ($ MILLIONS) 88

CHIRAL AUXILIARIES 88

Market Overview 89

Market Revenues 89

TABLE 27 GLOBAL MARKET FOR CHIRAL AUXILIARIES BY

REGION, THROUGH 2016 ($ MILLIONS) 90

FIGURE 8 GLOBAL MARKET FOR CHIRAL AUXILIARIES BY

REGION, 2009-2016 ($ MILLIONS) 90

OTHER SYNTHETIC CHIRAL MATERIALS 91

Market Overview 92

Market Revenues 93

TABLE 28 GLOBAL MARKET FOR OTHER SYNTHETIC CHIRAL

MATERIALS BY REGION, THROUGH 2016 ($ MILLIONS) 93

FIGURE 9 GLOBAL MARKET FOR OTHER SYNTHETIC CHIRAL

MATERIALS BY REGION, 2009-2016 ($ MILLIONS) 94

MARKET SHARES OF CHIRAL SYNTHESIS MARKET 94

TABLE 29 GLOBAL CHIRAL SYNTHESIS MARKET SHARES BY

REGION, 2010 (%) 94

FIGURE 10 GLOBAL CHIRAL SYNTHESIS MARKET SHARES BY

REGION, 2010 (%) 95

CHIRAL SEPARATION MARKET 95

CRYSTALLIZING AGENTS 96

Market Overview 97

Market Revenues 98

TABLE 30 GLOBAL MARKET FOR CRYSTALLIZING AGENTS BY

REGION, THROUGH 2016 ($ MILLIONS) 99

FIGURE 11 GLOBAL MARKET FOR CRYSTALLIZING AGENTS BY

REGION, 2009-2016 ($ MILLIONS) 99

CHROMATOGRAPHY COLUMNS AND REAGENTS 100

Market Overview 100

Market Revenues 101

TABLE 31 GLOBAL MARKET FOR CHROMATOGRAPHY COLUMNS

AND REAGENTS BY REGION, THROUGH 2016 ($ MILLIONS) 102

FIGURE 12 GLOBAL MARKET FOR CHROMATOGRAPHY COLUMNS

AND REAGENTS BY REGION, 2009-2016 ($ MILLIONS) 102

SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 102

Market Overview 103

Market Revenues 104

TABLE 32 GLOBAL MARKET FOR SOLVENT EXTRACTION

INSTRUMENTS AND REAGENTS BY REGION, THROUGH 2016 ($

MILLIONS) 104

FIGURE 13 GLOBAL MARKET FOR SOLVENT EXTRACTION

INSTRUMENTS AND REAGENTS BY REGION, 2009-2016 ($

MILLIONS) 105

ENZYMES IN KINETIC RESOLUTION 105

Market Overview 106

Market Overview (Continued) 107

Market Revenues 107

TABLE 33 GLOBAL MARKET FOR ENZYMES USED IN KINETIC

RESOLUTION BY REGION, THROUGH 2016 ($ MILLIONS) 108

FIGURE 14 GLOBAL MARKET FOR ENZYMES USED IN KINETIC

RESOLUTION BY REGION, 2009-2016 ($ MILLIONS) 108

MARKET SHARES OF CHIRAL SEPARATION MARKET 109

TABLE 34 GLOBAL CHIRAL SEPARATION MARKET SHARES BY

REGION, 2010 (%) 109

FIGURE 15 GLOBAL CHIRAL SEPARATION MARKET SHARES BY

REGION, 2010 (%) 109

CHIRAL ANALYSIS MARKET 110

CHIRAL LIQUID CHROMATOGRAPHY 110

Market Overview 111

Market Revenues 112

TABLE 35 GLOBAL MARKET FOR CHIRAL LIQUID

CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 112

FIGURE 16 GLOBAL MARKET FOR CHIRAL LIQUID

CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 113

CHIRAL GAS CHROMATOGRAPHY 113

Market Overview 114

Market Revenues 115

TABLE 36 GLOBAL MARKET FOR CHIRAL GAS

CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 115

FIGURE 17 GLOBAL MARKET FOR CHIRAL GAS

CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 116

CHIRAL CAPILLARY ELECTROPHORESIS 116

Market Overview 117

Market Revenues 118

TABLE 37 GLOBAL MARKET FOR CHIRAL CAPILLARY

