MediPoint: Total Ankle Replacement - Global Analysis and Market Forecasts



 

NEW YORK, Dec. 11, 2013 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:


MediPoint: Total Ankle Replacement - Global Analysis and Market Forecasts
http://www.reportlinker.com/p01921058/MediPoint-Total-Ankle-Replacement---Global-Analysis-and-Market-Forecasts.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic

MediPoint: Total Ankle Replacement - Global Analysis and Market Forecasts


Summary

Ankle arthritis is a severe and debilitating problem with notable increasing prevalence in both the developed and developing world. In a society constantly seeking out a modern lifestyle, sports-related injuries, trauma, aging, and obesity are contributing to an increased incidence of ankle arthritis. Total ankle replacement (TAR) enables implantation of prosthesis within the diseased native ankle joint to help patients maintain their ankles' range of motion. Promising results of newer generation prostheses revived interest in TAR and fueled further innovations in the prosthetic design. After decades of trial and error, TAR is now becoming a promising option for late-stage ankle arthritis patients as an alternative to ankle fusion, which has historically been presumed to be the gold-standard procedure. This report focuses on the TAR markets in the US, the EU5, Japan, Brazil, China and India. This report identifies unmet needs in the market, surgeon attitudes towards current TAR prostheses, and the future of TAR in the face of rapid technological advancement.


Highlights

Key Questions Answered

- Ankle arthritis incidence is expected to increase during the forecast period. (Q).What is the cost of ankle arthritis? (Q).How will changing demographics and lifestyles affect the incidence of ankle arthritis?
- Long-term results following successful early ankle fusion have brought to light somewhat disappointing long-term satisfaction rates. (Q).What shifts are happening in surgeon attitudes towards ankle fusion in the treatment of late-stage ankle arthritis?
- TAR is becoming an increasingly popular alternative to ankle fusion lately, as professional and commercial interest intensifies and long-term effectiveness becomes available. (Q).What is the current perception and adoption of this technique in the major markets?
- By far only one three-component mobile-bearing TAR implant has been approved by the Food and Drug Administration (FDA) to be used in the US. (Q).Is it still in debate within the foot and ankle community whether mobile-bearing TAR implants generate better clinical outcomes than fixed-bearing ones?
- Today approximately 10–15 TAR prostheses are in use throughout the world. Current prosthesis design features a better appreciation of ankle anatomy and an attempt to minimize bone resection. (Q).Which features of TAR devices are most desirable by surgeons? (Q).What are the unmet needs? (Q).How can device manufacturers differentiate themselves from the competition?


Reasons to buy

- "What Physicians Think" quotes provide a unique insight into how healthcare professionals are reacting to events within the industry, and what their responses could mean for industry strategists. In this report you will understand the perceptions of leading Orthopedic Surgeons and Podiatrists from around the world. This information is essential for all strategic decision makers in every organization allowing them to act on high quality information.

