Global Bone Graft Substitute Industry

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Aug 25, 2016, 04:20 ET

NEW YORK, Aug. 25, 2016 /PRNewswire/ -- This report analyzes the worldwide markets for Bone Graft Substitutes in US$ Million. The US market is further analyzed by the following Segments: Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Bone Grafts, and Synthetic Bone Grafts. The report provides separate comprehensive analytics for the US, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2015 through 2022. Also, a six-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 57 companies including many key and niche players such as -

AlloSource
Baxter International
DePuy Synthes Companies
Exactech, Inc.
Integra LifeSciences Holdings Corporation

Read the full report: http://www.reportlinker.com/p03846693-summary/view-report.html

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1 Disclaimers.............. I-2 Data Interpretation & Reporting Level I-2 Quantitative Techniques & Analytics I-3 Product Definitions and Scope of Study I-3 Demineralized Bone Matrix (DBM) I-3 Bone Morphogenetic Protein (BMP) I-3 Stem-Cell Based Bone Grafts..............I-4 Synthetic Bone Grafts..............I-4

II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW.............. II-1 Bone Grafts - A Prelude..............II-1 Increasing Volume of Orthopedic Procedures Present Promising Prospects for Bone Graft Substitutes (BGS) Market II-2 Growing Clinical Use of Bone Graft Substitutes in Surgical Procedures.............. II-3 Rising Popularity of Synthetic Bone Graft Substitutes II-4 Synthetic Bone Grafts Set to Replace Conventional Autografts and Allografts.............. II-5 DBM: Strong Growth but Tough Competition II-5 Bone Morphogenetic Protein - Safety Concerns Affect Growth Prospects.............. II-6 Stem Cell Based Bone Grafts: Promising Growth Ahead II-6 Developing Markets Hold Lucrative Potential for Bone Graft Substitutes.............. II-7 Autograft: The Gold Standard for Bone Grafting Procedures II-8 Allografts: Leading the Race over Autografts II-8 Advanced Allografts Encroaching into the Use of Autografts in Surgical Procedures..............II-9 Competitive Landscape..............II-9 Bone Graft Products of Select Players II-10

2. GROWTH DRIVERS, ISSUES & TRENDS II-11 A Review of Major Factors Affecting Growth II-11 Aging Population: A Strong Demographic Driver II-11 Table 1: Global Aging Population in Select Regions/Countries: Population of 60+ Individuals in '000s and as a Percentage of Total Population for 2015 & 2050 (includes corresponding Graph/Chart) II-11 Increasing Incidence of Degenerative Intervertebral Disc Diseases.............. II-12 Table 2: % of Women Affected by Osteoporosis (includes corresponding Graph/Chart)..............II-12 Rising Prevalence of Arthritis and Other Orthopedic Disorders II-13 Growing Number of Revision Orthopedic Surgeries II-13 Rise in Spinal Fusions in Private Healthcare II-13 Applications of Bone Graft Substitutes - An Overview II-13 Spine Fusion - The Largest Application Market for Bone Graft Substitutes.............. II-14 Dental Bone Grafting - A High Potential Market II-15 Table 3: Dental Tissue & Bone Regeneration Materials Market (2015): Percentage Share Breakdown by Segment for Allografts, Synthetics, and Xenografts (includes corresponding Graph/Chart)..............II-16 What Drives Physicians' Choice of Bone Grafts? II-16 Challenges for Different Bone Grafts II-17 Patient Safety Emerges as a Top Priority II-17 Growing Volume of Orthopedic Procedures: Opportunity for Bone Graft Substitutes Market..............II-17 Table 4: Fractures by Age Group (2014): Percentage Share Breakdown of Number of Fractures by Age Group II-18

Table 5: Global Orthopedic Market by Segment (2015E): Percentage Breakdown of Value Sales for Extremities, Hips, Knees, Orthobiologics, Spine, Trauma and Others (includes corresponding Graph/Chart)..............II-18

