Comments from Decision Resources Group Analyst Bethany Christmann, Ph.D.:
- "Today's CIAS pipeline is sparse, owing in part to a history of failed trials—most recently Forum Pharmaceuticals' encenicline—which will prolong the high level of unmet need in this arena. However, a handful of companies have new drug candidates in mid-phase development, each aiming to be the first to capitalize on this large and wholly untapped commercial opportunity. More broadly, our findings indicate that any drug—approved or off-label, antipsychotic or other—that demonstrates an effect on CIAS symptoms and maintains an acceptable safety profile would have an advantage in the schizophrenia market."
- "On average, surveyed psychiatrists rated the overall level of unmet need in CIAS as high, similar to the need for drugs to treat the negative symptoms of schizophrenia, for which effective treatments also do not exist. Moreover, despite the numerous atypical antipsychotics approved to treat the positive symptoms of schizophrenia, the average unmet need score for positive symptoms was moderate—consistent with findings in other new DRG research highlighting the clinical shortcomings of available drugs, particularly in treatment-resistant patients. Perhaps not surprisingly, surveyed physicians indicated that a CIAS therapy's impact on psychiatric symptoms—whether worsening or improving the symptoms—will play an important role in prescribing decisions."
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SOURCE Decision Resources Group