Table of Contents

1 Table of Contents 6
1.1 List of Tables 10
1.2 List of Figures 12
2 Introduction 14
2.1 Catalyst 14
3 Disease Overview 15
3.1 Anatomy and Physiology 15
3.2 Pathophysiology 16
3.2.1 Overview 16
3.2.2 Post-Traumatic Arthritis 17
3.2.3 Inflammatory Arthritis 18
3.2.4 Primary Osteoarthritis 18
3.2.5 Others 19
3.3 Clinical Presentation 19
3.3.1 Symptoms 19
3.3.2 Diagnosis 20
3.4 Clinical Outcomes 21
3.4.1 Overview 21
3.4.2 Conservative Treatments 21
3.4.3 Joint-Preserving Surgeries 22
3.4.4 Definitive Procedures 25
3.5 Epidemiology 29
3.5.1 Prevalence 29
3.5.2 Treatments 30
3.6 Economic Impact 31
3.6.1 Economic Impact in the US 32
3.6.2 Economic Impact in Europe 33
3.6.3 Economic Impact in Rest of the World 33
4 Competitive Assessment 34
4.1 Overview 34
4.2 Competitive Assessment 35
4.3 Two-Component Fixed-Bearing 36
4.3.1 Agility LP 36
4.3.2 Salto Talaris 38
4.3.3 INBONE II 40
4.3.4 TNK 43
4.3.5 Zimmer Trabecular Metal Total Ankle 44
4.4 Three-Component Mobile-Bearing 46
4.4.1 Scandinavian Total Ankle Replacement (STAR) 46
4.4.2 Mobility 48
4.4.3 Salto 50
4.4.4 HINTEGRA 52
4.4.5 BOX (Bologna-Oxford) 54
4.4.6 Zenith 56
4.4.7 CCI Evolution 58
5 Unmet Needs 60
5.1 Long-Term Follow-Up 61
5.2 Commitment to Medical Education 61
5.3 Advanced Biological Fixation 62
5.4 Minimal Bone Resection 64
5.4.1 Tibial Component 64
5.4.2 Talar Component 65
5.5 Mobile-Bearing versus Fixed-Bearing 65
5.6 Bespoke Instrumentation 67
5.7 Custom Prostheses 67
5.8 Revision Components 68
6 Pipeline Products 69
6.1 Overview 69
6.2 INBONE II Total Ankle with Calcaneal Stem Fixation 69
6.2.1 Overview 69
6.2.2 SWOT Analysis 70
6.3 Akilos Total Ankle System 71
6.3.1 Overview 71
6.3.2 SWOT Analysis 72
7 Industry Overview 73
7.1 Procedure Trends 73
7.1.1 US 73
7.1.2 Europe 74
7.1.3 Asia-Pacific 75
7.1.4 South America 76
7.2 Market Access 77
7.2.1 Regulatory Process 77
7.2.2 Adoption 79
7.3 Reimbursement Trends 81
7.3.1 US 81
7.3.2 Europe 83
7.3.3 Asia-Pacific 86
7.3.4 South America 87
7.4 Regulatory Issues/Recalls 87
7.4.1 No Custom Devices for DePuy's Agility Total Ankle Prosthesis in the US 87
7.4.2 Medical Device Alert for Biomet's Ankle Evolutive System (AES) used in the UK 88
7.5 Mergers & Acquisitions/Key Partnerships 88
8 Current and Future Players 90
8.1 Overview 90
8.2 Trends in Corporate Strategy 90
8.3 Company Profiles 91
8.3.1 Small Bone Innovation, Inc. 91
8.3.2 DePuy Synthes 93
8.3.3 Tornier N.V. 95
8.3.4 Wright Medical Group, Inc. 96
8.3.5 Integra LifeSciences 99
8.3.6 Zimmer Holdings, Inc. 100
8.3.7 Corin Group 103
8.3.8 KYOCERA Medical Corporation 104
8.3.9 MatOrtho 106
8.3.10 Implants International 107
8.3.11 Other Companies 108
9 Market Drivers, Opportunities, and Barriers 109
9.1 Market Drivers 109
9.1.1 Superiority to Ankle Fusion 109
9.1.2 Rising Prevalence 110
9.1.3 Expanded Insurance Coverage 111
9.1.4 Availability of Long-Term Data 112
9.1.5 Increased Patient Awareness 112
9.1.6 Expected Launch of CE-Marked Devices 113
9.2 Opportunities 113
9.2.1 Expanded Indications 113
9.2.2 Advanced Biological Fixation Approaches 114
9.2.3 Revision TAR 114
9.2.4 Demand for Custom Prostheses 115
9.2.5 Demand for a Comprehensive Foot and Ankle Product Portfolio 115
9.2.6 Emerging Markets 116
9.3 Market Barriers 116
9.3.1 Preoperative Patient Selection 116
9.3.2 Long Learning Curve 117
9.3.3 Complications 118
9.3.4 Cost 118
9.3.5 Reimbursement 119
9.3.6 Substitutes 119
10 Country Outlooks and Forecasts 120
10.1 Major Markets Overview 120
10.2 US 122
10.2.1 US Market Analysis 122
10.3 France 124
10.3.1 France Market Analysis 124
10.4 Germany 126
10.4.1 Germany Market Analysis 126
10.5 Italy 127
10.5.1 Italy Market Analysis 127
10.6 Spain 129
10.6.1 Spain Analysis 129
10.7 UK 130
10.7.1 UK Market Analysis 130
10.8 Japan 132
10.8.1 Japan Market Analysis 132
10.9 Brazil 134
10.9.1 Brazil Market Analysis 134
10.10 China 135
10.10.1 China Market Analysis 135
10.11 India 137
10.11.1 India Market Analysis 137
11 Appendix 139
11.1 Abbreviations 139
11.2 Bibliography 140
11.3 Methodology 147
11.3.1 Coverage 147
11.3.2 Secondary Research 147
11.3.3 Primary Research 148
11.3.4 Forecasting Methodology 149
11.4 Physicians and Specialists Included in this Study 150
11.5 Physician Survey 151
11.6 About the Authors 151
11.6.1 Analysts 151
11.6.2 Global Head of Healthcare 152
11.7 About MediPoint 152
11.8 About GlobalData 153
11.9 Contact Us 153
11.10 Disclaimer 153



