Reportlinker Adds Nanobiotechnologies- Applications, Markets and Companies

NEW YORK, Sept. 7 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Nanobiotechnologies- applications, markets and companies

http://www.reportlinker.com/p0203545/Nanobiotechnologies--applications-markets-and-companies.html

Summary

Nanotechnology is the creation and utilization of materials, devices, and systems through the control of matter on the nanometer-length scale (a nanometer is one billionth of a meter. Nanobiotechnology, an integration of physical sciences, molecular engineering, biology, chemistry and biotechnology holds considerable promise of advances in pharmaceuticals and healthcare. The report starts with an introduction to various techniques and materials that are relevant to nanobiotechnology. It includes some of the physical forms of energy such as nanolasers. Some of the technologies are scaling down such as microfluidics to nanofluidic biochips and others are constructions from bottom up. Application in life sciences research, particularly at the cell level sets the stage for role of nanobiotechnology in healthcare in subsequent chapters.

Some of the earliest applications are in molecular diagnostics. Nanoparticles, particularly quantum dots, are playing important roles. In vitro diagnostics, does not have any of the safety concerns associated with the fate of nanoparticles introduced into the human body. Numerous nanodevices and nanosystems for sequencing single molecules of DNA are feasible. Various nanodiagnostics that have been reviewed will improve the sensitivity and extend the present limits of molecular diagnostics.

An increasing use of nanobiotechnology by the pharmaceutical and biotechnology industries is anticipated. Nanotechnology will be applied at all stages of drug development - from formulations for optimal delivery to diagnostic applications in clinical trials. Many of the assays based on nanobiotechnology will enable high-throughput screening. Some of nanostructures such as fullerenes are themselves drug candidates as they allow precise grafting of active chemical groups in three-dimensional orientations. The most important pharmaceutical applications are in drug delivery. Apart from offering a solution to solubility problems, nanobiotechnology provides and intracellular delivery possibilities. Skin penetration is improved in transdermal drug delivery. A particularly effective application is as nonviral gene therapy vectors. Nanotechnology has the potential to provide controlled release devices with autonomous operation guided by the needs.

Nanomedicine is now within the realm of reality starting with nanodiagnostics and drug delivery facilitated by nanobiotechnology. Miniature devices such as nanorobots could carry out integrated diagnosis and therapy by refined and minimally invasive procedures, nanosurgery, as an alternative to crude surgery. Nanotechnology will markedly improve the implants and tissue engineering approaches as well.

There is some concern about the safety of nanoparticles introduced in the human body and released into the environment. Research is underway to address these issues. As yet there are no FDA directives to regulate nanobiotechnology but as products are ready to enter market, these are expected to be in place.

Future nanobiotechnology markets are calculated on the basis of the background markets in the areas of application and the share of this market by new technologies and state of development at any given year in the future. This is based on a comprehensive and thorough review of the current status of nanobiotechnology, research work in progress and anticipated progress. There is definite indication of large growth of the market but it will be uneven and cannot be plotted as a steady growth curve. Marketing estimates are given according to areas of application, technologies and geographical distribution starting with 2009. The largest expansion is expected between the years 2014 and 2019.

Profiles of 243 companies, out of over 500 involved in this area, are included in the last chapter along with their 188 collaborations.The report is supplemented with 41 Tables, 21 figures and 700 references to the literature.