Table 6: Worldwide Orthopedics Medical Technology Market (2015E): Percentage Share Breakdown of Revenues by Company for Johnson & Johnson, Medtronic, Smith & Nephew, Stryker, Zimmer Biomet and Others (includes corresponding Graph/Chart) II-19 Orthobiologics Gain Traction in the Bone Grafts Market II-19 Table 7: Global Orthobiologics Market (2015): Percentage Share Breakdown of Revenues by Product - Allografts, Bone Morphogenetic Proteins (BMP), Demineralized Bone Matrix (DBM), Stem Cells, Synthetic Bone Grafts and Viscosupplements (includes corresponding Graph/Chart) II-21 Increasing Visibility of Orthobiological Products to Spur Grafting Options..............II-21 Spinal Biologics - Bone Graft Substitutes Dominate Market II-22 Technological Advancements Drive Bone Grafts Market II-22 A Glance at Few Recent Innovations/Research Efforts in Bone Grafts.............. II-23 Consortium to Develop SmartBonePep® Bio-hybrid Composite Bone Graft.............. II-23 New Bone Grafting Technique Addresses Shrinkage of Bone due to Tooth Loss.............. II-23 QMUL Researchers Develop Inductigraft Synthetic Bone Grafts II-24 Researchers Develop Aerograft Dental Bone Graft Material for Dental Procedures..............II-24 Foot and Extremity Reconstruction - Promising Market for Bone Grafts.............. II-25 Precision Machined Allografts Gain Surgeon Preference II-25 Unmet Clinical Needs to Foster R&D Engine II-25 Biological Solutions in Sports Medicine - Beyond Bone Grafting II-26 Disease Transmission through Bone Grafts - A Major Safety Concern II-26 Lack of Standards in Bone Graft Substitute Market II-26 Reimbursement Issues Continue to Haunt Bone Grafts Market II-26 Regional Regulations & Religious Beliefs Hamper Bone Graft Substitutes Market.............. II-27 Synthetic Bone Grafts - Solution for Halal Bone Graft Implantation.............. II-27 Bone Glue - A Potential Threat to the Bone Graft Market II-27 Alliances with Organ Procurement Organizations: A Shot in the Arm II-27 Aging Baby Boomers Render a Decreased Donor Pool II-28 Limited Availability of Donor Tissues II-28 Intense Competition from Alternative Tissue Repair Therapies II-28 Substitute Technologies Threaten to Replace Spinal Fusions II-29 Bone Grafts Termed as Tissues Suffer From Inconsistent Patient Outcomes.............. II-29 Innovations in Orthopedic Biomaterials: A Glance at Developments over the Years..............II-29 MPCs: Offer Promising Breakthroughs in Bone Graft Substitute II-29 Peptide Signaling Molecules to the Rescue II-29 Prostaglandin Agonists: Emerging From their Drawbacks II-30 Synthetic Bone Grafts..............II-30 Combination of Bone Marrow and Bone Graft Substitute II-30 Stem Cell Therapy..............II-31 Bone Morphogenetic Proteins..............II-31 GEM OS®1 Shows Promise..............II-31 geneX® Synthetic Bone Graft Substitute II-32 ACCELL Total Bone Matrix..............II-32 New Ways of Fixing Broken Bones II-32 BoneCure Sleeve - Heading Towards the Human Market II-32 Bioactive Glass - Suitable for Weight Bearing Portion II-33 Tissue Recovery & Processing: A Review II-33 Tissue Banks.............. II-33 Tissue Processing..............II-34 Tissue Distribution..............II-34 An Illustration of the Tissue Recovering, Processing, & Distribution Network..............II-35

