Avant Technologies and Austrianova Advancing α-Klotho Cell Therapy as Mayo Clinic Study Links Low α-Klotho Levels to Poor Cardiovascular Survival

LAS VEGAS, Dec. 9, 2025 /PRNewswire/ -- Avant Technologies, Inc. (OTCQB: AVAI) ("Avant" or the "Company"), an emerging biotechnology company focused on developing cell-based therapies for diabetes and age-related disorders, today announced a newly published study from the Mayo Clinic reinforces the critical role of the "longevity protein" α-Klotho in vascular health and aging. The research, appearing in the Journal of the American Heart Association, demonstrates a strong association between declining α-Klotho levels and arterial stiffness, endothelial dysfunction, vascular calcification, and significantly reduced patient survival.

The 148-patient study explained:

• Low α-Klotho levels are associated with vascular calcification not only in patients with chronic kidney disease but also in the general population without CKD, highlighting its role in vascular aging.
  
  
• Low α-Klotho levels are independently associated with increased mortality, regardless of age, sex, and comorbidities, suggesting that Klotho could serve as a prognostic biomarker for long-term survival.

And the study's authors concluded, "Further research is needed to unravel the mechanisms through which α-Klotho influences vascular calcification and aging, in order to identify targeted treatments that could prevent or reverse these processes."

Klothonova, a joint venture company established between Austrianova and Avant, is developing a cutting-edge cell-based therapy designed to address this need by sustainably restoring circulating α-Klotho levels in patients.

The therapy utilizes genetically modified human cells that continuously produce and secrete α-Klotho. These cells are encapsulated using Austrianova's clinically validated Cell-in-a-Box^® technology, which protects the implanted cells from immune rejection while allowing long-term protein delivery.

Dr. Brian Salmons, CEO of Austrianova, said of the study, "This landmark publication by Prof. Amir Lerman's team at Mayo Clinic provides compelling clinical evidence linking lower α-Klotho levels to cardiovascular disease progression and mortality. By encapsulating α-Klotho-producing cells with our proven Cell-in-a-Box^® platform—already demonstrated as safe and effective in human cancer trials—we believe we can meaningfully elevate systemic α-Klotho levels and positively impact cardiovascular disease and other age-related conditions associated with Klotho deficiency."

Chris Winter, CEO of Avant Technologies, added, "An ever-growing body of scientific literature, including this new Mayo Clinic study, confirms α-Klotho as a master regulator of aging and longevity. The age-related decline in α-Klotho is implicated in a wide range of chronic diseases that appear reversible when Klotho levels are restored. Our encapsulated cell therapy approach has the potential to be a true game-changer—not only for cardiovascular health but for healthy longevity in general."

The study's authors also expressed that low Klotho levels are linked to diabetes, peripheral arterial disease, and other age-related conditions. These conditions often precede more severe cardiovascular diseases, highlighting the importance of Klotho in maintaining vascular integrity and function. Furthermore, Klotho is recognized for its antiaging properties.

Reference: https://www.ahajournals.org/doi/10.1161/JAHA.125.043654

About Avant Technologies
Avant Technologies, Inc. is an emerging biotechnology company focused on identifying genetically modified cells lines, and through joint venture and licensing agreements developing innovative cell-based therapies.

About Klothonova
Klothonova is a 50/50 joint venture between Avant Technologies and Austrianova, focused on developing novel cell-based therapies utilizing the Klotho protein for age-related conditions. Headquartered in Las Vegas, Nevada, Klothonova combines expertise in genetic engineering, cell encapsulation, and therapeutic delivery to pioneer sustainable, long-acting treatments.

About Austrianova
Austrianova, based in Singapore, is a leading biotechnology company specializing in clinically proven cell encapsulation, GMP-grade cell products, and cell line development, backed by over 50 peer-reviewed publications and partnerships with global biotech companies.

More information about Avant can be found at https://avanttechnologies.com

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SOURCE Avant Technologies Inc.