TABLE OF CONTENTS

0.Executive Summary19

1.Basics of Nanobiotechnology21

Introduction21

Classification of nanobiotechnologies22

Top-down and bottom-up approaches23

Landmarks in the evolution of nanobiotechnology23

Relation of nanobiotechnology to healthcare24

2.Technologies27

Introduction27

Micro- and nano-electromechanical systems27

BioMEMS27

Microarrays and nanoarrays28

Dip Pen Nanolithography for nanoarrays28

Protein nanoarrays29

Microfluidics and nanofluidics30

Nanotechnology on a chip30

Microfluidic chips for nanoliter volumes31

Nanogen's NanoChip32

Use of nanotechnology in microfluidics33

Construction of nanofluidic channels33

Nanoscale flow visualization34

Moving (levitation) of nanofluidic drops with physical forces34

Electrochemical nanofluid injection34

Nanofluidics on nanopatterned surfaces35

Nano-interface in a microfluidic chip35

Nanofluidic channels for study of DNA35

Visualization and manipulation on nanoscale36

4Pi microscope36

Atomic force microscopy36

Basic AFM operation36

Advantages of AFM36

Force sensing Integrated Readout and Active Tip37

Cantilever technology37

CytoViva® Microscope System39

Fluorescence Resonance Energy Transfer39

Magnetic resonance force microscopy and nanoscale MRI39

Multiple single-molecule fluorescence microscopy40

Near-field scanning optical microscopy40

Nano-sized light source for single cell endoscopy40

Nanoparticle characterization by Halo? LM10 technology41

Nanoscale scanning electron microscopy42

Use of SEM to reconstruct 3D tissue nanostructure42

Optical Imaging with a Silver Superlens42

Photoactivated localization microscopy43

Scanning probe microscopy43

Partial wave spectroscopy44

Ultra-nanocrystalline diamond44

Visualizing atoms with high-resolution transmission electron microscopy45

Companies that provide microscopes for nanobiotechnology45

Surface plasmon resonance46

Nanoparticles46

Types of nanoparticles47

Fluorescent nanoparticles47

Gold nanoparticles47

Lipoparticles47

Paramagnetic and superparamagnetic nanoparticles48

Quantum dots48

Silica nanoparticles50

Assembly of nanoparticles into micelles50

Biomedical applications of self-assembly of nanoparticles50

Production techniques for nanoparticles51

Nanostructures52

Bacterial structures relevant to nanobiotechnology52

Bacterial spores52

Nanostructures based on bacterial cell surface layers53

Bacterial magnetic particles53

Cubosomes54

Dendrimers54

Properties55

Applications55

DNA-nanoparticle conjugates56

DNA octahedron56

Potential applications57

Fullerenes57

Nanoshells57

Nanotubes58

Carbon nanotubes58

Carbon nanotubes and DNA59

Applications of nanotubes59

NanoBuds60

Nanowires60

Nanostamping61

Nanoneedles61

Nanopores61

Nanoporous silica aerogel62

Nanostructured silicon63

Networks of gold nanoparticles and bacteriophage63

Polymer nanofibers63

Protein-nanoparticle combination64

Nanomaterials for biolabeling64

DNA Nanotags66

Fluorescent lanthanide nanorods66

Magnetic nanotags66

Molecular computational identification67

Nanophosphor labels67

Organic nanoparticles as biolabels68

Quantum dots as labels68

SERS nanotags69

Silica nanoparticles for labeling antibodies69

Silver nanoparticle labels69

Companies providing services and products for nanobiotechnology70

3.Applications in Life Sciences71

Introduction71

Nanotechnology and biology71

NanoSystems Biology71

Nanobiology and the cell72

Biosensing of cellular responses73

Control of T cell signaling activity73

Measuring mass of single cells74

Nanostructures involved in endocytosis74

Nanotechnology-based live-cell single molecule assays74

Quantum dots for cell labeling75

Quantum dots for study of apoptosis75

Single cell injection by nanolasers75

Study of complex biological systems76

Molecular motors76

Nanomotor made of nucleic acids78

phi29 DNA packaging nanomotor78

Light-activated ion channel molecular machines79

Application of AFM for biomolecular imaging79

Future insights into biomolecular processes by AFM80

4Pi microscopy to study DNA double-strand breaks80

Multi-isotope imaging mass spectrometry81

Applications of biomolecular computing in life sciences81

Molecular electronics82

Microbial nanomaterials82

Use of bacteria to construct nanomachines82

Bacteriophage nanoshells83

Natural nanocomposites83

Nanotechnology in biological research83

Nanoparticles for biological research84

Disguising quantum dots as proteins for cell entry84

