Integrated Surgical Systems Announces the Sale of ROBODOC(R) Surgical Assistant System to a Major Former Orto Maquet Customer in Germany.

Apr 27, 2001, 01:00 ET from Integrated Surgical Systems, Inc.

    DAVIS, Calif., April 27 /PRNewswire/ -- Integrated Surgical Systems, Inc.
 (ISS) (OTC Bulletin Board:   RDOC) a pioneer in medical robotics and the world
 leader in image-directed, semi-autonomous robotic products for surgical
 applications, announced today that it received an order for the ROBODOC(R)
 Surgical Assistant System for immediate delivery to Ev. Luth Diakonessen
 Mutterhaus in Rotenburg, Germany.
     (Photo:  NewsCom:  http://www.newscom.com/cgi-bin/prnh/20000329/SFW037 )
     "This represents the first conversion to the ROBODOC(R) Surgical Assistant
 System since former OrtoMaquet, suppliers of the CASPAR system, announced its
 decision to immediately close its operation as of March 31, 2001," said Dr.
 Ramesh Trivedi, President & CEO of Integrated Surgical Systems. "This
 development is very significant because Dr. Rudolph, chief of the orthopedic
 and traumatology departments and the clinic was the first to buy the CASPAR
 system three years ago. This shows their positive experience with the robotics
 technology and belief that the ROBODOC System is the only proven viable system
 in the market."
     Commenting on the current situation Dr. Rudolph stated that, "We have
 patients waiting for several months to perform the total hip surgeries with
 the robotic system. It is not appropriate to make them wait longer." On his
 quick decision to switch to the ROBODOC System, Dr. Rudolph commented, "Any
 interim solution to continue to use the CASPAR system would leave the long
 term problems unresolved. We do not believe that anyone can continue to
 develop and support the CASPAR system with new applications such as total knee
 surgeries, revision hip surgeries, acetabular planning and replacement, spine
 surgeries, etc. We do not want to subject our patients to an obsolete system."
     The Vice-Manager of the clinic, Mr. Quaschner stated that "I totally agree
 with Dr. Rudolph's comment. Even though this represent additional cost to the
 clinic, it is the right decision for our patients."
     In other matters, after serving for five years as a member of the Board of
 Directors of ISS, Dr. John Kapoor has resigned as its director, effective
 immediately, due to an increased amount of time that needs to spend with his
 portfolio of companies. "The company will greatly miss the help and support of
 Dr. Kapoor," said Dr. Ramesh Trivedi.
 
     The Products:
     ROBODOC is the robotic surgery system of ISS that is used for total joint
 arthoplasties. ROBODOC consists of a robotic arm assembly and a PC-based 3-D
 planning station called ORTHODOC(R). ISS has installed 37 ROBODOC systems
 worldwide. The ISS neurosurgery product, NeuroMate(TM), is the first robotic
 technology based system for use in stereotactic brain surgery. NeuroMate
 consists of a robotic arm assembly and a PC-based planning system. NeuroMate
 also interfaces with other popular planning stations offered by third-party
 vendors. ISS has installed 16 NeuroMate systems in the U.S., Europe and Japan.
 
     The Company:
     Integrated Surgical Systems, Inc. develops, manufactures, markets and
 services computer-controlled, image-directed robotic products for surgical
 applications. ISS produces the ROBODOC Surgical Assistant System (ROBODOC),
 which is designed for orthopedic applications. The ROBODOC System has been
 used to perform successful total hip replacement surgeries on more than
 8,000 patients worldwide. ROBODOC is currently being marketed in Europe and
 the Middle East. NeuroMate(TM), an ISS neurosurgery product, is the first
 robotic technology for use in stereotactic brain surgery and it has supported
 to date over 3,000 neurosurgical procedures.
     Except for the historical information contained herein, the matters
 discussed in this news release are forward-looking statements that involve
 risks and uncertainties, including the timely development and market
 acceptance of new products and upgrades to existing products, the impact of
 competitive products and pricing, and other risks detailed from time to time
 in the company's filings with the Securities and Exchange Commission (SEC).
     NOTE:  ROBODOC(R) is a registered trademark of Integrated Surgical Systems,
 Inc. NeuroMate(TM) is a trademark of Integrated Surgical Systems, S.A.
 
