Increasing Use of Nanobiotechnology by the Pharmaceutical and Biotechnology Industries Anticipated?

Nanobiotechnologies Applications, Markets and Companies

Oct 07, 2004, 01:00 ET from Research and Markets

    DUBLIN, Ireland, Oct. 7 /PRNewswire/ -- Nanotechnology is the creation and
 utilization of materials, devices, and systems through the control of matter
 on the nanometer-length scale (a nanometer is one billionth of a meter.
 Nanobiotechnology, an integration of physical sciences, molecular engineering,
 biology, chemistry and biotechnology holds considerable promise of advances in
 pharmaceuticals and healthcare. The report starts with an introduction to
 various techniques and materials that are relevant to nanobiotechnology. It
 includes some of the physical forms of energy such as nanolasers. Some of the
 technologies are scaling down such as microfluidics to nanofluidic biochips
 and others are constructions from bottom up. Application in life sciences
 research, particularly at the cell level sets the stage for role of
 nanobiotechnology in healthcare in subsequent chapters.
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     Some of the earliest applications are in molecular diagnostics.
 Nanoparticles, particularly quantum dots, are playing important roles. In
 vitro diagnostics, does not have any of the safety concerns associated with
 the fate of nanoparticles introduced into the human body. Numerous nanodevices
 and nanosystems for sequencing single molecules of DNA are feasible. Various
 nanodiagnostics that have been reviewed will improve the sensitivity and
 extend the present limits of molecular diagnostics.
     An increasing use of nanobiotechnology by the pharmaceutical and
 biotechnology industries is anticipated. Nanotechnology will be applied at all
 stages of drug development -- from formulations for optimal delivery to
 diagnostic applications in clinical trials. Many of the assays based on
 nanobiotechnology will enable high- throughput screening. Some of
 nanostructures such as fullerenes are themselves drug candidates as they allow
 precise grafting of active chemical groups in three-dimensional orientations.
 The most important pharmaceutical applications are in drug delivery. Apart
 from offering a solution to solubility problems, nanobiotechnology provides
 and intracellular delivery possibilities. Skin penetration is improved in
 transdermal drug delivery. A particularly effective application is as nonviral
 gene therapy vectors. Nanotechnology has the potential to provide controlled
 release devices with autonomous operation guided by the needs.
     Nanomedicine is now within the realm of reality starting with
 nanodiagnostics and drug delivery facilitated by nanobiotechnology. Miniature
 devices such as nanorobots could carry out integrated diagnosis and therapy by
 refined and minimally invasive procedures, nanosurgery, as an alternative to
 crude surgery. Nanotechnology will markedly improve the implants and tissue
 engineering approaches as well.
     There is some concern about the safety of nanoparticles introduced in the
 human body and released into the environment. Research is underway to address
 these issues. As yet there are no FDA directives to regulate nanobiotechnology
 but as products are ready to enter market, these are expected to be in place.
     Future nanobiotechnology markets are calculated on the basis of the
 background markets in the areas of application and the share of this market by
 new technologies and state of development at any given year in the future.
 This is based on a comprehensive and thorough review of the current status of
 nanobiotechnology, research work in progress and anticipated progress. There
 is definite indication of large growth of the market but it will be uneven and
 cannot be plotted as a steady growth curve. The largest expansion is expected
 between the years 2010 and 2015.
     Marketing estimates are given according to areas of application,
 technologies and geographical distribution. Profiles of 125 companies, out of
 over 500 involved in this area, are included in the last chapter along with
 their collaborations.
     Report Contents:
      0 Executive Summary 11
      1  Basics of Nanobiotechnology 13
      2  Technologies 17
      3  Applications in Life Sciences 39
      4  Nanomolecular Diagnostics 53
      5  Nanobiotechnology in Drug Discovery & Development 73
      6  Nanobiotechnology in Drug Delivery 79
      7  Clinical Applications of Nanobiotechnology 111
      8  Regulatory and Safety issues 133
      9  Nanobiotechnology Markets 137
      10 Nanobiotech Companies 147
      11 References 285
     For a complete index of this report click on
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