ELECTROPHORESIS, THROUGH 2016 ($ MILLIONS) 118

FIGURE 18 GLOBAL MARKET FOR CHIRAL CAPILLARY

ELECTROPHORESIS, 2009-2016 ($ MILLIONS) 119

CHIRAL SUPERCRITICAL FLUID CHROMATOGRAPHY 119

Market Overview 120

Market Revenues 120

TABLE 38 GLOBAL MARKET FOR CHIRAL SUPERCRITICAL FLUID

CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 121

FIGURE 19 GLOBAL MARKET FOR CHIRAL SUPERCRITICAL

CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 121

CHIRAL POLARIMETERS 122

Market Overview 122

Market Revenues 123

TABLE 39 GLOBAL MARKET FOR CHIRAL POLARIMETERS,

THROUGH 2016 ($ MILLIONS) 123

FIGURE 20 GLOBAL MARKET FOR CHIRAL POLARIMETERS, 2009-

2016 ($ MILLIONS) 124

NMR SHIFT REAGENTS 124

Market Overview 125

Market Revenues 126

TABLE 40 GLOBAL MARKET FOR NMR SHIFT REAGENTS,

THROUGH 2016 ($ MILLIONS) 126

FIGURE 21 GLOBAL MARKET FOR NMR SHIFT REAGENTS, 2009-

2016 ($ MILLIONS) 127

OTHERS 127

Market Overview 128

Market Revenues 128

TABLE 41 GLOBAL MARKET FOR OTHER CHIRAL ANALYSIS

TECHNIQUES, THROUGH 2016 ($ MILLIONS) 129

FIGURE 22 GLOBAL MARKET FOR OTHER CHIRAL ANALYSIS

TECHNIQUES, 2009-2016 ($ MILLIONS) 129

MARKET SHARES OF THE CHIRAL ANALYSIS MARKET 129

TABLE 42 GLOBAL MARKET SHARES OF CHIRAL ANALYSIS

TECHNIQUES BY REGION, 2010 (%) 130

FIGURE 23 GLOBAL MARKET SHARES OF CHIRAL ANALYSIS

TECHNIQUES BY REGION, 2010 (%) 130

CHAPTER NINE: U S MARKET ANALYSIS 131

U S MARKET FOR CHIRAL TECHNOLOGIES 131

TABLE 43 U S MARKET FOR CHIRAL TECHNOLOGIES BY

SEGMENT, THROUGH 2016 ($ MILLIONS) 131

FIGURE 24 U S MARKET FOR CHIRAL TECHNOLOGIES BY

SEGMENT, 2009-2016 ($ MILLIONS) 132

CHIRAL SYNTHESIS MARKET 132

Market Revenues 133

TABLE 44 U S MARKET FOR CHIRAL SYNTHESIS, THROUGH 2016

($ MILLIONS) 133

FIGURE 25 U S MARKET FOR CHIRAL SYNTHESIS, 2009-2016 ($

MILLIONS) 134

Chiral Intermediates 134

Market Overview 135

Market Revenue 135

TABLE 45 U S MARKET FOR CHIRAL INTERMEDIATES, THROUGH

2016 ($ MILLIONS) 136

FIGURE 26 U S MARKET FOR CHIRAL INTERMEDIATES, 2009-2016

($ MILLIONS) 136

Chiral Chemical Catalysts 136

Market Overview 137

Market Revenue 138

TABLE 46 U S MARKET FOR CHIRAL CHEMICAL CATALYSTS,

THROUGH 2016 ($ MILLIONS) 138

FIGURE 27 U S MARKET FOR CHIRAL CHEMICAL CATALYSTS,

2009-2016 ($ MILLIONS) 138

Chiral Biocatalysts 139

Market Overview 139

Market Revenue 140

TABLE 47 U S MARKET FOR CHIRAL BIOCATALYSTS, THROUGH

2016 ($ MILLIONS) 141

FIGURE 28 U S MARKET FOR CHIRAL BIOCATALYSTS, 2009-2016 ($

MILLIONS) 141

Chiral Auxiliaries 141

Market Overview 142

Market Revenue 142

TABLE 48 U S MARKET FOR CHIRAL AUXILIARIES, THROUGH 2016

($ MILLIONS) 143

FIGURE 29 U S MARKET FOR CHIRAL AUXILIARIES, 2009-2016 ($

MILLIONS) 143

Other Synthetic Materials 143

Market Overview 144

Market Revenue 145

TABLE 49 U S MARKET FOR OTHER SYNTHETIC MATERIALS

USED IN CHIRAL SYNTHESIS, THROUGH 2016 ($ MILLIONS) 145