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SOURCE Integrated Surgical Systems, Inc.
    DAVIS, Calif., April 27 /PRNewswire/ -- Integrated Surgical Systems, Inc.
 (ISS) (OTC Bulletin Board:   RDOC) a pioneer in medical robotics and the world
 leader in image-directed, semi-autonomous robotic products for surgical
 applications, announced today that it received an order for the ROBODOC(R)
 Surgical Assistant System for immediate delivery to Ev. Luth Diakonessen
 Mutterhaus in Rotenburg, Germany.
     (Photo:  NewsCom:  http://www.newscom.com/cgi-bin/prnh/20000329/SFW037 )
     "This represents the first conversion to the ROBODOC(R) Surgical Assistant
 System since former OrtoMaquet, suppliers of the CASPAR system, announced its
 decision to immediately close its operation as of March 31, 2001," said Dr.
 Ramesh Trivedi, President & CEO of Integrated Surgical Systems. "This
 development is very significant because Dr. Rudolph, chief of the orthopedic
 and traumatology departments and the clinic was the first to buy the CASPAR
 system three years ago. This shows their positive experience with the robotics
 technology and belief that the ROBODOC System is the only proven viable system
 in the market."
     Commenting on the current situation Dr. Rudolph stated that, "We have
 patients waiting for several months to perform the total hip surgeries with
 the robotic system. It is not appropriate to make them wait longer." On his
 quick decision to switch to the ROBODOC System, Dr. Rudolph commented, "Any
 interim solution to continue to use the CASPAR system would leave the long
 term problems unresolved. We do not believe that anyone can continue to
 develop and support the CASPAR system with new applications such as total knee
 surgeries, revision hip surgeries, acetabular planning and replacement, spine
 surgeries, etc. We do not want to subject our patients to an obsolete system."
     The Vice-Manager of the clinic, Mr. Quaschner stated that "I totally agree
 with Dr. Rudolph's comment. Even though this represent additional cost to the
 clinic, it is the right decision for our patients."
     In other matters, after serving for five years as a member of the Board of
 Directors of ISS, Dr. John Kapoor has resigned as its director, effective
 immediately, due to an increased amount of time that needs to spend with his
 portfolio of companies. "The company will greatly miss the help and support of
 Dr. Kapoor," said Dr. Ramesh Trivedi.
 
     The Products:
     ROBODOC is the robotic surgery system of ISS that is used for total joint
 arthoplasties. ROBODOC consists of a robotic arm assembly and a PC-based 3-D
 planning station called ORTHODOC(R). ISS has installed 37 ROBODOC systems
 worldwide. The ISS neurosurgery product, NeuroMate(TM), is the first robotic
 technology based system for use in stereotactic brain surgery. NeuroMate
 consists of a robotic arm assembly and a PC-based planning system. NeuroMate
 also interfaces with other popular planning stations offered by third-party
 vendors. ISS has installed 16 NeuroMate systems in the U.S., Europe and Japan.
 
     The Company:
     Integrated Surgical Systems, Inc. develops, manufactures, markets and
 services computer-controlled, image-directed robotic products for surgical
 applications. ISS produces the ROBODOC Surgical Assistant System (ROBODOC),
 which is designed for orthopedic applications. The ROBODOC System has been
 used to perform successful total hip replacement surgeries on more than
 8,000 patients worldwide. ROBODOC is currently being marketed in Europe and
 the Middle East. NeuroMate(TM), an ISS neurosurgery product, is the first
 robotic technology for use in stereotactic brain surgery and it has supported
 to date over 3,000 neurosurgical procedures.
     Except for the historical information contained herein, the matters
 discussed in this news release are forward-looking statements that involve
 risks and uncertainties, including the timely development and market
 acceptance of new products and upgrades to existing products, the impact of
 competitive products and pricing, and other risks detailed from time to time
 in the company's filings with the Securities and Exchange Commission (SEC).
     NOTE:  ROBODOC(R) is a registered trademark of Integrated Surgical Systems,
 Inc. NeuroMate(TM) is a trademark of Integrated Surgical Systems, S.A.
 
                      MAKE YOUR OPINION COUNT - Click Here
                http://tbutton.prnewswire.com/prn/11690X73864571
 
 SOURCE  Integrated Surgical Systems, Inc.