Molecular biology and nanotechnology85

Structural DNA nanotechnology85

Reversibly binding of gold nanospheres to DNA strands86

RNA nanotechnology87

Genetically engineered proteins for nanobiotechnology87

Single molecule studies88

Optical trapping and single-molecule fluorescence88

3D single-molecular imaging by coherent X-ray diffraction imaging88

Studying the molecular mechanisms of enzymes88

Nanochemistry89

Nanoscale pH Meter89

Application of nanolasers in life sciences89

Nanomanipulation90

Nanomanipulation by combination of AFM and other devices90

Surgery on living cells using AFM with nanoneedles91

Optoelectronic tweezers91

Optical manipulation of nanoparticles92

Manipulation of DNA sequence by use of nanoparticles as laser light antennas92

Nanomanipulation of single molecule92

Fluorescence-force spectroscopy93

Nanomanipulation for study of mechanism of anticancer drugs93

Nanotechnology in genomic research93

Nanotechnology for separation of DNA fragments93

Nanostructured devices for controlled gene expression94

Nanotechnology-based DNA sequencing94

Single-molecule detection of DNA hybridization94

Role of nanobiotechnology in identifying single nucleotide polymorphisms95

Nanobiotechnology for study of mitochondria95

Nanomaterials for the study of mitochondria95

Study of mitochondria with nanolaser spectroscopy96

Role of nanotechnology in proteomics research96

Study of proteins by atomic force microscopy96

Single cell nanoprobe for studying gene expression of individual cells97

Nanoproteomics97

Dynamic reassembly of peptides97

High-field asymmetric waveform ion mobility mass spectrometry98

Multi Photon Detection98

Nanoflow liquid chromatography98

Nanoproteomics for study of misfolded proteins99

Nanotube electronic biosensor for proteomics99

Nanometer photomasks from bacterial protein99

Protein nanocrystallography100

QD-protein bioconjugate nanoassembly100

Proteomics at single molecule level101

Study of protein synthesis and single-molecule processes101

Protein expression in individual cells at the single molecule level102

Single-molecule mass spectrometry using nanotechnology102

Biochips for nanoscale proteomics103

Protein biochips based on fluorescence planar wave guide technology103

Nanofilter array chip103

Role of nanotechnology in study of membrane proteins104

Nanoparticles for study of membrane proteins104

Study of single protein interaction with cell membrane104

Quantum dots to label cell surface proteins104

Study of single membrane proteins at subnanometer resolution105

Nanoparticle-protein interactions105

Protein engineering on nanoscale105

Nanowires for protein engineering105

A nanoscale mechanism for protein engineering106

Role of nanoparticles in self-assembly of proteins106

Role of nanotechnology in peptide engineering106

Manipulating redox systems for nanotechnology.107

Self-assembling peptide scaffold technology for 3-D cell culture107

Nanobiotechnology and ion channels108

Aquaporin water channels108

Role of nanobiotechnology in engineering ion channels109

Application of nanobiotechnology in molecular electronics110

Nanotechnology and bioinformatics110

3D nano-map of synapse111

Companies providing nanotechnology for life sciences research111

4.Nanomolecular Diagnostics113

Introduction113

Nanodiagnostics113

Rationale of nanotechnology for molecular diagnostics114

Nanoarrays for molecular diagnostics115

NanoPro™ System115

Nanofluidic/nanoarray devices to detect a single molecule of DNA115

Self-assembling protein nanoarrays116

Fullerene photodetectors for chemiluminescence detection on microfluidic chip116

Nanofountain AFM probe116

AFM for immobilization of biomolecules in high-density microarrays117

Protein microarray for detection of molecules with nanoparticles117

Protein nanobiochip117

Nanoparticles for molecular diagnostics118

Gold nanoparticles118

Quantum dots for molecular diagnostics118

Quantum dots for detection of pathogenic microorganisms119

Bioconjugated QDs for multiplexed profiling of biomarkers119

Imaging of living tissue with QDs120

Use of nanocrystals in immunohistochemistry120

Magnetic nanoparticles121

Ferrofluids121

Magnetic nanoparticles for bioscreening121

Monitoring of implanted NSCs labeled with nanoparticles121

Perfluorocarbon nanoparticles to track therapeutic cells in vivo121

Superparamagnetic nanoparticles for cell tracking122

Superparamagnetic iron oxide nanoparticles for calcium sensing122