FIGURE 30 U S MARKET FOR OTHER SYNTHETIC MATERIALS

USED IN CHIRAL SYNTHESIS, 2009-2016 ($ MILLIONS) 145

CHIRAL SEPARATION MARKET 146

Market Revenues 146

TABLE 50 U S MARKET FOR CHIRAL SEPARATION, THROUGH 2016

($ MILLIONS) 146

FIGURE 31 U S MARKET FOR CHIRAL SEPARATION, 2009-2016 ($

MILLIONS) 147

Crystallizing Agents 147

TABLE 51 OPTICALLY ACTIVE PHARMACEUTICALS PRODUCTS,

BY CRYSTALLIZATION 148

Market Overview 148

Market Revenue 149

TABLE 52 U S MARKET FOR CRYSTALLIZING AGENTS, THROUGH

2016 ($ MILLIONS) 149

FIGURE 32 U S MARKET FOR CRYSTALLIZING AGENTS, 2009-2016

($ MILLIONS) 150

Chromatography Columns and Reagents 150

Market Overview 151

TABLE 53 U S MARKET FOR CHROMATOGRAPHY COLUMNS AND

REAGENTS, THROUGH 2016 ($ MILLIONS) 152

FIGURE 33 U S MARKET FOR CHROMATOGRAPHY COLUMNS AND

REAGENTS, 2009-2016 ($ MILLIONS) 152

Solvent Extraction Reagents and Instruments 153

Market Overview 153

Market Revenue 154

TABLE 54 U S MARKET FOR SOLVENT EXTRACTION

INSTRUMENTS AND REAGENTS, THROUGH 2016 ($ MILLIONS) 154

FIGURE 34 U S MARKET FOR SOLVENT EXTRACTION

INSTRUMENTS AND REAGENTS, 2009-2016 ($ MILLIONS) 154

Enzymes in Kinetic Resolution 155

Market Overview 155

Market Revenue 156

TABLE 55 U S MARKET FOR KINETIC RESOLUTION, THROUGH

2016 ($ MILLIONS) 156

FIGURE 35 U S MARKET FOR KINETIC RESOLUTION, THROUGH

2016 ($ MILLIONS) 157

CHIRAL ANALYSIS MARKET 157

Market Revenues 158

TABLE 56 U S MARKET FOR CHIRAL ANALYSIS BY TECHNOLOGY

TYPE, THROUGH 2016 ($ MILLIONS) 158

FIGURE 36 U S MARKET FOR CHIRAL ANALYSIS BY TECHNOLOGY

TYPE, 2009-2016 ($ MILLIONS) 159

Chiral Liquid Chromatography 159

Market Overview 160

Market Revenue 161

TABLE 57 U S MARKET FOR CHIRAL LIQUID CHROMATOGRAPHY,

THROUGH 2016 ($ MILLIONS) 161

FIGURE 37 U S MARKET FOR CHIRAL LIQUID

CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 161

Chiral Gas Chromatography 162

Market Overview 162

Market Revenue 163

TABLE 58 U S MARKET FOR GAS CHROMATOGRAPHY, THROUGH

2016 ($ MILLIONS) 163

FIGURE 38 U S MARKET FOR GAS CHROMATOGRAPHY, THROUGH

2016 ($ MILLIONS) 164

Chiral Capillary Electrophoresis 164

Market Overview 165

Market Revenue 166

TABLE 59 U S MARKET FOR CHIRAL CAPILLARY

ELECTROPHORESIS, THROUGH 2016 ($ MILLIONS) 166

FIGURE 39 U S MARKET FOR CHIRAL CAPILLARY

ELECTROPHORESIS, 2009-2016 ($ MILLIONS) 166

Chiral Supercritical Fluid Chromatography 167

Market Overview 167

Market Revenue 168

TABLE 60 U S MARKET FOR CHIRAL SUPERCRITICAL FLUID

CHROMATOGRAPHY, THROUGH 2016 ($ MILLIONS) 168

FIGURE 40 U S MARKET FOR CHIRAL SUPERCRITICAL FLUID

CHROMATOGRAPHY, 2009-2016 ($ MILLIONS) 168

CHIRAL POLARIMETERS 169

Market Overview 169

Market Revenue 170

TABLE 61 U S MARKET FOR CHIRAL POLARIMETER, THROUGH

2016 ($ MILLIONS) 170

FIGURE 41 U S MARKET FOR CHIRAL POLARIMETER, 2009-2016 ($

