Reportlinker Adds Global G-Protein Coupled Receptors (GPCRs) Industry
NEW YORK, March 22, 2011 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Global G-Protein Coupled Receptors (GPCRs) Industry
http://www.reportlinker.com/p0197194/Global-G-Protein-Coupled-Receptors-GPCRs-Industry.html
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs) in US$ Billion. Annual estimates and forecasts are provided for the period 2007 through 2015. Also, a six-year historic analysis is provided for these markets. The report profiles 43 companies including 7TM Pharma A/S, Actelion Pharmaceuticals Ltd., Acure Pharma AB, Anchor Therapeutics, Arena Pharmaceuticals, Inc., Addex Pharmaceuticals, Acadia Pharmaceuticals Inc., Cara Therapeutics, Inc., DiscoveRx Corporation, Dimerix Bioscience Pty Ltd., Domain Therapeutics, Euroscreen SA, Millipore Corporation, and Trevena, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1
Study Reliability and Reporting Limitations 1
Disclaimers 2
Data Interpretation & Reporting Level 3
Quantitative Techniques & Analytics 3
Product Definitions and Scope of Study 3
2. INDUSTRY OVERVIEW 4
A Quick Primer 4
Why GPCRs Are Important? 4
Illustrative Examples of Currently Available Pharmaceutical
Drugs Targeting GPCRs 4
Untapped Pharmacological Potential of GPCRs Ignites Interest 5
Popular Types of GPCRs of Therapeutic Interest Currently
Being Studied Include: 6
Current Knowledge of GPCR Crystal Structures Just the Tip of
the Iceberg 6
NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures 7
Orphan GPCRs: A Promising Area for Drug Discovery 7
Developments in Screening Technology for GPCRs 8
Cell Membrane Assays for GPCR Quantitative Analysis 8
What's in for the Pharmaceutical Industry? 8
Challenges Aplenty in the GPCR Space 9
Addressing Orphan GPCRs 9
Lack of Structural Information 9
Identification and Classification of Allosteric Sites 9
3. G-PROTEIN COUPLED RECEPTORS (GPCR) - A CONCEPTUAL OVERVIEW 10
GPCR: Gateways to Cell 10
Classification of GPCRs 10
Table 1: List of Identified Known and Orphan (Non-Sensory)
GPCRs in Human Genome (includes corresponding Graph/Chart) 11
Orphan GPCRs and Deorphanization 11
List of oGPCR-Ligand Pairings Identified By Using Reverse
Pharmacology Approach 12
Structural Information 12
Rhodopsin: A Well Studied GPCR 13
Crystal Structure of Human Beta-2 Adrenergic GPCR 13
Structure of Human A2A Adenosine Receptor 13
Significance of GPCR Crystal Structures 14
GPCR Signaling Pathways 14
Physiological Roles Performed by GPCRs 14
Visual Sense 14
Cell-density Sensing 14
Regulation of mood and behavior 14
Smelling Sense 14
Regulating Immune-System Inflammation and Activity 15
Automatic Transmission of Nervous System 15
Receptor - Ligand Interaction 15
Types of Ligands 15
Therapeutic Potential of GPCRs 15
List of Major Disease States and Associated Known GPCRs 16
Allosteric Modulators and Implication of Allostery in Drug
Discovery 16
Advantages of Allosteric Modulators 16
Dimerisation and Role of Dimers in Drug Discovery 17
Oligomerisation and Role of Oligomers in Drug Discovery 17
Functional Selectivity 17
Existing Drug Candidates in GPCR Space 18
List of Existing GPCR-Based Drugs Available In Market Along
With Their Target Receptor and Indication 18
Pipeline GPCR Drug Candidates 18
Ion Channels 19
Approaches to Drug Discovery in GPCR Space 19
Structure-Based Drug Discovery 19
Ligand-Based Drug Discovery 19
Target-Based Drug Discovery 19
GPCR Screening and Targeting Technologies 19
Cell-Based Screening Assays 20
Virtual Screening 21
Fragment screening 21
4. RECENT INDUSTRY ACTIVITY 22
Domain Therapeutics Enters into an Agreement with Merck Serono 22
Anchor Therapeutics Makes a Breakthrough in GPCR Collaboration 22
Receptos Collaborates with Lilly GPCR target 22
Sanofi-aventis Enters into Licensing Agreement with Metabolex 23
Neurocrine and Boehringer Ingelheim Join Hands to Develop
GPR119 Agonists 23
Affitech Enters into Research Collaboration with NTS Plus 23
Takeda Cambridge Inks an Agreement to Utilize Dimerix' GPCR-
HIT Platform 24
PerkinElmer Unveils New Detection Kit for Profiling and
Screeing GPCRs 24
Omeros Completes Acquisition of GPCR Assay Technology from
Patobios 25
DiscoveRx Corporation Takes Over KINOMEscan™ 25
