The Global Non-Invasive Prenatal Diagnostics Market

NEW YORK, Aug. 19, 2014 Reportlinker.com announces that a new market research report is available in its catalogue:

The Global Non-Invasive Prenatal Diagnostics Market

http://www.reportlinker.com/p02264763/The-Global-Non-Invasive-Prenatal-Diagnostics-Market.html

ES.1 Introduction to the Non-invasive Prenatal Diagnostics Market

The aim of this report was to review recent advances in use of circulating cell-free miRNA, DNA and mRNA as novel biomarkers which can be used as a non-invasive method for prenatal diagnostics. The report will also provide a market analysis of the market value, growth rates and market development as well as examining the dynamics and factors influencing the growth and development of this market. This report also looks at the challenges and potential threats facing the industry, and the factors influencing the market shares of the major market suppliers as well as smaller indigenous manufacturers in local markets.

The data collection and forecasting methods used in the preparation of this report are broadly divided into three methods. These are primary data and information gathering, secondary data and information gathering and market share analysis and market forecast prediction. Information and data including estimates on market values, growth rates and market share data were gathered from the methods described and were incorporated into proprietary computer forecasting and market share analysis models.
The forecast model was used to derive market estimates for future years. It incorporates a rate factor, which helps determine the speed with which the market develops, which is similar to that observed for markets for other medical products and is adjusted to match historic data for the market under analysis

ES.2 Background to Circulating Nucleic Acids
This chapter reviews the historical developments that have excited researchers and clinicians alike illustrating the practical applications for elevated CNA levels for the detection of cancer and identifying the different categories or types of CNAs which are known to be present circulating in serum and plasma. This chapter also identifies the top molecular CNA characterisation techniques and technologies which are used to identify and measure CNAs.
Since the discovery of circulating nucleic acids in plasma in 1948, many diagnostic applications have emerged. For example, diagnostic and prognostic potentials of circulating tumor?derived DNA have been demonstrated for many types of cancer.

The parallel development of fetal?derived DNA detection in maternal plasma has opened up the possibility of non?invasive prenatal diagnosis and monitoring of many pregnancy?associated disorders. This is the subject of a distinct report also available from Veracity Health.

ES.3 Market Revenue Analysis: Non-invasive Prenatal Diagnostics
An analysis of the revenues and forecasts for the global non-invasive prenatal diagnostics (NIPD) market with a further more detailed analysis and forecast of the revenues for the global market sub-divided by major market sub-segments by geographic region and finally by selected country. This chapter also reviews the principle market drivers and restraints affecting and influencing the development of this market.

Please note that with the exception of North America each of the geographic regions analyzed include other remaining countries in these geographic regions. For the purposes of clarity within this report although these other individual countries in these geographic regions have been analyzed the market values and market shares have not been included. Should the reader require more detailed information about these countries the author of this report will be able to provide a customized report providing the additional information that would be required.

Veracity Health has determined that the global market was almost non-existent as products had not been available commercially in 2010.
By the year 2013 a number of commercially available products had entered the market driving the global market to an estimated value of $329.6 million. By using a proprietary
forecast spreadsheet which took into account the market variables it is predicted that by 2020 the market is set to grow to $2.61 billion (CAGR of 34.4%).

The valuation of the market reflects the changes to the economic, demographic and market variables which are affecting the value of the market. These include the:

- predicted relative decrease in product pricing as the market matures and as new lower priced products enter the market over the forecast period,
- Impact of the greater access and acceptability of non-invasive prenatal diagnostic testing in preference to the traditional methods such as amniocentesis.
- impact of the current global recession and its effect on the funding of national healthcare systems and specifically the diagnostics services within each national state.