3. PRODUCT OVERVIEW.............. II-36 Bone Grafts: A Definition..............II-36 Bone Grafts: A Peek into their Mechanism of Action II-36 Types of Bone Grafts..............II-37 Scoring of Osteoconduction, Osteoinduction, and Osteogenesis Properties of Bone Grafts by Type II-37 Autografts.............. II-37 Advantages.............. II-37 Disadvantages.............. II-38 Standard Allografts..............II-38 Advantages.............. II-38 Disadvantages.............. II-39 Machined Bone Allografts..............II-39 Demineralized Bone Matrix..............II-39 Examples of Demineralized Bone Matrix (DBM) II-40 Bone Morphogenetic Proteins (BMPs) II-40 Basic Functions of TGF-Beta..............II-40 Infuse®.............. II-40 OP-1.............. II-41 Synthetic Bone Grafts..............II-41 Examples of Synthetic Bone Grafts II-41 Collagen-based Matrices..............II-42 Ceramic: A Material of Choice..............II-42 Hydroxyapatite: A Major Calcium Phosphate Based Ceramic II-43 Calcium Sulfate.............. II-43 Polymer Based Bone Grafts..............II-43 Coral: A Valuable Synthetic Graft Material II-43 Application of Bone Grafts..............II-43 Spinal Fusion.............. II-43 Trauma & Reconstructive Surgeries II-44 Trauma.............. II-44 Reconstructive Surgeries..............II-44 Joint Revision Arthroplasty II-44 Oral, Periodontal, and Cranio-Maxillofacial II-44

4. REGULATORY ENVIRONMENT & REIMBURSEMENTS II-45 Regulatory Issues.............. II-45 FDA Classification of Bone Products II-45 Human Cells, Tissues and Cellular and Tissue-Based Products (HCT/Ps).............. II-45 National Organ Transplant Act (NOTA) II-46 Good Tissue Practices..............II-46 Tissue Banking Regulation..............II-46 FDA Regulations on Xenograft..............II-46 DBM-based Products in US..............II-47 Synthetic Bone Graft Substitutes II-47

5. PRODUCT INNOVATIONS/INTRODUCTIONS II-48 Citagenix Launches PentOS OI™ Putty Bone Graft Substitute II-48 AlloSource® Introduces ProChondrix® Cartilage Restoration Matrix II-48 AlloSource Wins Patent for AlloStem® Cellular Bone Allograft II-48 OrthoSera Introduces Bone Albumin Bone Substitute II-48 AmnioLife to Introduce Oncor™ DBM II-48 DePuy Synthes Launches VIVIGEN® Cellular Bone Matrix II-48 Stryker Launches BIO4™ Bone Matrix II-49 BONESUPPORT™ Gains Approval for Marketing CERAMENT™ in India II-49 DePuy Synthes Launches ViviGen™ Cellular Bone Matrix II-49 RTI Surgical Launches Precision Allograft Cartilage Kit II-49 RTI Surgical Announces Human Implantation of map3® Cellular Allogeneic Bone Graft Strips..............II-49 Zimmer Spine Introduces Puros Demineralized Bone Matrix (DBM) Range.............. II-49 RTI Surgical Introduces New Natural Bone Grafting Solutions II-50 Nobel Biocare Introduces creos™ Allograft Regenerative Solution II-50 DePuy Synthes Spine Introduces CONFORM SHEET™ in the US II-50

6. RECENT INDUSTRY ACTIVITY..............II-51 AllowSource Receives Patent for ProChondrix® Cartilage Restoration Matrix.............. II-51 MiMedx Group Takes Over Stability Biologics II-51 Wright Medical Merges with Tornier II-51 AlloSource Wins Patent for Acellular Human Dermal Matrix II-51 AlloSource Bags Patent for AlloStem® Cellular Bone Allograft II-51 Medtronic Gains FDA Approval for Infuse® Bone Graft for New Spine Surgery Indications..............II-52 Bioventus Takes Over BioStructures LLC II-52 NuVasive Gains FDA Approval for Cervical Corpectomy Cage II-52 BioMimetic Wins FDA (PMA) Approval for AUGMENT® Bone Graft II-52 Zimmer Merges with Biomet to Create Zimmer Biomet Holdings II-52 NovaBone Gains FDA Approval for NovaBone MacroFORM MIS Delivery System™.............. II-52 Osiris Therapeutics and Stryker in Exclusive Partnership II-52 Wright Medical Gains FDA (PMA) Approval for Augment® Bone Graft II-53 Zimmer Takes Over ETEX Holdings..............II-53 Wright Medical Acquires BioMimetic II-53 RTI Biologics Acquires Pioneer® Surgical Technology II-53

