PARSIPPANY, N.J., Sept. 17 /PRNewswire/ -- Results of a nationwide
survey of infertility patients undergoing an assisted reproductive
technology treatment (ART), such as in vitro fertilization, revealed that
patients prefer ENDOMETRIN(R) (progesterone) Vaginal Inserts to
progesterone-in-oil (PIO) injections, and to all other vaginal progesterone
supplements. The reasons cited most frequently for their preference
included easy, convenient and pain-free administration.
Adequate progesterone support is considered extremely important for a
successful pregnancy. Since natural progesterone production may be
compromised by ART, progesterone supplements are used extensively for
luteal phase and early pregnancy support. There are several forms: oral,
injection, and vaginal -- tablet inserts, vaginal capsules, suppositories
"The survey confirms what we hear all the time from patients -- that
when they reach the final stage of their IVF treatment, the last thing they
want is another series of shots or inconvenient treatments," said Christine
Stroup, RN. "Our patients are very pleased with ENDOMETRIN because it's
simple to use and very convenient."
"I've tried just about every progesterone treatment available, and was
so happy to find one that didn't hurt, like shots, and wasn't messy, like
gels and suppositories," said Victoria Knapp, IVF patient. "After all those
cycles of treatment I went through, it was a relief to find one that was so
simple to use."
The Evaluation of Attitudes and Satisfaction with Endometrin Survey of
212 patients was commissioned by Ferring Pharmaceuticals Inc. to compare
patient satisfaction with ENDOMETRIN, the most recent progesterone
supplement to enter the market, with all other progesterone supplements.
Key Survey Findings
-- More than 90 percent of patients would recommend ENDOMETRIN to a friend
undergoing infertility treatment, 84 percent would request it for their
next treatment cycle, and 93 percent found the dosing regimen easy to
fit into their daily routine. When asked to describe it in three words,
the most common were: "easy, convenient, painless and
-- The vast majority found the vaginal inserts more convenient (87
percent), comfortable (89 percent), and easier to administer (95
percent) compared with injections, taken by 154 respondents. Of the
women who needed a partner to administer the shots, most (65 percent)
said their partner felt anxious about it.
-- Of the 62 women who used the capsules administered vaginally, most said
ENDOMETRIN was more convenient (74 percent), comfortable (nearly 70
percent), and easier to administer (83 percent).
-- Patients found suppositories, made by the pharmacy, awkward to
administer without an applicator. Of the 83 women who used them, nearly
90 percent said they melted or leaked, and more than half said they
-- Nearly 80 percent of the 26 gel users said gel created build-up, nearly
50 percent found gel messy to administer and more than one-third said it
-- While 20 of the 40 women who used the oral form preferred the
administration convenience of ENDOMETRIN and 13 preferred the oral
supplement, the oral form is widely considered less effective than other
Nurses at more than 60 designated fertility centers across the country
selected qualified patients who had used or were about to start ENDOMETRIN
in an IVF or ovulation induction cycle. Patients must also have used a
different progesterone supplement in a previous or current cycle. The
survey reflects the patient's most recent treatment cycle. The majority of
the 212 patients were 40-years-old or younger; nearly 40 percent had been
in fertility treatment for more than two years.
ENDOMETRIN administered as a progesterone vaginal insert is indicated
to support embryo implantation and early pregnancy by supplementation of
corpus luteal function as part of an Assisted Reproductive Technology (ART)
treatment for infertile women.
Only physicians thoroughly familiar with infertility treatment should
prescribe ENDOMETRIN. In clinical trials (n=808), adverse reactions that
occurred at a rate greater than or equal to two percent included: uterine
spasm (3% to 4%) and vaginal bleeding (3%). Vaginal irritation, itching,
burning or discomfort, urticaria, and peripheral edema were reported at an
incidence of less than two percent. ENDOMETRIN is expected to have adverse
reactions to other drugs containing progesterone (breast tenderness,
bloating, mood swings, irritability, and drowsiness).
About Ferring Pharmaceuticals
Ferring Pharmaceuticals, part of the Ferring Group, a privately owned,
international pharmaceutical company, manufactures and markets the largest
family of fertility treatments of any manufacturer in the U.S. The Company
markets MENOPUR(R) (menotropins for injection, USP), BRAVELLE(R)
(urofollitropin for injection, purified), REPRONEX(R) (menotropins for
injection, USP), NOVAREL(R) (chorionic gonadotropin for injection, USP) and
ENDOMETRIN in the U.S. to infertility specialists and their patients.
Ferring also offers the Q?CAP(TM), the first and only needle-free
reconstitution device, for use with its fertility treatments.
Ferring's line of orthopaedic and urology products includes EUFLEXXA(R)
(1% sodium hyaluronate) hyaluronic acid for pain from osteoarthritis in the
knee and PROSED(R)/DS for the relief of discomfort of the lower urinary
tract. Other products include: ACTHREL(R) (corticorelin ovine triflutate
for injection) for the differential diagnosis of Cushing's syndrome; and
DESMOPRESSIN ACETATE in injectable and rhinal tube forms for the treatment
of diabetes insipidus and primary nocturnal enuresis.
The Ferring Group specializes in the research, development and
commercialization of compounds in general and pediatric endocrinology,
urology, gastroenterology, obstetrics/ gynecology and infertility. For more
information, call 888-337-7464 or visit www.ferringusa.com or
Contact Andrea Preston for full prescribing information for ENDOMETRIN.
SOURCE Ferring Pharmaceuticals