ES.4 Market Share Analysis: Non-invasive Prenatal Diagnostics
Exhibit E.S.1 provides a summary of the market shares for the global non-invasive prenatal diagnostics (NIPD) market in 2013.
The global market is dominated by 5 major suppliers i.e. Sequenom, Inc, Ariosa Diagnostics, BGI Diagnostics (Division of BGI), Natera and Verinata Health (Illumina). These top 5 suppliers accounted for an estimated 92.9% of the global market in 2013 with the market leader Sequenom, Inc holding a 40.6% share of the market.
In addition a number of smaller companies such as, Ravgen, Cellular Research and Trovagene are emerging who could challenge the market leadership positions of the current leading suppliers.

ES.5 Company Profiles
This chapter provides the profiles of the leading 9 companies involved in the research and development, manufacture and marketing of devices which incorporate the technologies used for the detection of CNAs used in prenatal diagnostics. It provides a review of their historical development, key product areas including products in developments as well as short reviews of their key proprietary technologies.
Contents
Executive Summary
ES.1 Introduction to the Non-invasive Prenatal Diagnostics Market….. 7
ES.2 Background to Circulating Nucleic Acids.. 7
ES.3 Market Revenue Analysis: Non-invasive Prenatal Diagnostics. 8
ES.4 Market Share Analysis: Non-invasive Prenatal Diagnostics. 9
Exhibit E.S. 1: Global Market Share Analysis – Non-invasive Prenatal Diagnostic Products (2013)… 10
Exhibit E.S. 2: Global Market Share Analysis – Non-invasive Prenatal Diagnostic Products (2013)… 11
ES.5 Company Profiles….. 11
1.1 Background to the Report.. 13
1.2 Report Objectives and Deliverables… 14
1.3 Methodology….. 16
2.1 Introduction to Circulating Nucleic Acids (CNAs)…. 19
Exhibit 2.1: Major Developments in Understanding Nucleic Acids and their Cellular Roles 21
Exhibit 2.2: Circulating DNA Concentrations in Blood of Healthy Donors and Selected Cancer Patients 25
2.2 Categories of Circulating Nucleic Acids…. 26
2.2.1 Circulating Cell-Free DNA… 26
2.2.2 Circulating Extracellular DNA.. 27
2.2.3 RNA…. 28
2.2.3.1 microRNAs (miRNAs)…. 29
2.2.3.2 miRNA Mimics and Inhibitors.. 31
2.2.3.3 Small Interfering RNA (siRNA) 32
2.2.3.4 RNA Interference (RNAi)… 33
2.3 Circulating Nucleic Acids as a Diagnostic Tool… 33
2.3.1 Circulating DNA as a Biomarker of Cancer… 34
2.3.2 Use of Circulating DNA for Prenatal Diagnosis.. 35
2.3.3 Circulating RNA as a Biomarker of Cancer.. 39
Exhibit 2.3: Circulating Tumour-Associated miRNAs as potential biomarkers in Lung Cancer. 39
Exhibit 2.4: Circulating Tumour-Associated miRNAs as potential biomarkers in Breast Cancer…. 41
Exhibit 2.5: Circulating Tumour-Associated miRNAs as potential biomarkers in Prostate Cancer.. 42
Exhibit 2.6: Circulating Tumour-Associated miRNAs as potential biomarkers in Ovarian Cancer… 43
Exhibit 2.7: Circulating Tumour-Associated miRNAs as potential biomarkers in Bladder Cancer… 44
Exhibit 2.8: Circulating Tumour-Associated miRNAs as potential biomarkers in Pancreatic Cancer 45
Exhibit 2.9: Circulating Tumour-Associated miRNAs as potential biomarkers in Gastric Cancer….. 46
Exhibit 2.10: Circulating Tumour-Associated miRNAs as potential biomarkers in Liver Cancer. 46