MILLIONS) 171

NMR Shift Reagents 171

TABLE 62 SELECTED CHIRAL DERIVATIZING REAGENTS/NMR

SHIFT REAGENTS FOR 1H AND 19F NMR ANALYSIS 172

Market Overview 172

Market Revenue 173

TABLE 63 U S MARKET FOR NMR SHIFT REAGENTS, THROUGH

2016 ($ MILLIONS) 173

FIGURE 42 U S MARKET FOR NMR SHIFT REAGENTS, 2009-2016 ($

MILLIONS) 173

Others 174

Market Overview 174

Market Revenue 174

TABLE 64 U S MARKET FOR OTHER CHIRAL ANALYSIS, THROUGH

2016 ($ MILLIONS) 175

FIGURE 43 U S MARKET FOR OTHER CHIRAL ANALYSIS, 2009-2016

($ MILLIONS) 175

INDUSTRY LEADER MARKET SHARES 175

CHIRAL INTERMEDIATES 175

TABLE 65 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL INTERMEDIATES IN THE U S , 2010 (%) 176

FIGURE 44 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL INTERMEDIATES IN THE U S , 2010 (%) 177

CHIRAL CHEMICAL CATALYSTS 177

TABLE 66 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL CHEMICAL CATALYSTS IN THE U S , 2010 (%) 178

FIGURE 45 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL CHEMICAL CATALYSTS IN THE U S , 2010 (%) 178

CHIRAL BIOCATALYSTS 179

TABLE 67 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL BIOCATALYSTS IN THE U S , 2010 (%) 179

FIGURE 46 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL BIOCATALYSTS IN THE U S , 2010 (%) 180

CHIRAL AUXILIARIES 180

TABLE 68 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL AUXILIARIES IN THE U S , 2010 (%) 181

FIGURE 47 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL AUXILIARIES IN THE U S , 2010 (%) 181

OTHER SYNTHETIC MATERIALS 182

TABLE 69 MANUFACTURER/SUPPLIER MARKET SHARES OF

OTHER SYNTHETIC MATERIALS IN THE U S , 2010 (%) 182

FIGURE 48 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL SYNTHETIC MATERIALS IN THE U S , 2010 (%) 182

CHIRAL COLUMNS AND STATIONARY PHASES 183

TABLE 70 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL COLUMNS AND STATIONARY PHASES IN THE U S , 2010

(%) 183

FIGURE 49 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL COLUMNS AND STATIONARY PHASES IN THE U S , 2010

(%) 184

CHIRAL RESOLVING/CRYSTALLIZING AGENTS 184

TABLE 71 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL RESOLVING/CRYSTALLIZING AGENTS IN THE U S , 2010

(%) 185

FIGURE 50 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL RESOLVING/CRYSTALLIZING AGENTS IN THE U S , 2010

(%) 185

SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS 185

TABLE 72 MANUFACTURER/SUPPLIER MARKET SHARES OF

SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN THE

U S , 2010 (%) 186

FIGURE 51 MANUFACTURER/SUPPLIER MARKET SHARES OF

SOLVENT EXTRACTION REAGENTS AND INSTRUMENTS IN THE

U S , 2010 (%) 186

FIGURE 51 (CONTINUED) 187

CHIRAL ANALYSIS INSTRUMENTS 187

TABLE 73 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL ANALYSIS INSTRUMENTS IN THE U S , 2010 (%) 187

