Milestone Scientific Receives 510(k) Premarket Notification Acceptance From FDA for CompuFlo(TM) Computer Controlled Infusion Pump

Company to Pursue Strategic Relationships With Marketing Leaders in Medical


Jul 13, 2006, 01:00 ET from Milestone Scientific Inc.

    LIVINGSTON, N.J., July 13 /PRNewswire-FirstCall/ -- Milestone
 Scientific Inc. (Amex:   MSS), which develops, manufactures, and markets
 'intelligent' computer controlled local anesthetic delivery systems, today
 announced that it has received FDA 510(k) Premarket Notification acceptance
 for the marketing and sale of its CompuFlo(TM) Computer Controlled Infusion
     The CompuFlo Computer Controlled Infusion Pump utilizes pressure
 feedback data to monitor and regulate the delivery to patients of local
 anesthesia, medications and other fluids, and will serve as the foundation
 for the development of significant new medical and dental devices at
 Milestone Scientific Inc.
     "The receipt of 510(k) acceptance from the FDA represents a major step
 for Milestone in the commercialization process for our patented CompuFlo
 technology," stated Leonard Osser, Chief Executive Officer of Milestone
 Scientific Inc. "We are currently seeking partnership opportunities with
 major companies in the Regional Anesthesia market, especially in
 applications where safety is of paramount concern. We plan to initially
 target the $200 million-plus annual market for epidural injections that are
 administered to women during childbirth procedures in the U.S. Such
 injections are also used in the treatment of low back pain and pain in the
 lower extremities. CompuFlo's pressure sensing technology clearly
 identifies the epidural space for the doctor, thereby greatly reducing the
 risks of paralysis and other complications that can occur when physicians
 attempt to locate the epidural space using tactile senses."
     When administering epidural injections, it is critical to recognize the
 risks associated with the introduction of potentially neurotoxic substances
 into the subarachnoid space, from which 40% of spinal fluid is produced. If
 local anesthesia is injected into this space, instead of the epidural
 space, the patient may face a lifetime of agony due to adhesive
 arachnoiditis. This represents a potential risk for any patient undergoing
 an epidural injection today, because doctors must rely upon tactile "feel"
 to identify the epidural space.
     "Clinical studies using Milestone's CompuFlo Computer Controlled
 Infusion Pump in the administration of epidural anesthesia have provided
 highly encouraging results," noted Thomas Ronca, President and Chief
 Operating Officer of the Company. "We believe that, because of the risks
 associated with current epidural injection techniques, CompuFlo has the
 potential to become a 'standard of care' within the anesthesiology
 profession. Our next step is to identify and enter into strategic
 relationships with one or more marketing leaders in the medical device
     "The now-approved CompuFlo infusion pump also underlies the development
 of our Single-Tooth Anesthesia ("STA") device," continued Ronca. "We
 believe the STA device can revitalize our entire line of dental anesthetic
 delivery systems and promote significantly increased usage of our systems
 and their single-use handpieces."
     About Milestone Scientific Inc.
     Milestone Scientific Inc. is the developer, manufacturer and marketer
 of CompuMed(R) and CompuDent(R) computer controlled local anesthetic
 delivery systems. These systems comprise a microprocessor controlled drive
 unit as well as The Wand(R) handpiece, a single patient use product that is
 held in a pen-like manner for injections. The Company also sells the
 SafetyWand(R), which incorporates engineered sharps injury protection
 features to aid in the prevention of accidental needlesticks. Milestone has
 also developed proprietary consumer (Ionic White) and professional
 (CoolBlue) teeth whitening systems that were introduced to the market in
 early 2005.
     Milestone has also received broad United States patent protection on
 CompuFlo(TM), an enabling technology for computer controlled, pressure
 sensitive infusion, perfusion, suffusion and aspiration that provides real
 time displays of pressures, fluid densities and flow rates. CompuFlo
 advances the delivery to and/or removal from patients of local anesthesia,
 medications and other fluids, and the Company is pursuing market
 opportunities in a variety of medical and dental applications.
     The Company is headquartered in Livingston, New Jersey, and its common
 stock trades on the American Stock Exchange under the symbol "MSS".
     This press release contains forward-looking statements regarding the
 timing and financial impact of the Milestone's ability to implement its
 business plan, expected revenues and future success. These statements
 involve a number of risks and uncertainties and are based on assumptions
 involving judgments with respect to future economic, competitive and market
 conditions and future business decisions, all of which are difficult or
 impossible to predict accurately and many of which are beyond Milestone's
 control. Some of the important factors that could cause actual results to
 differ materially from those indicated by the forward-looking statements
 are general economic conditions, failure to achieve expected revenue
 growth, changes in our operating expenses, adverse patent rulings, FDA or
 legal developments, competitive pressures, changes in customer and market
 requirements and standards, and the risk factors detailed from time to time
 in Milestone's periodic filings with the Securities and Exchange
 Commission, including without limitation, Milestone's Annual Report on Form
 10-KSB for the year ended December 31, 2005. The forward looking-statements
 in this press release are based upon management's reasonable belief as of
 the date hereof. Milestone undertakes no obligation to revise or update
 publicly any forward-looking statements for any reason.
     Leonard Osser, CEO
     Milestone Scientific Inc.
     (973) 535-2717; (973) 535-2829 (Fax)
     Web site:

SOURCE Milestone Scientific Inc.