Magnetic nanoparticles for labeling molecules122

Super conducting quantum interference device123

Study of living cells by superparamagnetic nanoparticles123

Imaging applications of nanoparticles123

Dendritic nanoprobes for imaging of angiogenesis124

Gadolinium-loaded dendrimer nanoparticles for tumor-specific MRI124

Gadonanotubes for MRI125

Gold nanorods and nanoparticles as imaging agents125

In vivo imaging using nanoparticles125

Manganese oxide nanoparticles as contrast agent for brain MRI126

Nanoparticles vs microparticles for cellular imaging126

Nanoparticles as contrast agent for MRI126

Optical molecular imaging using targeted magnetic nanoprobes127

QDs for biological imaging127

Superparamagnetic iron nanoparticles combined with MRI128

Concluding remarks and future prospects of nanoparticles for imaging128

Study of chromosomes by atomic force microscopy128

Applications of nanopore technology for molecular diagnostics129

Nanopore technology for detection of single DNA molecules129

Nanocytometry130

Simultaneous detection of DNA and proteins130

DNA-protein and -nanoparticle conjugates130

Resonance Light Scattering technology131

DNA nanomachines for molecular diagnostics132

Nanobarcodes technology132

Nanobarcode particle technology for SNP genotyping132

Qdot nanobarcode for multiplexed gene expression profiling133

Biobarcode assay for proteins133

Single-molecule barcoding system for DNA analysis135

Nanoparticle-based colorimetric DNA detection method135

SNP genotyping with gold nanoparticle probes136

Nanoparticle-based Up-converting Phosphor Technology136

Surface-Enhanced Resonant Raman Spectroscopy136

Near-infrared (NIR)-emissive polymersomes137

Nanobiotechnology for detection of proteins138

Captamers with proximity extension assay for proteins138

Nanobiosensors138

Cantilevers as biosensors for molecular diagnostics138

Advantages of cantilever technology for molecular recognition139

Antibody-coated nanocantilevers for detection of microorganisms140

Cantilevers for direct detection of active genes140

Portable nanocantilever system for diagnosis141

Carbon nanotube biosensors141

Carbon nanotube sensors coated with ssDNA and electronic readout141

Carbon nanotubes sensors wrapped with DNA and optical detection142

FRET-based DNA nanosensor142

Ion Channel Switch biosensor technology143

Electronic nanobiosensors143

Electrochemical nanobiosensor144

Metallic nanobiosensors144

Quartz nanobalance biosensor144

Viral nanosensor145

PEBBLE nanosensors145

Detection of cocaine molecules by nanoparticle-labeled aptasensors145

Nanosensors for glucose monitoring145

Microneedle-mounted biosensor146

Optical biosensors146

Laser nanosensors146

Nanoshell biosensors147

Plasmonics and SERS nanoprobes147

Novel optical mRNA biosensor148

Optonanogen biosensor148

Surface plasmon resonance technology149

Surface Enhanced Micro-optical Fluidic Systems150

Nanoparticle-enhanced sensitivity of fluorescence-based biosensors150

Nanowire biosensors150

Nanowire biosensors for detection of single viruses151

Nanowires for detection of genetic disorders151

Nanowires biosensor for detecting biowarfare agents152

Concluding remarks and future prospects of nanowire biosensors152

Nanoscale erasable biodetectors152

Future issues in the development of nanobiosensors153

Applications of nanodiagnostics154

Nanotechnology for detection of biomarkers154

Nanotechnology for genotyping of single-nucleotide polymorphisms155

Nanoparticles for detecting SNPs155

Nanopores for detecting SNPs155

Nanobiotechnologies for single molecule detection156

Protease-activated quantum dot probes157

Labeling of MSCs with QDs157

Nanotechnology for detection of cancer157

Dendrimers for sensing cancer cell apoptosis158

Detection of circulating cancer cells158

Differentiation between normal and cancer cells by nanosensors158

Gold nanoparticles for cancer diagnosis158

Gold nanorods for detection of metastatic tumor cells159

Implanted magnetic sensing for cancer159

Nanoatomic tubes for detection of cancer proteins160

Nanobiochip sensor technique for analysis of oral cancer biomarkers160

Nanodots for tracking apoptosis in cancer161

Nanolaser spectroscopy for detection of cancer in single cells161

Nanoparticles designed for dual-mode imaging of cancer161

Nanotechnology-based single molecule assays for cancer162

QDs for detection of tumors162

QD-based test for DNA methylation163