Roche and ATCC Collaborate on Real-Time Endogenous GPCR
Function Research 25
Millipore Launches Luminescent GPCR Reporter Frozen Cells 25
Ascent Therapeutics re-christened as Anchor Therapeutics 25
Affitech Sells Cancer Vaccine Project to Focus on GPCR Research 26
Medarex Releases Pre-clinical Data for MDX-1338 26
Compugen Declares Positive Therapeutic Effects of CGEN-25009 26
Addex Releases Clinical Data for ADX10059 26
Arana Receives Patent Approval for PMX53 and Related GPCR
Compounds 27
Epix Pharmaceuticals Receives Patent Approval for PRX-03140
and Related Compounds 27
Odyssey Thera Receives Patent Approval for Fluorescence-Based
Assays 27
Cisbio Bioassays Introduces Cellul'erk Assay 27
DiscoveRx Introduces Products and Services to Assays and
Reagents Portfolio 28
PerkinElmer Introduces Novel Ion Channel and GPCR Cell Lines 28
Millipore Launches New AllostericProfilerTM Service 28
Ligand Pharmaceuticals and Trevena Enter into Agreement 28
ChanTest Takes Over ACS 29
PerkinElmer Enters into Collaboration with Sangmyung University 29
Debiopharm Group Inks Exclusive Agreement with MSM Protein
Technologies 29
GVK Biosciences and University of Tokyo Sign Agreement 29
MSM Protein Technologies Enters into Alliance with Merck Serono 30
Xenome Enters into Agreement with Axxam 30
DiscoveRx and GlaxoSmithKline Inks Global Agreement 30
Sygnature Enters into Contract Chemistry Agreement with
Heptares Therapeutics 30
Enzo Life Sciences Enters into Partnership with BioTek
Instruments 31
Heptares Therapeutics Enters into Agreement with Novartis
Option Fund 31
CellAura Enters into Partnership with Cisbio Bioassays 31
Euroscreen and Novartis Ink Research Collaboration Agreement 31
Evotec Enters into Co-marketing Agreement with DiscoveRx 32
Jubilant Biosys Inks Co-marketing Agreement with DiscoveRx 32
Faust Pharmaceuticals Changes Name to Domain Therapeutics 32
GSK, MRCT and DiscoveRx Collaborate for Deorphanization of GPCRs 32
DiscoveRx Inks Agreement with BioFocus 33
Actelion's S1P1 Receptor Agonist to Enter into Phase II
Clinical Trial 33
AnaSpec Introduces Two Isoform Specific Antibodies 33
Millipore Introduces MultiScreen®HTS+ Filter Plates 33
Faust & Takeda Enter into Research Agreement 34
Caliper Life Sciences Collaborates with DiscoveRx 34
Compugen Inks Agreement with Merck Serono 34
BioFocus and Amgen Extend Drug Discovery Agreement 34
DiscoveRx Selects Cosmo Bio to Distribute GPCR Profiling
Service across Japan 34
Euroscreen Extends Agreement with Cephalon 35
BioFocus DPI Introduces Novel Version of GPCR SARfari 35
PerkinElmer Takes Over Euroscreen Products 35
5. FOCUS ON SELECT GLOBAL PLAYERS 36
7TM Pharma A/S (Denmark) 36
Actelion Pharmaceuticals Ltd. (Switzerland) 36
Acure Pharma AB (Sweden) 36
Anchor Therapeutics (USA) 37
Arena Pharmaceuticals, Inc. (US) 37
Addex Pharmaceuticals (Switzerland) 37
Acadia Pharmaceuticals Inc., (USA) 38
Cara Therapeutics, Inc. (USA) 39
DiscoveRx Corporation (USA) 39
Dimerix Bioscience Pty Ltd (Australia) 39
Domain Therapeutics (France) 40
Euroscreen SA (Belgium) 40
Millipore Corporation (US) 40
Trevena, Inc. (USA) 41
6. GLOBAL MARKET PERSPECTIVE 42
Table 2: World Recent Past, Current & Future Market Analysis
for G-Protein Coupled Receptors (GPCRs) Addressing Drugs With
Annual Sales Figures in US$ Billion for Years 2007 through
2015 (includes corresponding Graph/Chart) 42
Table 3: World Historic Review for G-Protein Coupled Receptors
(GPCRs) Addressing Drugs With Annual Sales Figures in US$
Billion for Years 2001 through 2006 (includes corresponding
Graph/Chart) 42
COMPETITIVE LANDSCAPE
Total Companies Profiled: 43
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Region/Country Players
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The United States 24
Europe 15
France 2
Germany 1
The United Kingdom 3
Italy 1
Rest of Europe 8
Asia-Pacific (Excluding Japan) 3
Middle-East 1
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To order this report:
: Global G-Protein Coupled Receptors (GPCRs) Industry
Check our Company Profile, SWOT and Revenue Analysis!
Contact:
Nicolas Bombourg
Reportlinker
Email: [email protected]
US: (805)652-2626
Intl: +1 805-652-2626
SOURCE Reportlinker
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