7. FOCUS ON SELECT PLAYERS..............II-54 AlloSource (USA).............. II-54 Baxter International, Inc. (USA) II-54 DePuy Synthes Companies (USA)..............II-54 Exactech, Inc. (USA)..............II-55 Integra LifeSciences Holdings Corporation (USA) II-55 LifeNet Health, Inc. (USA)..............II-56 Medtronic plc (Ireland)..............II-56 NovaBone Products LLC (USA)..............II-56 NuVasive, Inc. (USA)..............II-57 Orthofix International N V (Curaçao) II-57 RTI Surgical, Inc. (USA)..............II-58 Smith & Nephew Plc (UK)..............II-58 Stryker Corporation (USA)..............II-58 Wright Medical Group N.V. (Netherlands) II-59 Zimmer Biomet Holdings, Inc. (USA) II-60

8. GLOBAL MARKET PERSPECTIVE..............II-61 Table 8: World Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - US, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart)..............II-61

Table 9: World Historic Review for Bone Graft Substitutes by Geographic Region/ Country - US, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart) II-62

Table 10: World 14-Year Perspective for Bone Graft Substitutes by Geographic Region/Country - Percentage Breakdown of Revenues for US, Japan, Europe, Asia-Pacific, Latin America and Rest of World Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) II-63

III. MARKET

1. THE UNITED STATES.............. III-1 A.Market Analysis.............. III-1 Bone Graft Substitutes Market: Promising Opportunities Ahead III-1 Aging Population: A Weighty Demographic Growth Factor III-2 Table 11: North American Elderly Population by Age Group (1975-2050) (includes corresponding Graph/Chart) III-3

Table 12: US Population Breakdown by Age Group (2015) (includes corresponding Graph/Chart) III-3 Rising Incidence of Degenerative Intervertebral Disc Diseases III-3 Back Pain.............. III-4 Arthritis.............. III-4 Table 13: % of Population Diagnosed with Arthritis by Age Group (includes corresponding Graph/Chart) III-5 Osteoporosis.............. III-5 Table 14: Osteoporosis Population in the US: 2002, 2005, 2008 & 2012 (includes corresponding Graph/Chart) III-6

Table 15: Breakdown of Osteoporotic Fractures by Site in the US (includes corresponding Graph/Chart) III-6 Rise in Revision Orthopedic Surgeries Bodes Well for Bone Graft Substitutes Market..............III-6 Unmet Clinical Needs to Foster R&D Engine III-6 Synthetic Bone Grafts to Fan Growth III-7 Orthopedic Growth Factors Market - Safety Concerns of INFUSE® Affect Growth..............III-7 Stem Cell Bone Grafts: A Promising Segment in BGS Market III-7 Spinal Surgery Market: Opportunity for Bone Grafts Market III-8 Dental Bone Graft Substitutes Market: An Overview III-8 Orthopedic Biomaterials Market - An Overview III-9 Orthobiologics Market - Overview III-9 Regulatory Challenges Limit Growth in the Bone Graft Substitutes.............. III-10 Competitive Scenario..............III-10 Table 16: US Market for Bone Graft Substitutes (2014): Percentage Market Share Breakdown of Leading Suppliers for Bacterin, DePuy Synthes, LifeNet, Medtronic, MTF, NuVasive, Stryker and Others (includes corresponding Graph/Chart) III-11

Table 17: US Market for Synthetic Bone Grafts (2014): Percentage Market Share Breakdown of Leading Suppliers for Baxter, DePuy Synthes, Integra, Medtronic, NuVasive, and Stryker (includes corresponding Graph/Chart) III-11