List of Tables

Table 1: Common Clinical Symptoms of Ankle Arthritis 19
Table 2: Indications and Contraindications of TAR 28
Table 3: Direct and Indirect Costs of Arthritis 31
Table 4: Currently Marketed Total Ankle Replacement Implants 34
Table 5: Product Profile - Agility LP 37
Table 6: SWOT Analysis - Agility LP 38
Table 7: Product Profile - Salto Talaris 39
Table 8: SWOT Analysis - Salto Talaris 40
Table 9: Product Profile - INBONE II 42
Table 10: SWOT Analysis - INBONE II 42
Table 11: Product Profile - TNK 43
Table 12: SWOT Analysis - TNK 44
Table 13: Product Profile - Zimmer Trabecular Metal Total Ankle 45
Table 14: SWOT Analysis - Zimmer Trabecular Metal Total Ankle 46
Table 15: Product Profile - STAR 47
Table 16: SWOT Analysis - STAR 48
Table 17: Product Profile - Mobility 49
Table 18: SWOT Analysis - Mobility 50
Table 19: Product Profile - Salto 51
Table 20: SWOT Analysis - Salto 51
Table 21: Product Profile - HINTEGRA 53
Table 22: SWOT Analysis - HINTEGRA 53
Table 23: Product Profile - BOX 55
Table 24: SWOT Analysis - BOX 55
Table 25: Product Profile - Zenith 57
Table 26: SWOT Analysis - Zenith 57
Table 27: Product Profile - CCI Evolution 58
Table 28: SWOT Analysis - CCI Evolution 59
Table 29: Overall Unmet Needs - Current Level of Attainment and Importance (n=30) 60
Table 30: Coating Methods of Currently Marketed TAR Implants 63
Table 31: Product Profile - INBONE II Total Ankle with Calcaneal Stem Fixation 69
Table 32: SWOT Analysis of INBONE II Total Ankle with Calcaneal Stem Fixation 70
Table 33: Product Profile - Akilos 72
Table 34: SWOT Analysis - Akilos 72
Table 35: 2011 Medicare National Payment Average for Total Ankle Replacement 82
Table 36: Company Profile - Small Bone Innovations 91
Table 37: Portfolio Assessment - Small Bone Innovations, 2013 91
Table 38: SBi's Foot and Ankle Business SWOT Analysis, 2013 92
Table 39: Company Profile - DePuy Synthes Companies 93
Table 40: DePuy's Total Ankle Replacement Portfolio Assessment, 2013 94
Table 41: DePuy's Foot and Ankle Business SWOT Analysis, 2013 94
Table 42: Company Profile - Tornier N.V. 95
Table 43: Tornier's Total Ankle Replacement Portfolio Assessment, 2013 95
Table 44: Tornier's Foot and Ankle Business SWOT Analysis, 2013 96
Table 45: Company Profile - Wright Medical Group 97
Table 46: Wright Medical's Total Ankle Replacement Portfolio Assessment, 2013 97
Table 47: Wright Medical's Foot and Ankle Business SWOT Analysis, 2013 98
Table 48: Company Profile - Integra LifeSciences 99
Table 49: Integra's Total Ankle Replacement Portfolio Assessment, 2013 99
Table 50: Integra's Foot and Ankle Business SWOT Analysis, 2013 100
Table 51: Company Profile - Zimmer Holdings 101
Table 52: Zimmer Holding's Total Ankle Replacement Portfolio Assessment, 2013 101
Table 53: Zimmer's Foot and Ankle Business SWOT Analysis, 2013 102
Table 54: Company Profile - Corin Group 103
Table 55: Corin Group's Total Ankle Replacement Portfolio Assessment, 2013 103
Table 56: Corin Group's Foot and Ankle Business SWOT Analysis, 2013 104
Table 57: Company Profile - KYOCERA Medical Corporation 104
Table 58: KYOCERA Medical's Total Ankle Replacement Portfolio Assessment, 2013 105
Table 59: KYOCERA Medical's Orthopedic Devices Business SWOT Analysis, 2013 105
Table 60: Company Profile - MatOrtho 106
Table 61: MatOrtho's Total Ankle Replacement Portfolio Assessment, 2013 106
Table 62: MatOrtho's Orthopedic Devices Business SWOT Analysis, 2013 107
Table 63: Company Profiles - Implants International 107
Table 64: Implants International's Total Ankle Replacement Portfolio Assessment, 2013 108
Table 65: Implants International's Orthopedic Devices Business SWOT Analysis, 2013 108
Table 66: Portfolio Assessment - Other Players in Total Ankle Replacement Market, 2013 108
Table 67: Advantages and Disadvantages of Ankle Fusion and Total Ankle Replacement 110
Table 68: Sales Forecasts for TAR in 10 Markets (2009-2018) 120
Table 69: Sales Forecasts for TAR in the US (2009-2018) 122
Table 70: Sales Forecasts for TAR in France (2009-2018) 124
Table 71: Sales Forecasts for TAR in Germany, 2009-2018 126
Table 72: Sales Forecasts for TAR in Italy (2009-2018) 127
Table 73: Sales Forecasts for TAR in Spain (2009-2018) 129
Table 74: Sales Forecasts for TAR in the UK (2009-2018) 130
Table 75: Sales Forecasts for TAR in Japan (2009-2018) 132
Table 76: Sales Forecasts for TAR in Brazil (2009-2018) 134
Table 77: Sales Forecasts for TAR in China (2009-2018) 136
Table 78: Sales Forecasts for TAR in India (2009-2018) 137
Table 79: Abbreviations 139
Table 80: Physicians Surveyed, By Country 151

