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Reportlinker Adds Global G-Protein Coupled Receptors (GPCRs) Industry


News provided by

Reportlinker

Mar 22, 2011, 06:57 ET

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NEW YORK, March 22, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Global G-Protein Coupled Receptors (GPCRs) Industry

http://www.reportlinker.com/p0197194/Global-G-Protein-Coupled-Receptors-GPCRs-Industry.html

This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in US$ Billion. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a six-year historic analysis is provided for these markets. The report profiles 43 companies including 7TM Pharma A/S, Actelion Pharmaceuticals Ltd., Acure Pharma AB, Anchor Therapeutics, Arena Pharmaceuticals, Inc., Addex Pharmaceuticals, Acadia Pharmaceuticals Inc., Cara Therapeutics, Inc., DiscoveRx Corporation, Dimerix Bioscience Pty Ltd., Domain Therapeutics, Euroscreen SA, Millipore Corporation, and Trevena, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1

Study Reliability and Reporting Limitations 1

Disclaimers 2

Data Interpretation & Reporting Level 3

Quantitative Techniques & Analytics 3

Product Definitions and Scope of Study 3

2. INDUSTRY OVERVIEW 4

A Quick Primer 4

Why GPCRs Are Important? 4

Illustrative Examples of Currently Available Pharmaceutical

Drugs Targeting GPCRs 4

Untapped Pharmacological Potential of GPCRs Ignites Interest 5

Popular Types of GPCRs of Therapeutic Interest Currently

Being Studied Include: 6

Current Knowledge of GPCR Crystal Structures Just the Tip of

the Iceberg 6

NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures 7

Orphan GPCRs: A Promising Area for Drug Discovery 7

Developments in Screening Technology for GPCRs 8

Cell Membrane Assays for GPCR Quantitative Analysis 8

What's in for the Pharmaceutical Industry? 8

Challenges Aplenty in the GPCR Space 9

Addressing Orphan GPCRs 9

Lack of Structural Information 9

Identification and Classification of Allosteric Sites 9

3. G-PROTEIN COUPLED RECEPTORS (GPCR) - A CONCEPTUAL OVERVIEW 10

GPCR: Gateways to Cell 10

Classification of GPCRs 10

Table 1: List of Identified Known and Orphan (Non-Sensory)