TABLE 73 (CONTINUED) 188

FIGURE 52 MANUFACTURER/SUPPLIER MARKET SHARES OF

CHIRAL ANALYSIS INSTRUMENTS IN THE U S , 2010 (%) 188

CHAPTER TEN: MARKET BY INDUSTRY APPLICATION 189

INTRODUCTION 189

CHIRAL TECHNOLOGY MARKET BY INDUSTRY 189

TABLE 74 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

SALES BY INDUSTRY, 2010 (%) 190

FIGURE 53 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

SALES BY INDUSTRY, 2010 (%) 190

PHARMACEUTICALS 190

Pharmaceuticals (Continued) 191

TABLE 75 CHIRAL DRUGS FROM THERAPEUTIC CLASSES 192

TABLE 76 ENANTIOPURE DRUGS 192

TABLE 76 (CONTINUED) 193

TABLE 76 (CONTINUED) 194

Market Revenue 194

TABLE 77 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS TO THE PHARMACEUTICAL INDUSTRY BY PRODUCT

TYPE, THROUGH 2016 ($ MILLIONS) 194

FIGURE 54 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS TO THE PHARMACEUTICAL INDUSTRY BY PRODUCT

TYPE, 2009-2016 ($ MILLIONS) 195

Market Share 195

TABLE 78 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED BY THE PHARMACEUTICAL

INDUSTRY, 2010 (%) 196

FIGURE 55 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

IN THE PHARMACEUTICAL INDUSTRY BY PRODUCT TYPE, 2010

(%) 196

TABLE 79 U S SALES OF TOP 10 CHIRAL DRUGS, 2010 ($

MILLIONS) 197

BIOCHEMICALS 197

Amino Acids 198

Hydroxy Acids 198

Oligonucleotides 198

Peptides 199

Oligosaccharides 199

Vitamins 200

Market Revenues 200

TABLE 80 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS TO THE BIOCHEMICAL INDUSTRY, THROUGH 2016

($ MILLIONS) 200

FIGURE 56 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS TO THE BIOCHEMICAL INDUSTRY, 2009-2016 ($

MILLIONS) 201

Market Share 201

TABLE 81 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED IN THE BIOCHEMICAL INDUSTRY,

2010 (%) 202

FIGURE 57 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED IN THE BIOCHEMICAL INDUSTRY,

2010 (%) 202

PESTICIDES/AGROCHEMICAL INDUSTRY 202

Pesticides/Agrochemical … (Continued) 203

TABLE 82 CHIRAL PESTICIDES 204

Pesticides/Agrochemical … (Continued) 205

Market Revenues 206

TABLE 83 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS IN THE AGROCHEMICAL INDUSTRY, THROUGH 2016

($ MILLIONS) 206

FIGURE 58 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS IN AGROCHEMICAL INDUSTRY, THROUGH 2016 ($

MILLIONS) 207

Market Share 207

TABLE 84 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED IN THE AGROCHEMICAL

INDUSTRY, 2010 (%) 207

FIGURE 59 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED IN THE AGROCHEMICAL

INDUSTRY, 2010 (%) 208

OTHER INDUSTRIES 208

Aromas and Fragrances 208

Aromas and Fragrances (Continued) 209

TABLE 85 CHIRAL AROMA COMPOUNDS 210

Liquid Crystals 210

Liquid Crystals (Continued) 211

Polymers 212

Market Revenues 213

TABLE 86 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS IN OTHER INDUSTRIES, THROUGH 2016 ($

MILLIONS) 213

FIGURE 60 GLOBAL SALES OF CHIRAL TECHNOLOGY ENABLING

PRODUCTS IN OTHER INDUSTRIES, THROUGH 2016 ($

MILLIONS) 214

Market Share 214

TABLE 87 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED IN OTHER INDUSTRIES, 2010 (%) 215