Table 18: US Market for Allografts Demineralized Bone Matrix (DBM) (2014): Percentage Market Share Breakdown of Leading Suppliers for Bacterin, Integra, LifeNet, Medtronic, MTF and Others (includes corresponding Graph/Chart).............. III-12

Table 19: US Market for Cell-based Combinations Bone Graft Substitutes (2014): Percentage Market Share Breakdown of Leading Suppliers for MTF and NuVasive (includes corresponding Graph/Chart)..............III-12 Product Launches..............III-12 Strategic Corporate Developments III-14 Select Players.............. III-17 B.Market Analytics..............III-22 Table 20: US Recent Past, Current and Future Analysis for Bone Graft Substitutes by Product Segment - Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Grafts, and Synthetic Bone Grafts Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-22

Table 21: US Historic Review for Bone Graft Substitutes by Product Segment - Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Grafts, and Synthetic Bone Grafts Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart) III-23

Table 22: US 14-Year Perspective for Bone Graft Substitutes by Product Segment - Percentage Breakdown of Revenues for Demineralized Bone Matrix (DBM), Bone Morphogenetic Protein (BMP), Stem Cell Based Grafts, and Synthetic Bone Grafts Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart).............. III-24

2. JAPAN.............. III-25 A.Market Analysis.............. III-25 Current and Future Analysis..............III-25 Dental Bone Graft Substitutes Market III-25 Table 23: Dental Bone Graft Substitutes Market in Japan (2015E): Percentage Share Breakdown of Volume Sales for Synthetic Graft and Xenograft (includes corresponding Graph/Chart).............. III-25 B.Market Analytics..............III-26 Table 24: Japanese Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-26

Table 25: Japanese Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-27

3. EUROPE.............. III-28 A.Market Analysis.............. III-28 European Market for Bone Graft Substitutes: An Overview III-28 Table 26: European Bone Graft Substitutes Market (2012): Percentage Share Breakdown of Value Sales for Synthetic, Allograft, and DBM (includes corresponding Graph/Chart) III-28 Synthetic Bone Graft Drives the BGS Market III-29 Bone Morphogenetic Protein (BMP) Market III-29 Orthopedic Biomaterials Market - An Overview III-29 Dental Biomaterials Market in Europe: An Insight III-30 Regulatory Overview..............III-31 EU Directive 2003/32/EC..............III-31 DBM-based Products in Europe..............III-31 B.Market Analytics..............III-32 Table 27: European Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart).............. III-32

Table 28: European Historic Review for Bone Graft Substitutes by Geographic Region/Country - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart) III-33

Table 29: European 14-Year Perspective for Bone Graft Substitutes by Geographic Region/ Country - Percentage Breakdown of Revenues for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-34

3a. FRANCE.............. III-35 Market Analysis.............. III-35 Table 30: French Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-35

Table 31: French Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-36

3b. GERMANY.............. III-37 Market Analysis.............. III-37 Table 32: German Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-37

Table 33: German Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-38

3c. ITALY.............. III-39 Market Analysis.............. III-39 Table 34: Italian Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-39

Table 35: Italian Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-40

3d. THE UNITED KINGDOM..............III-41 A.Market Analysis.............. III-41 Current and Future Analysis..............III-41 Key Player.............. III-41 B.Market Analytics..............III-42 Table 36: UK Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart)..............III-42

Table 37: UK Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-43

3e. SPAIN.............. III-44 Market Analysis.............. III-44 Table 38: Spanish Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-44

Table 39: Spanish Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-45

3f. REST OF EUROPE.............. III-46 A.Market Analysis.............. III-46 Current and Future Analysis..............III-46 Product Launches..............III-46 Strategic Corporate Developments III-46 Select Players.............. III-46 B.Market Analytics..............III-48 Table 40: Rest of Europe Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-48

Table 41: Rest of Europe Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-49

4. ASIA-PACIFIC.............. III-50 A.Market Analysis.............. III-50 Current and Future Analysis..............III-50 Dental Bone Graft Substitutes Market in Asia-Pacific - An Overview.............. III-50 Table 42: Leading Players in the Dental Bone Graft Substitutes Market in Asia-Pacific (2015E): Percentage Share Breakdown of Sales for Geistlich and Others (includes corresponding Graph/Chart)..............III-51

