Ascites Market Projected to Garner Healthy Growth, Stoked by the Expected Launch of Emerging Therapies During the Forecast Period (2021-2030), Asserts DelveInsight

LAS VEGAS, April 13, 2021 /PRNewswire/ -- DelveInsight's "Ascites Market" report provides a thorough comprehension of the Ascites, historical and forecasted epidemiology, and the Ascites market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Ascites market report also proffers an analysis of the current Ascites treatment algorithm/practice, market drivers, market barriers, and unmet medical needs. 

Some of the key takeaways of the Ascites Market Research Report 

• Tolvaptan, a novel aquaporin modulator, was made available in Japan in 2013 to treat patients with refractory Ascites due to cirrhosis. However, it is not approved in Japan for the Ascites treatment. 
• The current Ascites market has a high unmet need for approved and efficacious therapies. The treatment options for Ascites patients are limited and with very few therapies in the pipeline. 
• Ascites pipeline possesses potential drugs such BIV201 (Terlipressin), N-003 (Ambrisentan), and others in mid-stage developments to be approved shortly. 
• The major key players include BioVie, Noorik Biopharmaceuticals AG that hold the potential to drag a significant positive shift in Ascites market size.

For further information on Market Impact by Therapies, visit: Global Ascites Treatment Market 

Ascites is a condition in which fluid collects in spaces within the abdomen. The disease is common in patients with cirrhosis and usually develops when the liver is beginning to fail. The elevation of the pressure in the veins that run through the liver and a decrease in liver function due to the liver's scarring result in the fluid build-up.

Hepatic cirrhosis accounts for up to 80% of Ascites cases, and malignancies account for approximately 10%. The other types of ascites are categorised as cardiogenic, nephrogenic, infectious, and miscellaneous. 

According to DelveInsight's analysts, the total cases of Ascites due to cirrhosis were 240,730 cases in the 7MM in 2020. These cases are expected to increase during the study period of 2018–2030. 

The Global Ascites Market Report provides historical as well as forecasted epidemiological analysis segmented into: 

• Number of Ascites Cases due to Cirrhosis
• Number of Ascites Cases by Malignancies
• Severity-specific Cases of Ascites due to Cirrhosis 

Get a sample copy of this report: Ascites Market Size Landscape 

Ascites Treatment Market 

The principles behind the treatment of Ascites due to cirrhosis include diuretics, paracentesis, insertion of a transjugular intrahepatic portosystemic shunt (TIPS), and managing complications to Ascites such as spontaneous bacterial peritonitis (SBP). Mild and moderate Ascites due to liver cirrhosis can be treated with dietary sodium restriction, fluid restriction, use of diuretics, and use of therapeutic paracentesis.

Sodium restriction and diuretics are the mainstays of treatment for Ascites patients due to portal hypertension. Still, patients with low Serum Ascites Albumin Gradient (SAAG) Ascites do not respond well to these measures, except those with nephrotic syndrome.

Most often, patients will require water pills for Ascites treatment. Majorly used water pills are spironolactone (Aldactone) and/or furosemide (Lasix), and their dosages are appropriately adjusted. These water pills can cause blood electrolytes problems, and close monitoring by blood tests may be required. For patients unable to tolerate spironolactone due to painful gynecomastia, amiloride can be substituted, although it has a lower natriuretic effect than spironolactone. Eplerenone is a newer aldosterone antagonist used for heart failure treatment and is not associated with gynecomastia but has not been extensively researched yet to manage Ascites. Hydrochlorothiazide, in combination with furosemide, is not recommended due to combined hypokalemia. Torsemide and bumetanide have also been utilised in combination with spironolactone in the Ascites management, but they have not shown superiority over furosemide.

Among patients with cirrhosis and ascites, around 10-20% will develop refractory ascites. Once refractory ascites develop, one-year mortality is approximately 50%. Options for treatment include optimising medical management, serial large-volume paracentesis, transjugular intrahepatic portosystemic shunt (TIPS), peritoneovenous shunt, and liver transplantation.

Propranolol has shown to be associated with decreased survival in the setting of refractory ascites, and discontinuation should be considered. Oral Midodrine, an agent used to treat hypotension, increased mean arterial pressure, and improved survival in a pilot study in cirrhotic patients with refractory or recurrent ascites.

Liver transplantation is the ultimate treatment for cirrhosis and cirrhotic ascites as the refractory ascites portends a particularly poor prognosis.

The current Ascites market has a high unmet need for approved and efficacious therapies. The treatment options for Ascites patients are limited and with very few therapies in the pipeline. 

Ascites Emerging Therapies Along with Key Players

• BIV201 (Terlipressin): BioVie
• N-003 (Ambrisentan): Noorik Biopharmaceuticals AG 

And several others.

Final comments on Ascites Market Growth 

Ascites Market Drivers 

• Increasing patient population - The rise in the patient population of underlying conditions of Ascites such as liver cirrhosis, alcoholism, kidney or heart failure, malignancy, and others might contribute to an increase in the Ascites patient population. 
• Emerging therapies in the pipeline - Limited approved, and emerging therapies in the pipeline offer an excellent opportunity for the investment and development of novel therapies. 
• Unmet needs - Most of the therapies are developed to be administered frequently. Hence medications with better safety, effectiveness, and low treatment duration are the current unmet need of the Ascites market. 
• Rising awareness - The increasing healthcare activities and campaigns regarding the necessity to address ascites are aiding the market. 

Ascites Market Barriers 

• Complications associated with ascites - The probability of occurrence of refractory ascites is non-negligible.
• No curative/preventive therapy - Available pharmacological therapies provide only symptomatic relief. 
• Delayed diagnosis - The lack of understanding of pathophysiology and clinical relevance may represent a missed opportunity to make the correct diagnosis, which can potentially lead to a delayed diagnosis. 
• Strict pricing and reimbursement policies. 

Scope of the Ascites Market Insight Report 

• Geography Covered: 7MM - The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan.
• Study Period (2018-2030): 3-year historical and 10-year forecasted analysis (2021-2030).
• Ascites Markets Segmentation: By Geographies and By Ascites Therapies (Historical and Forecasted, Current and Upcoming) 
• Dominant Market Companies investigating its candidates for Ascites: BioVie, Noorik Biopharmaceuticals AG, and several others.
• Analysis: Comparative and conjoint analysis of emerging therapies. 
• Case Studies
• KOL's Views
• Analyst's View

Request for a Webex demo of the report @ Ascites Treatment Market Size

Table of Contents 

Browse full report with detailed TOC with charts, figures, tables @ Ascites Treatment Market Report

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SOURCE DelveInsight Business Research, LLP