1.2 List of Figures
Figure 1: Schematic Diagram of Ankle Anatomy 15
Figure 2: Ankle Arthritis Subtypes 16
Figure 3: Causes of Post-Traumatic Ankle Arthritis 17
Figure 4: Staged Treatment Approach of Ankle Arthritis 21
Figure 5: An Example of Ankle Distraction Arthroplasty 24
Figure 6: An Example of Ankle Fusion 25
Figure 7: An Example of a Total Ankle Replacement Implant 26
Figure 8: Population with Ankle Arthritis (2009-2018) 29
Figure 9: Treatment Modalities of Ankle Arthritis in Developed Countries 30
Figure 10: Treatment Modalities of Ankle Arthritis in Developing Countries 30
Figure 11: Estimated Costs of Ankle Arthritis, 2009-2018 32
Figure 12: Estimated Global Market for TAR Implants in 2011 35
Figure 13: Product Image - Agility LP 37
Figure 14: Product Image - Salto Talaris 39
Figure 15: Product Image - INBONE II 41
Figure 16: Product Image - TNK 43
Figure 17: Product Image - Zimmer Trabecular Metal Total Ankle 45
Figure 18: Product Image - STAR 47
Figure 19: Product Image - Mobility 49
Figure 20: Product Image - Salto 50
Figure 21: Product Image - HINTEGRA 52
Figure 22: Product Image - BOX 54
Figure 23: Product Image - Zenith 56
Figure 24: Product Image - CCI Evolution 58
Figure 25: Product Image - Akilos 71
Figure 26: TAR Procedure Volume in the US (2009-2018) 73
Figure 27: TAR Procedure Volume in Europe (2009-2018) 74
Figure 28: TAR Procedure Volume in Asia-Pacific (2009-2018) 75
Figure 29: TAR Procedure Volume in Brazil (2009-2018) 76
Figure 30: Global Sales Forecast for TAR Market (2009-2018) 120
Figure 31: 10 Market Sales for TAR by Region (2011-2018) 121
Figure 32: Sales Forecasts for TAR in the US (2009-2018) 122
Figure 33: Sales Forecasts for TAR in France (2009-2018) 125
Figure 34: Sales Forecasts for TAR in Germany (2009-2018) 126
Figure 35: Sales Forecasts for TAR in Italy (2009-2018) 128
Figure 36: Sales Forecasts for TAR in Spain (2009-2018) 129
Figure 37: Sales Forecasts for TAR in the UK (2009-2018) 131
Figure 38: TAR Market Share in the UK (2011) 132
Figure 39: Sales Forecasts for TAR in Japan (2009-2018) 133
Figure 40: Sales Forecast for TAR in Brazil (2009-2018) 134
Figure 41: Sales Forecasts for TAR in China (2009-2018) 136
Figure 42: Sales Forecasts for TAR in India (2009-2018) 137



Companies Mentioned

Small Bone Innovation, Inc.
DePuy Synthes
Tornier N.V.
Wright Medical Group, Inc.
Integra LifeSciences
Zimmer Holdings, Inc.
Corin Group
KYOCERA Medical Corporation
MatOrtho
Implants International



To order this report: MediPoint: Total Ankle Replacement - Global Analysis and Market Forecasts
http://www.reportlinker.com/p01921058/MediPoint-Total-Ankle-Replacement---Global-Analysis-and-Market-Forecasts.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic



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