FIGURE 61 GLOBAL MARKET SHARES OF CHIRAL TECHNOLOGY

ENABLING PRODUCTS USED IN OTHER INDUSTRIES, 2010 (%) 215

CHAPTER ELEVEN: PATENT ANALYSIS 216

PATENTS BY YEAR 216

TABLE 88 U S PATENTS FOR CHIRAL PRODUCTS BY YEAR, 2009

TO OCT 2011 (NO ) 217

PATENTS BY TECHNOLOGY 217

TABLE 89 U S PATENTS FOR CHIRAL PRODUCTS BY

TECHNOLOGY, 2009 TO OCT 2011 (NO ) 218

FIGURE 62 U S PATENTS FOR CHIRAL PRODUCTS BY

TECHNOLOGY, 2009 TO OCT 2011 (NO ) 218

PATENTS BY TYPE 218

TABLE 90 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE, 2009

TO OCT 2011 (NO ) 219

FIGURE 63 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE, 2009

TO OCT 2011 (NO ) 219

TABLE 91 U S PATENTS FOR CHIRAL RESOLUTION BY TYPE, 2009

TO OCT 2011 (NO ) 220

FIGURE 64 U S PATENTS FOR CHIRAL RESOLUTION BY TYPE,

2009 TO OCT 2011 (NO ) 220

TABLE 92 U S PATENTS FOR CHIRAL ANALYSIS, 2009 TO OCT 2011

(NO ) 221

FIGURE 65 U S PATENTS BY TYPE FOR CHIRAL ANALYSIS, 2009

TO OCT 2011 (NO ) 221

PATENTS BY COMPANY 222

TABLE 93 U S PATENTS FOR CHIRAL SYNTHESIS BY COMPANY,

2009 TO OCT 2011 (NO ) 222

TABLE 93 (CONTINUED) 223

TABLE 94 U S PATENTS FOR CHIRAL RESOLUTION BY COMPANY,

2009 TO OCT 2011 (NO ) 224

TABLE 95 U S PATENTS FOR CHIRAL ANALYSIS BY COMPANY,

2009 TO OCT 2011 (NO ) 225

PATENTS BY COUNTRY 225

TABLE 96 U S PATENTS FOR CHIRAL SYNTHESIS BY COUNTRY,

2009 TO OCT 2011 (NO ) 225

TABLE 96 (CONTINUED) 226

TABLE 97 SHARES OF U S CHIRAL SYNTHESIS PATENTS BY

COUNTRY, 2009 TO OCT 2011 (%) 226

TABLE 97 (CONTINUED) 227

TABLE 98 U S PATENTS FOR CHIRAL RESOLUTION/SEPARATION

BY COUNTRY, 2009 TO OCT 2011 (NO ) 227

TABLE 99 SHARES OF U S CHIRAL RESOLUTION/SEPARATION

PATENTS BY COUNTRY, 2009 TO OCT 2011 (%) 228

TABLE 100 U S PATENTS FOR CHIRAL ANALYSIS BY COUNTRY,

2009 TO OCT 2011 (NO ) 228

TABLE 101 SHARES OF U S CHIRAL ANALYSIS PATENTS BY

COUNTRY, 2009 TO OCT 2011 (%) 229

PATENTS BY ASSIGNEE 229

TABLE 102 U S PATENTS FOR CHIRAL SYNTHESIS BY TYPE OF

ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 229

TABLE 103 U S PATENTS FOR CHIRAL RESOLUTION/SEPARATION

BY TYPE OF ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 230

TABLE 104 U S PATENTS FOR CHIRAL ANALYSIS BY TYPE OF

ASSIGNEE/END USER, 2009 TO OCT 2011 (NO ) 230

CHAPTER TWELVE: CURRENT CHIRAL MARKET ENVIRONMENT 231

INTRODUCTION 231

MARKET TRENDS IN THE ASYMMETRIC SYNTHESIS MARKET 232

MARKET TRENDS IN THE ASYMMETRIC SYNTHESIS MARKET 233

MARKET TRENDS IN CHIRAL RESOLUTION 234

MARKET TRENDS IN CHIRAL ANALYSIS 235

MARKET TRENDS IN CHIRAL … (CONTINUED) 236

MARKET TRENDS IN CHIRAL … (CONTINUED) 237