Table 43: Over 65 Years Individuals as % of Total Population in Select Asian Countries (2015) (includes corresponding Graph/Chart)..............III-51 B.Market Analytics..............III-52 Table 44: Asia-Pacific Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region/Country - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart)..............III-52

Table 45: Asia-Pacific Historic Review for Bone Graft Substitutes by Geographic Region/Country - China, India and Rest of Asia-Pacific Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart) III-53

Table 46: Asia-Pacific 14-Year Perspective for Bone Graft Substitutes by Geographic Region/Country - Percentage Breakdown of Revenues for China, India and Rest of Asia-Pacific Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart)..............III-54

4a. CHINA.............. III-55 A.Market Analysis.............. III-55 Market Overview.............. III-55 Table 47: Dental Bone Graft Substitutes Market in China (2015E): Percentage Share Breakdown of Volume Sales by Segment - Allograft, Synthetic Graft and Xenograft (includes corresponding Graph/Chart) III-55 B.Market Analytics..............III-56 Table 48: Chinese Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-56

Table 49: Chinese Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-57

4b. INDIA.............. III-58 A.Market Analysis.............. III-58 Current and Future Analysis..............III-58 Product Approval..............III-58 B.Market Analytics..............III-59 Table 50: Indian Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-59

Table 51: Indian Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart).............. III-60

4c. REST OF ASIA-PACIFIC..............III-61 A.Market Analysis.............. III-61 Current and Future Analysis..............III-61 Focus on Select Regional Markets III-61 Australia.............. III-61 Table 52: Dental Bone Graft Substitutes Market in Australia (2020P): Percentage Share Breakdown of Volume Sales by Segment - Demineralized Allografts, Mineralized Allografts, Synthetic Grafts, and Xenografts (includes corresponding Graph/Chart) III-61 Malaysia.............. III-61 South Korea.............. III-62 Table 53: Dental Bone Graft Substitutes Market in South Korea (2015E): Percentage Share Breakdown of Volume Sales by Material - Allograft, Synthetic Graft and Xenograft (includes corresponding Graph/Chart) III-62 Singapore.............. III-62 B.Market Analytics..............III-63 Table 54: Rest of Asia-Pacific Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-63

Table 55: Rest of Asia-Pacific Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-64

5. LATIN AMERICA.............. III-65 A.Market Analysis.............. III-65 Current and Future Analysis..............III-65 Dental Bone Graft Substitutes Market - Overview III-65 Overview of Brazilian Orthopedic Devices Market III-65 Select Player.............. III-65 B.Market Analytics..............III-66 Table 56: Latin American Recent Past, Current and Future Analysis for Bone Graft Substitutes by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-66

Table 57: Latin American Historic Review for Bone Graft Substitutes by Geographic Region - Brazil and Rest of Latin America Markets Independently Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-67

Table 58: Latin American 14-Year Perspective for Bone Graft Substitutes by Geographic Region - Percentage Breakdown of Revenues for Brazil and Rest of Latin America Markets for Years 2009, 2016 & 2022 (includes corresponding Graph/Chart) III-68

6. REST OF WORLD.............. III-69 A.Market Analysis.............. III-69 Current and Future Analysis..............III-69 Canada.............. III-69 Product Launch.............. III-69 B.Market Analytics..............III-70 Table 59: Rest of World Recent Past, Current and Future Analysis for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2015 through 2022 (includes corresponding Graph/Chart) III-70

Table 60: Rest of World Historic Review for Bone Graft Substitutes Market Analyzed with Annual Revenue Figures in US$ Million for Years 2009 through 2014 (includes corresponding Graph/Chart)..............III-71

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 57 (including Divisions/Subsidiaries - 61)

The United States (39) Canada (1) Europe (17) - France (2) - Germany (2) - The United Kingdom (4) - Rest of Europe (9) Asia-Pacific (Excluding Japan) (3) Africa (1)
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