Nanotechnology for point-of-care diagnostics163

Nanotechnology-based biochips for POC diagnosis164

Nanoprobes for POC diagnosis164

Carbon nanotube transistors for genetic screening164

POC monitoring of vital signs with nanobiosensors165

Detection of viruses165

Cantilever beams for detection of single virus particles165

Carbon nanotubes as biosensors for viruses166

Electric fields for accelerating detection of viruses166

QD fluorescent probes for detection of respiratory viral infections166

Verigene SP Respiratory Virus Assay167

Surface enhanced Raman scattering for detection of viruses168

Detection of bacteria168

QDs for detection of bacterial infections169

SEnsing of Phage-Triggered Ion Cascade for detection of bacteria169

Nanodiagnostics for the battle field and biodefense169

An integrated nanobiosensor170

Nanodiagnostics for integrating diagnostics with therapeutics170

Companies involved in nanomolecular diagnostics171

Concluding remarks about nanodiagnostics173

Future prospects of nanodiagnostics174

5.Nanobiotechnology in Drug Discovery & Development177

Introduction177

Nanobiotechnology for drug discovery177

Nanofluidic devices for drug discovery178

Gold nanoparticles for drug discovery179

Tracking drug molecules in cells179

SPR with colloidal gold particles179

Use of quantum dots for drug discovery179

Advantages of the use of QDs for drug discovery179

Drawbacks of the use of QDs for drug discovery180

Quantum dot for imaging drug receptors in the brain181

Ligand-conjugated nanocrystals181

Lipoparticles for drug discovery181

Biosensor for drug discovery with Lipoparticles181

Magnetic nanoparticles assays182

Micelles for drug discovery182

Nanolasers for drug discovery182

Analysis of small molecule-protein interactions by nanowire biosensors183

Cells targeting by nanoparticles with attached small molecules183

Role of AFM for study of biomolecular interactions for drug discovery183

Nanoscale devices for drug discovery184

Nanotechnology enables drug design at cellular level185

Nanobiotechnology-based drug development185

Dendrimers as drugs185

Fullerenes as drug candidates186

Nanobodies187

Role of nanobiotechnology in the future of drug discovery188

Companies using nanobiotechnology for drug discovery188

6.Nanobiotechnology in Drug Delivery191

Introduction191

Micronization versus nanonization for drug delivery191

Nanoscale devices delivery of therapeutics191

Nanobiotechnology solutions to the problems of drug delivery191

Nanosuspension formulations192

Nanotechnology for solubilization of water-insoluble drugs193

Improved absorption of drugs in nanoparticulate form193

Interaction of nanoparticles with human blood193

Ideal properties of material for drug delivery193

Nanomaterials and nanobiotechnologies used for drug delivery194

Viruses as nanomaterials for drug delivery195

Bacteria-mediated delivery of nanoparticles and drugs into cells195

Nanoparticle-based drug delivery196

Calcium phosphate nanoparticles196

Cationic nanoparticles197

Ceramic nanoparticles197

Cyclodextrin nanoparticles for drug delivery197

Dendrimers for drug delivery198

DNA-assembled dendrimers for drug delivery198

Fulleres for drug delivery199

Amphiphilic fullerene derivatives199

Fullerene conjugate for intracellular delivery of peptides199

Gold nanoparticles as drug carriers199

Layered double hydroxide nanoparticles199

Nanocomposite membranes for magnetically triggered drug delivery200

Nanocrystals200

Nanocrystalline silver200

Elan's NanoCrystal technology201

Eurand's Biorise system201

Nanodiamonds202

Polymer nanoparticles203

Biodegradable PEG nanoparticles for penetrating the mucus barrier203

PLGA-based nanodelivery technologies203

Polymeric micelles204

Chitosan nanoparticles204

QDs for drug delivery205

Special procedures in nanoparticle-based drug delivery205

Coated nanoparticles for penetrating cell membranes without damage205

Drug delivery using "Particle Replication in Nonwetting Templates"206

Encapsulating water-insoluble drugs in nanoparticles206

Filomicelles vs spherical nanoparticles for drug delivery207

Flash NanoPrecipitation207

Magnetic nanoparticles for drug delivery208

Nanoparticles bound together in spherical shapes208

Perfluorocarbon nanoparticles for imaging and targeted drug-delivery209

Prolonging circulation of nanoparticles by attachment to RBCs209

Self-assembling nanoparticles for intracellular drug delivery210

Trojan nanoparticles210

