Telomolecular: Cure for Cancer, Age-Related Diseases Coming Into View

Aug 23, 2006, 01:00 ET from Syndicated News, Inc.

    RANCHO CORDOVA, Calif., Aug. 23 /PRNewswire/ -- Actor Woody Allen once
 said, "I don't want to achieve immortality through my work. I want to
 achieve it through not dying."
     Developments in nanotechnology may soon make Allen's goal possible, as
 biotechnology firms like Telomolecular of Rancho Cordova, Calif., explore
 ways to instill aging tissues and organs with indefinite life.
     Although this sounds like a Jules Verne sci-fi classic, it's for real.
 Nanotechnology firm Telomolecular conducts innovative work in the repair of
 damaged chromosomal telomeres, producing new ways to reverse aging in
 tissues and organs, and new treatments that may one day cure or even
 eradicate cancer. While the elimination of cancer through this technique is
 still a long way off, the hope of treatments for such age-related diseases
 as macular degeneration, osteoporosis, arteriosclerosis, cirrhosis and
 Progeria is right around the corner.
     Simply put, telomeres are protein compounds that act like caps on the
 ends of chromosomes. When a cell divides, the DNA in its chromosomes is
 replicated and passed on to the new cell. Telomeres keep the replication
 process on track. With each replication, however, the telomeres shorten,
 becoming exhausted as a person or organism ages, resulting in cell
 deterioration which is linked to cancer and numerous age-related diseases,
 as well as the general aging process.
     Nanocircles (a nanotechnology developed at Stanford University) and
 vTert (Telomolecular's synthetic enzyme) are capable of repairing damaged
 and shortened telomeres. Researchers at Telomolecular believe they've found
 a way to deliver Nanocircles and vTert to chromosomes in living organisms,
 reversing diseases caused by that damage. The researchers envision the
 ability, eventually, to speed the healing process in humans, preventing or
 even curing cancer.
     "In the laboratory, Telomolecular has regenerated aged tissues that
 remain permanently young and live thousands of times beyond their normal
 replicative life span," said Matthew Sarad, chief executive officer.
 "Duplicated in living animals, this process could cure a variety of
 diseases caused by critical telomere degradation."
     Commercially, telomere therapy has been successfully used to extend the
 life span of cell cultures used in producing pharmaceuticals, growing
 artificial corneas, and accelerating the healing process in skin grafts.
 Sarad predicts cosmetic use of telomere therapy could be available within
 two years, and may not require FDA approval. Other uses of telomere
 therapy, as developed by Telomolecular, include regeneration of damaged
 muscle and bone, accelerating wound healing, treating trauma disorders such
 as strokes, growing replacement organs, and preventing cancer development
 during stem cell therapy.
     Treating macular degeneration, osteoporosis, arteriosclerosis and
 cancer is a lengthy process taking months or years of therapy, often
 unsuccessful. But with advancements in nanotechnology and molecular biology
 such as those achieved at Telomolecular, it's conceivable that treatment of
 these diseases may soon involve only a single, routine outpatient visit to
 a hospital or clinic. And shortly after that, preventative treatments may
 eliminate those diseases completely.
     So, Woody, what might life be like, when we can live forever?
     Jacqueline Bodnar
     (702) 338-3105

SOURCE Syndicated News, Inc.