Exhibit 2.11: Circulating Tumour-Associated miRNAs as potential biomarkers in Colo-Rectal Cancer ….. 47
Exhibit 2.12: Circulating Tumour-Associated miRNAs as potential biomarkers in Oral Cancer. 48
Exhibit 2.13: Circulating Tumour-Associated miRNAs as potential biomarkers in Esophageal Cancer …. 48
2.3.4 Circulating RNA in Pregnancy 49
2.4 Methods Used for the Detection of Circulating Nucleic Acids….. 49
Exhibit 2.14: Top molecular CNA Characterisation Techniques….. 50
Exhibit 2.15: Top molecular CNA Characterisation Techniques….. 51
3.1 Introduction 54
3.2 Market Dynamics… 55
3.2.1 Market Drivers. 55
3.2.1.1 Significant Advantages of Conventional Prenatal Screening and Diagnostic Methods….. 55
3.2.1.2 Significant Endorsement for NIPD….. 55
3.2.1.3 Recognised Benefits Associated with NIPD. 56
3.2.2 Market Restraints.. 57
3.2.2.1 Ethical Challenges in Providing Noninvasive Prenatal Diagnosis. 57
3.2.2.2 Specific Reimbursement and Accessibility Issues.. 58
3.2.2.3 Specific Identified Limitations of NIPD.. 59
3.3 Selected Non-invasive Prenatal Diagnostic Products… 60
Exhibit 3.1: Featured Non-invasive Prenatal Diagnostic Products. 60
3.4 Market Revenue Analysis 62
3.4.1 Global Market Revenue Analysis 62
3.4.2 Global Market Revenue Analysis by Geographic Region. 63
Exhibit 3.2: Global Market Revenue Forecast - Non-invasive Prenatal Diagnostic Products (2010 – 2020) ….. 66
Exhibit 3.3: Global Market Revenue Forecast - Non-invasive Prenatal Diagnostic Products (2010 – 2020) ….. 67
Exhibit 3.4: Market Revenue Forecast by Geographic Region - Non-invasive Prenatal Diagnostic Products (2010 – 2020) …. 68
Exhibit 3.5: Percentage Share of Global Market Revenue Forecast by Geographic Region - Non-invasive Prenatal Diagnostic Products (2010 – 2020) . 69
Exhibit 3.6: Percentage Share of Global Market Revenue Forecast by Geographic Region - Non-invasive Prenatal Diagnostic Products (2010 – 2020) . 70
3.4.3 Market Revenue Analysis by Selected Country .. 71
Exhibit 3.7: Market Revenue Forecast by Selected Countries - Non-invasive Prenatal Diagnostic Products (2010 – 2020) … 73
Exhibit 3.8: Market Revenue Forecast by Selected Countries - Non-invasive Prenatal Diagnostic Products (2010 – 2020) … 74
4.1 Market Share Analysis … 76
4.1.1 Global Market Share Analysis … 76
Exhibit 4.1: Global Market Share Analysis – Non-invasive Prenatal Diagnostic Products (2013).. 78
Exhibit 4.2: Global Market Share Analysis – Non-invasive Prenatal Diagnostic Products (2013).. 79
4.1.1 Market Share Analysis by Geographic Region …. 80
Exhibit 4.3: Market Share Analysis by Geographic Region (2013) .. 82
4.1.2 Market Share Analysis by Selected Country 83
Exhibit 4.4: Market Share Analysis by Selected Country - Non-invasive Prenatal Diagnostics (2013) … 85
5.1 Sequenom Inc 87
Exhibit 5.1: Sequenom, Inc., Revenues by Business Segment ($ millions) 2013-2011. 88
5.2 Ariosa Diagnostics ….. 90
5.3 Natera Inc 92
5.4 LifeCodexx AG 94
5.5 Verinata Health, Inc (Illumina, Inc) . 96
Exhibit 5.2: Illumina, Inc., Revenues by Business Segment ($ thousands) 2013-2011 . 97
5.6 Berry Genomics Co., Ltd . 102
5.7 BGI Diagnostics (Division of BGI) …. 103
5.8 CellScape .. 104
5.9 Kellbenx …. 105
Glossary of Acronyms . 106


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