Therapeutic protein delivery from nanoparticle-protein complexes210

Liposomes211

Basics of liposomes211

Stabilization of phospholipid liposomes using nanoparticles211

Lipid nanoparticles212

Polymerized Liposomal Nanoparticle212

Applications of lipid nanoparticles213

Limitations of liposomes for drug delivery213

Lipid nanocapsules213

Lipid emulsions with nanoparticles214

Nanostructured organogels215

Liposomes incorporating fullerenes215

Arsonoliposomes215

Liposome-nanoparticle hybrids215

Nanogels216

Nanogel-liposome combination216

Nanospheres217

Nanosphere protein cages217

Nanovesicle technology for delivery of peptides217

Nanotubes217

Carbon nanotubes for drug delivery218

Lipid-protein nanotubes for drug delivery218

Halloysite nanotubes for drug delivery219

Nanocochleates220

Nanobiotechnology and drug delivery devices221

Coating of implants by ultrafine layers of polymers221

Nano-encapsulation221

Polymer nanocontainers222

Nanotechnology-based device for insulin delivery222

Mirocontainer delivery systems for cell therapy223

Nanoporous materials for drug delivery devices223

Nanopore membrane in implantable titanium drug delivery device223

Measuring the permeability of nanomembranes224

Nanovalves for drug delivery224

Nanochips for drug delivery224

Nanobiotechnology for vaccine delivery225

Bacterial spores for delivery of vaccines225

Nanoparticles for DNA vaccines225

Nanospheres for controlled release of viral antigens225

Proteosomes™ as vaccine delivery vehicles226

Targeted Synthetic Vaccine Particle (tSVP™) technology226

Nanobiotechnology for antisense drug delivery226

Antisense nanoparticles226

Dendrimers for antisense drug delivery227

Polymer nanoparticles for antisense delivery system227

Nanoparticle-mediated siRNA delivery228

Chitosan-coated nanoparticles for siRNA delivery228

Delivery of gold nanorod-siRNA nanoplex to dopaminergic neurons228

Polymer-based nanoparticles for siRNA delivery228

Polyethylenimine nanoparticles for siRNA delivery228

siRNA-PEG nanoparticle-based delivery229

Polycation-based nanoparticles for siRNA delivery229

Calando's technology for targeted delivery of anticancer siRNA230

Quantum dots to monitor RNAi delivery230

Nanobiotechnology for gene therapy231

Nanoparticle-mediated gene therapy231

Calcium phosphate nanoparticles as nonviral vectors232

Carbonate apatite nanoparticles for gene delivery232

Gelatin nanoparticles for gene delivery233

Immunolipoplex for delivery of p53 gene233

Lipid nanoparticles for targeted delivery of nucleic acids234

Nanoparticles for imaging and intracellular delivery of nucleic acids234

Nanoparticles as nonviral vectors for CNS gene therapy234

Nanoparticles linked to viral vectors for photothermal therapy235

Nanoparticles for p53 gene therapy of cancer235

Nanoparticles with virus-like function as gene therapy vectors236

Silica nanoparticles for gene delivery236

Targeted nanoparticle-DNA delivery to the cardiovascular system236

Dendrimers for gene transfer237

DNA-PEG complexes as nanoparticles238

Compacted DNA nanoparticles238

Cochleate-mediated DNA delivery238

Nanorod gene therapy239

Nanodel? gene vector239

Nanomagnets for targeted cell-based cancer gene therapy240

NanoNeedles for delivery of genetic material into cells240

Nanomachines for gene delivery240

Application of pulsed magnetic field and superparamagnetic nanoparticles240

Nanocomposites for gene therapy241

Nonionic polymeric micelles for oral gene delivery241

Nanocarriers for simultaneous delivery of anticancer drugs and DNA241

Delivery of siRNA by nanosize liposomes242

Nanobiotechnology-based drug delivery in cancer242

Nanoparticle formulations for drug delivery in cancer244

Anticancer drug particles incorporated in liposomes244

Encapsulating drugs in hydrogel nanoparticles245

Exosomes246

Folate-linked nanoparticles246

Iron oxide nanoparticles247

Lipid based nanocarriers247

Micelles for drug delivery in cancer247

Minicells for targeted delivery of nanoscale anticancer therapeutics249

Nanomaterials for delivery of poorly soluble anticancer drugs249

Nanoparticle formulation for enhancing anticancer efficacy of cisplatin249

Nanoparticle formulations of paclitaxel250

Nanoparticles containing albumin and antisense oligonucleotides251

Non-aggregating nanoparticles251

Pegylated nanoliposomal formulation251

Poly-2-hydroxyethyl methacrylate nanoparticles252

Polypeptide-doxorubicin conjugated nanoparticles252