CHAPTER THIRTEEN: COMPANY PROFILES 238

3B SCIENTIFIC CORP 238

ABA CHEMICALS CORP 238

AESICA PHARMACEUTICALS LTD 239

AGILENT TECHNOLOGIES 239

ALLIED INDUSTRIAL CORP LTD 240

ALMAC GROUP LTD 240

AMPAC FINE CHEMICALS LLC 241

ARCH PHARMALABS LTD 241

ARRAN CHEMICAL CO LTD 242

AVANTIUM TECHNOLOGIES BV 243

AVANTOR PERFORMANCE MATERIALS 243

BACHEM AMERICAS 244

BASF SE 245

BAYER AG 245

BECKMAN COULTER INC 246

BIOCATALYSTS LTD 247

BOULDER SCIENTIFIC CO 247

BRUKER AXS GMBH 248

CAMBREX CORP 249

CARBOSYNTH LTD 250

CHEMTURA CORP 250

CHIRAL BIOSCIENCES LTD 251

CHIRAL MANAGEMENT 251

CHIRAL TECHNOLOGIES INC 252

CHIRAL TECHNOLOGIES EUROPE 252

CHIRALVISION BV 253

CHIROTECH TECHNOLOGY LTD 253

CHONGQING CHIRAL BIOCATALYSIS TECHNOLOGY CO LTD 254

CHROMACOL LTD 254

CHROMTECH GESELLSCHAFT FÜR ANALYTISCHE

MEßTECHNIK MBH 255

CODEXIS INC 255

CORDEN PHARMA SWITZERLAND LLC 256

CYTEC INDUSTRIES INC 257

DAICEL CORP 258

DAINIPPON SUMITOMO PHARMA CO LTD 258

DIONEX CORP 259

DOW CHEMICAL CO 260

DOW PHARMACEUTICAL SCIENCES 260

DSM PHARMACEUTICAL PRODUCTS 261

ENZYTECH CO LTD 262

EVOCATAL GMBH 262

FARBEN-CHEM EUROPE LTD 263

GENENCOR INTERNATIONAL INC 263

GILSON INC 264

JASCO INC 264

JOHNSON MATTHEY PLC 265

KANEKA CORP 266

KEMFINE LTD 267

KOCH MODULAR PROCESS SYSTEMS 267

LANXESS AG 268

LASERCHROM HPLC LABORATORIES LTD 269

LG CHEM EUROPE GMBH 269

LONZA 270

LOUSTON INTERNATIONAL INC 270

MACHEREY-NAGEL GMBH & CO KG 271

MARRESEARCH GMBH 271

MEGA S N C 272

MERCK KGAA 272

NOVASEP 273

NOVOZYMES A/S 274

OUTOTEC OYJ 274

PANALYTICAL INC 275

PDR-CHIRAL LLC 276

PERKINELMER 276

PHENOMENEX INC 277

PROZOMIX LTD 278

RARE EARTH PRODUCTS INC 278

REGIS TECHNOLOGIES INC 279

RHODIA INC USA 279

ROCHE APPLIED SCIENCE 280

ROUSSELET CENTRIFUGATION SA 281

RUDOLPH INSTRUMENTS 281

SHIMADZU CORP 282

SIGMA-ALDRICH 282

SILICYCLE 283

STREM CHEMICALS INC 284

SUPELCO INC 285

SYNQUEST LABORATORIES INC 285

SYNTHETECH INC 286

SYMRISE AG 286

TAKEDA PHARMACEUTICAL CO LTD 287

TCI AMERICA 288

TAKASAGO INTERNATIONAL CORP 289

THERMO FISHER SCIENTIFIC 289

VERENIUM CORP 290

WUXI APPTEC CO LTD 291

YAMAKAWA CHEMICAL 292

YMC AMERICA INC 292

ZHEJIANG CHIRAL MEDICINE CHEMICALS CO LTD 293

ZIRCHROM SEPARATIONS INC 293

APPENDIX: ABBREVIATIONS 294

ABBREVIATIONS 294

ABBREVIATIONS (CONTINUED) 295

ABBREVIATIONS (CONTINUED) 296

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Diagnostics Industry: Global Markets for Chiral Technology -- Focus on the U.S.

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