GPCRs in Human Genome (includes corresponding Graph/Chart) 11

Orphan GPCRs and Deorphanization 11

List of oGPCR-Ligand Pairings Identified By Using Reverse

Pharmacology Approach 12

Structural Information 12

Rhodopsin: A Well Studied GPCR 13

Crystal Structure of Human Beta-2 Adrenergic GPCR 13

Structure of Human A2A Adenosine Receptor 13

Significance of GPCR Crystal Structures 14

GPCR Signaling Pathways 14

Physiological Roles Performed by GPCRs 14

Visual Sense 14

Cell-density Sensing 14

Regulation of mood and behavior 14

Smelling Sense 14

Regulating Immune-System Inflammation and Activity 15

Automatic Transmission of Nervous System 15

Receptor - Ligand Interaction 15

Types of Ligands 15

Therapeutic Potential of GPCRs 15

List of Major Disease States and Associated Known GPCRs 16

Allosteric Modulators and Implication of Allostery in Drug

Discovery 16

Advantages of Allosteric Modulators 16

Dimerisation and Role of Dimers in Drug Discovery 17

Oligomerisation and Role of Oligomers in Drug Discovery 17

Functional Selectivity 17

Existing Drug Candidates in GPCR Space 18

List of Existing GPCR-Based Drugs Available In Market Along

With Their Target Receptor and Indication 18

Pipeline GPCR Drug Candidates 18

Ion Channels 19

Approaches to Drug Discovery in GPCR Space 19

Structure-Based Drug Discovery 19

Ligand-Based Drug Discovery 19

Target-Based Drug Discovery 19

GPCR Screening and Targeting Technologies 19

Cell-Based Screening Assays 20

Virtual Screening 21

Fragment screening 21

4. RECENT INDUSTRY ACTIVITY 22

Domain Therapeutics Enters into an Agreement with Merck Serono 22

Anchor Therapeutics Makes a Breakthrough in GPCR Collaboration 22

Receptos Collaborates with Lilly GPCR target 22

Sanofi-aventis Enters into Licensing Agreement with Metabolex 23

Neurocrine and Boehringer Ingelheim Join Hands to Develop

GPR119 Agonists 23

Affitech Enters into Research Collaboration with NTS Plus 23

Takeda Cambridge Inks an Agreement to Utilize Dimerix' GPCR-

HIT Platform 24

PerkinElmer Unveils New Detection Kit for Profiling and

Screeing GPCRs 24

Omeros Completes Acquisition of GPCR Assay Technology from

Patobios 25

DiscoveRx Corporation Takes Over KINOMEscan™ 25

Roche and ATCC Collaborate on Real-Time Endogenous GPCR

Function Research 25

Millipore Launches Luminescent GPCR Reporter Frozen Cells 25

Ascent Therapeutics re-christened as Anchor Therapeutics 25

Affitech Sells Cancer Vaccine Project to Focus on GPCR Research 26

Medarex Releases Pre-clinical Data for MDX-1338 26

Compugen Declares Positive Therapeutic Effects of CGEN-25009 26

Addex Releases Clinical Data for ADX10059 26

Arana Receives Patent Approval for PMX53 and Related GPCR

Compounds 27

Epix Pharmaceuticals Receives Patent Approval for PRX-03140

and Related Compounds 27

Odyssey Thera Receives Patent Approval for Fluorescence-Based

Assays 27

Cisbio Bioassays Introduces Cellul'erk Assay 27

DiscoveRx Introduces Products and Services to Assays and

Reagents Portfolio 28

PerkinElmer Introduces Novel Ion Channel and GPCR Cell Lines 28

Millipore Launches New AllostericProfilerTM Service 28

Ligand Pharmaceuticals and Trevena Enter into Agreement 28

ChanTest Takes Over ACS 29

PerkinElmer Enters into Collaboration with Sangmyung University 29

Debiopharm Group Inks Exclusive Agreement with MSM Protein

Technologies 29

GVK Biosciences and University of Tokyo Sign Agreement 29

MSM Protein Technologies Enters into Alliance with Merck Serono 30

Xenome Enters into Agreement with Axxam 30

DiscoveRx and GlaxoSmithKline Inks Global Agreement 30

Sygnature Enters into Contract Chemistry Agreement with

Heptares Therapeutics 30

Enzo Life Sciences Enters into Partnership with BioTek

Instruments 31

Heptares Therapeutics Enters into Agreement with Novartis

Option Fund 31

CellAura Enters into Partnership with Cisbio Bioassays 31

Euroscreen and Novartis Ink Research Collaboration Agreement 31

Evotec Enters into Co-marketing Agreement with DiscoveRx 32

Jubilant Biosys Inks Co-marketing Agreement with DiscoveRx 32

Faust Pharmaceuticals Changes Name to Domain Therapeutics 32

GSK, MRCT and DiscoveRx Collaborate for Deorphanization of GPCRs 32

DiscoveRx Inks Agreement with BioFocus 33

Actelion's S1P1 Receptor Agonist to Enter into Phase II

Clinical Trial 33

AnaSpec Introduces Two Isoform Specific Antibodies 33

Millipore Introduces MultiScreen®HTS+ Filter Plates 33

Faust & Takeda Enter into Research Agreement 34

Caliper Life Sciences Collaborates with DiscoveRx 34

Compugen Inks Agreement with Merck Serono 34

BioFocus and Amgen Extend Drug Discovery Agreement 34

DiscoveRx Selects Cosmo Bio to Distribute GPCR Profiling

Service across Japan 34

Euroscreen Extends Agreement with Cephalon 35

BioFocus DPI Introduces Novel Version of GPCR SARfari 35

PerkinElmer Takes Over Euroscreen Products 35

5. FOCUS ON SELECT GLOBAL PLAYERS 36

7TM Pharma A/S (Denmark) 36

Actelion Pharmaceuticals Ltd. (Switzerland) 36

Acure Pharma AB (Sweden) 36

Anchor Therapeutics (USA) 37

Arena Pharmaceuticals, Inc. (US) 37

Addex Pharmaceuticals (Switzerland) 37

Acadia Pharmaceuticals Inc., (USA) 38

Cara Therapeutics, Inc. (USA) 39

DiscoveRx Corporation (USA) 39

Dimerix Bioscience Pty Ltd (Australia) 39

Domain Therapeutics (France) 40

Euroscreen SA (Belgium) 40

Millipore Corporation (US) 40

Trevena, Inc. (USA) 41

6. GLOBAL MARKET PERSPECTIVE 42

Table 2: World Recent Past, Current & Future Market Analysis

for G-Protein Coupled Receptors (GPCRs) Addressing Drugs With

Annual Sales Figures in US$ Billion for Years 2007 through

2015 (includes corresponding Graph/Chart) 42

Table 3: World Historic Review for G-Protein Coupled Receptors

(GPCRs) Addressing Drugs With Annual Sales Figures in US$

Billion for Years 2001 through 2006 (includes corresponding

Graph/Chart) 42

COMPETITIVE LANDSCAPE

Total Companies Profiled: 43

------------------------------------------

Region/Country Players

------------------------------------------

The United States 24

Europe 15

France 2

Germany 1

The United Kingdom 3

Italy 1

Rest of Europe 8

Asia-Pacific (Excluding Japan) 3

Middle-East 1

------------------------------------------

To order this report:

: Global G-Protein Coupled Receptors (GPCRs) Industry

More  Market Research Report

Check our  Company Profile, SWOT and Revenue Analysis!

Contact:
Nicolas Bombourg
Reportlinker
Email: [email protected]
US: (805)652-2626
Intl: +1 805-652-2626

SOURCE Reportlinker

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