Protosphere nanoparticle technology252

Zinc oxide nanoparticles for drug delivery in cancer253

Nanoparticles for targeted delivery of anticancer therapeutics253

Antiangiogenic therapy using nanoparticles254

Canine parvovirus as a nanocontainer for targeted drug delivery254

Carbon magnetic nanoparticles for targeted drug delivery in cancer255

Carbon nanotubes for targeted drug delivery to cancer cells255

Cyclosert system for targeted delivery of anticancer therapeutics256

DNA aptamer-micelle for targeted drug delivery in cancer256

DNA aptamer-micelle for targeted drug delivery in cancer256

Fullerenes for enhancing tumor targeting by antibodies257

Gold nanoparticles for targeted drug delivery in cancer257

Lipoprotein nanoparticles targeted to cancer-associated receptors259

Magnetic nanoparticles for remote-controlled drug delivery to tumors259

Nanobees for targeted delivery of cytolytic peptide melittin259

Nanocell for targeted drug delivery to tumor260

Nanodiamonds for local delivery of chemotherapy at site of cancer261

Nanoimmunoliposome-based system for targeted delivery of siRNA261

Nanoparticle-mediated targeting of MAPK signaling pathway262

Nanoparticles for targeted antisense therapy of cancer262

Nanoparticles for delivery of suicide DNA to prostate tumors262

Nanostructured hyaluronic acid for targeted drug delivery in cancer262

Polymer nanoparticles for targeted drug delivery in cancer263

Polymersomes for targeted cancer drug delivery264

Quantum dots and quantum rods for targeted drug delivery in cancer264

Remote controlled drug delivery from magnetic nanocrystals265

Targeted delivery of nanoparticulate drugs into lymphatic system265

Targeted drug delivery with nanoparticle-aptamer bioconjugates265

Dendrimers for anticancer drug delivery266

Application of dendrimers in boron neutron capture therapy267

Application of dendrimers in photodynamic therapy267

Dendrimer-based synthetic vector for targeted cancer gene therapy268

Poly-L-lysine dendrimer as antiangiogenetic agent268

Devices for nanotechnology-based cancer therapy269

Convection-enhanced delivery with nanoliposomal CPT-11269

Nanocomposite devices269

Nanoengineered silicon for brachytherapy269

Nanoparticles combined with physical agents for tumor ablation270

Boron neutron capture therapy using nanoparticles270

Laser-induced cancer destruction using nanoparticles270

Photodynamic therapy of cancer using nanoparticles271

Thermal ablation using nanoparticles272

Thermosensitive affibody-conjugated liposomes273

Ultrasound radiation of tumors combined with nanoparticles273

RNA nanotechnology for delivery of cancer therapeutics273

Delivery of siRNAs for cancer274

Nanocarriers for simultaneous delivery of multiple anticancer agents274

Nanotechnology-based drug delivery to the CNS274

Nanoencapsulation for delivery of vitamin E for CNS disorders274

Nanoparticle technology for drug delivery across BBB275

Delivery across BBB using NanoDel? technology276

NanoMed technology to mask BBB-limiting characteristics of drugs276

Nanovesicles for transport across BBB276

Nanotechnology-based drug delivery to brain tumors277

Multifunctional nanoparticles for treating brain tumors277

Nanoparticles for delivery of drugs to brain tumors across BBB277

Nanoparticle delivery across the BBB for imaging and therapy of brain tumors278

Intravenous gene delivery with nanoparticles into brain tumors279

PLA nanoparticles for controlled delivery of BCNU to brain tumors279

Nanotechnology-based devices and implants for CNS279

Nanoparticle-based drug delivery to the inner ear280

Nanobiotechnology in cardiovascular drug delivery280

Liposomal nanodevices for targeted cardiovascular drug delivery280

Drugs encapsulated in biodegradable nanoparticles280

Controlled delivery of nanoparticles to injured vasculature281

Nanotechnology-based drug-eluting stents281

Drugs encapsulated in biodegradable nanoparticles281

Magnetic nanoparticle-coated DES282

Nanopores to enhance compatibility of drug-eluting stents282

Low molecular weight heparin-loaded polymeric nanoparticles282

Injectable peptide nanofibers for myocardial ischemia283

Nanotechnology approach to the vulnerable plaque as cause of cardiac arrest283

Nanobiotechnology-based transdermal drug delivery283

Delivery of nanostructured drugs from transdermal patches284

Ethosomes for transdermal drug delivery284

NanoCyte transdermal drug delivery system285

