Nanosphere Patent Portfolio Ranked Second Strongest in Micro- and Nanotech

Independent Analysis of Nanotechnology Industry Concludes Molecular

Diagnostics Company's Intellectual Property Pipeline Power Trails That of Only


Aug 30, 2005, 01:00 ET from Nanosphere, Inc.

    NORTHBROOK, Ill., Aug. 30 /PRNewswire/ -- Nanosphere, Inc., a
 nanotechnology-based molecular diagnostics company, today announced that a
 study of micro- and nanotechnology patent portfolios has ranked the company
 second overall in terms of pipeline power. The report, prepared by
 intellectual property consulting firm 1790 Analytics LLC and published in the
 July/August 2005 issue of Small Times, evaluates companies' portfolio strength
 based not only on number of patents issued, but also such factors as pipeline
 growth and originality.
     Only Hewlett-Packard was ranked higher than Nanosphere, indicating the
 exceptional quality of Nanosphere's intellectual property. Combined with the
 company's experienced management team and pressing market demand for more
 sensitive, easy-to-use molecular diagnostics technology, Nanosphere's patent
 portfolio clearly differentiates it from other venture-backed life sciences
     Enabled by proprietary nanoparticle technology, Nanosphere is
 commercializing its first product, the Verigene(R) System, to allow the
 simultaneous ultra-sensitive detection of nucleic acids and proteins. It is
 designed for use by researchers, clinicians and first responders in any lab
 setting or in the field. The unmatched sensitivity of the company's technology
 can lead to earlier detection of diseases such as cancer and cardiovascular
 disease and the development of new diagnostic tests for conditions such as
 Alzheimer's disease and other neurological disorders. The technology is also
 broadly applicable in pharmacogenomics, biohazard detection and food safety
     Nanosphere holds 34 U.S. patents, 16 of which were issued in 2004, and
 five international patents; it has more than 100 patent applications pending.
 The company has licensed exclusive rights from Northwestern University to
 existing inventions and certain technology developments in the area of
 nanoparticle probes for use in molecular diagnostics.
     William Moffitt, president and chief executive officer of Nanosphere,
 said: "We're focused on fundamentally altering the way molecular diagnostic
 testing is performed and to do that, we've made substantial investments in R&D
 and scientific talent. Those investments have resulted in extraordinarily
 strong IP holdings for the company and put us in a powerful position to
 advance detection of disease-associated proteins and nucleic acids."
     The 1790 Analytics study considered five indicators, and then arrived at
 rankings of overall pipeline power. It looked at the number of U.S. patents
 issued in 2004 related to micro- and nanotechnology; pipeline growth; impact,
 as measured by how frequently patents are cited by later patents; generality,
 or how useful a patent is among different fields; and originality.
     The report concluded Hewlett-Packard has the strongest portfolio, followed
 in order by Nanosphere, Agere Systems, Agilent Technologies and Intel. Of the
 companies in the top five, only Nanosphere is privately held.
     About Nanosphere, Inc.
     Nanosphere is redefining molecular diagnostics with a nanotechnology-based
 platform that will enable earlier detection and treatment of disease. The
 company's ultra-sensitive protein detection and direct genomic testing
 technologies permit the development of new biomarkers and measurement of
 existing biomarkers at concentrations undetectable by today's diagnostic
 technologies. The Verigene(R) System's simplicity, ease of use and low cost
 allow customers to perform molecular diagnostic testing in virtually any
 setting. Nanosphere is privately-held and based in Northbrook, Ill. Additional
 information is available at
      Ken Bahk, Ph.D.                         Jennifer Viera
      Nanosphere, Inc.                        Schwartz Communications, Inc.
      847-400-9000                            781-684-0770           

SOURCE Nanosphere, Inc.