Nanoparticles for targeted therapeutic delivery to the liver286

Nanoparticles for pulmonary drug delivery286

Systemic drug delivery via pulmonary route286

Nanoparticle drug delivery for effects on the respiratory system286

Fate and toxicology of nanoparticles delivered to the lungs287

Nanoparticle drug formulations for spray inhalation287

Inhalation of glucose-sensitive nanoparticle for regulated release of insulin287

Pulmonary drug delivery by surface acoustic wave technology288

In vivo lung gene transfer using compacted DNA nanoparticles288

Nasal drug delivery using nanoparticles288

Mucosal drug delivery with nanoparticles289

Companies involved in nanobiotechnology-based drug delivery289

Future prospects of nanotechnology-based drug delivery293

Nanomolecular valves for controlled drug release294

Nanosponge for drug delivery294

Nanomotors for drug delivery294

7.Clinical Applications of Nanobiotechnology295

Introduction295

Nanomedicine295

Clinical nanodiagnostics296

Nano-endoscopy296

Application of nanotechnology in radiology297

High-resolution ultrasound imaging using nanoparticles297

Nanobiotechnology combined with stem cell-based therapies298

Nanobiotechnology in tissue engineering299

3D nanofilament-based scaffolds299

Electrospinning technology for bionanofabrication300

Nanomaterials for tissue engineering300

Carbon nanotubes for artificial muscles301

Nanofibers for tissue engineering of skeletal muscle301

Nanomaterials for combining tissue engineering and drug delivery301

Nanobiotechnology for organ replacement and assisted function302

Exosomes for drug-free organ transplants302

Nanobiotechnology and organ-assisting devices303

Nanotechnology-based human nephron filter for renal failure303

Blood-compatible membranes for renal dialysis304

Nanosurgery304

Miniaturization in surgery304

Nanotechnology for hemostasis during surgery304

Minimally invasive surgery using catheters305

Nanorobotics305

Nanoscale laser surgery306

Nanooncology307

Nanobiotechnology for early detection of cancer to improve treatment307

Impact of nanotechnology-based imaging in management of cancer307

Nanoparticle-MRI for tracking dendritic cells in cancer therapy308

Nanoparticle-CT scan308

QDs aid lymph node mapping in cancer308

Nanosensor device as an aid to cancer surgery309

Role of nanoparticle-based imaging in oncology clinical trials309

Nanoparticle-based anticancer drug delivery to overcome MDR309

Nanoparticle-based management of cancer metastases310

Nanoshells for thermal ablation in cancer310

Nanobody-based cancer therapy311

Nanoparticles for targeting tumors312

Nanocarriers with TGF-? inhibitors for targeting cancer312

Nanoshell-based cancer therapy313

Nanobomb for cancer313

Combination of diagnostics and therapeutics for cancer314

Biomimetic nanoparticles targeted to tumors314

Dendrimer nanoparticles for targeting and imaging tumors314

Gold nanoparticle plus bombesin for imaging and therapy of cancer314

Gold nanorods for diagnosis plus photothermal therapy of cancer315

Magnetic nanoparticles for imaging as well as therapy of cancer315

Nanobialys for combining MRI with delivery of anticancer agents316

Nanoparticles, MRI and thermal ablation of tumors316

pHLIP nanotechnology for detection and targeted therapy of cancer316

QD conjugates combine cancer imaging, therapy and sensing317

Radiolabeled carbon nanotubes for tumor imaging and targeting317

Self-assembling nanoparticles for imaging and therapy of cancer317

Targeted therapy with magnetic nanomaterials guided by antibodies318

Ultrasonic tumor imaging and targeted chemotherapy by nanobubbles318

A cancer killing device based on nanotechnology318

Nanoparticles for protection against adverse effects of radiation therapy319

Fullerenes for protection against chemotherapy-induced cardiotoxicity319

Role of nanobiotechnology in personalized management of cancer319

Concluding remarks on nanooncology320

Nanoneurology320

Nanobiotechnology for study of the nervous system321

Nanowires for monitoring brain activity321

Nanoparticles and MRI for macrophage tracking in the CNS321

Nanoparticles for tracking stem cells for therapy of CNS disorders322

Nanobiotechnology for neurotherapeutics322

Nanowire neuroprosthetics with functional membrane proteins323

Nanoparticles for neuroprotection323

Nanotube-neuron electronic interface323

Nanofibers as an aid to CNS regeneration

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