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BOA™ Biomedical's GARNET™ therapeutic product begins First in Human clinical trial

(PRNewsfoto/BOA Biomedical)

News provided by

BOA Biomedical

Mar 18, 2021, 09:45 ET

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CAMBRIDGE, Mass., March 18, 2021 /PRNewswire/ -- BOA Biomedical, a Miraki™ Innovation company, focused on rapidly diagnosing and treating some of the world's deadliest infectious diseases has announced that the company will begin its First in Human clinical trial for GARNET. GARNET is an extracorporeal blood cleansing therapeutic capable of removing a significant number of pathogens and their toxic inflammation-triggering debris directly from a patient's blood. BOA's platform technology has both diagnostic and therapeutic applications and has demonstrated the ability to capture more than 100 clinically relevant bacteria, fungi, parasites, toxins and viruses, including SARS-CoV-2. Infectious diseases are a leading cause of death worldwide. COVID-19 has already claimed the lives of over 500,000 U.S. citizens and over 2.4 million worldwide. This major milestone advances BOA's mission of revolutionizing the fight against infectious disease and sepsis, by providing governments, nurses and doctors with tools and technology to save lives.

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The GARNET™ extracorporeal blood cleansing therapeutic capable of removing a significant number of pathogens and their toxic inflammation-triggering debris directly from a patient's blood.
The GARNET™ extracorporeal blood cleansing therapeutic capable of removing a significant number of pathogens and their toxic inflammation-triggering debris directly from a patient's blood.
Christopher Velis, Founder and Executive Chairman of Miraki™ Innovation and BOA™ Biomedical with the GARNET™ extracorporeal blood cleansing therapeutic.
Christopher Velis, Founder and Executive Chairman of Miraki™ Innovation and BOA™ Biomedical with the GARNET™ extracorporeal blood cleansing therapeutic.

When it comes to infectious disease, knowledge is power and speed is paramount. For each hour of delay in treating an advanced case of sepsis, fatality rates increase by up to 8%. BOA's technology has the potential to effectively manage infectious disease throughout the patient journey—from diagnosis, to tracking to treatment. GARNET also addresses the growing emergence of antibiotic-resistant infection, a significant limitation of existing therapies, and is intended to serve as a medical countermeasure capable of responding to any infectious outbreak, even when the pathogen is unknown.

BOA's extracorporeal blood filtration technology was developed at the Wyss Institute for Biologically Inspired Engineering at Harvard University and was funded by the U.S. Department of Defense (DOD) and Miraki Innovation. "Our team has developed this technology to provide a broad therapeutic capability to treat bloodstream infections and prevent sepsis that can be used in patients even when the pathogen cannot be identified or is resistant to antibiotics. It is extremely exciting and gratifying to see the enormous progress BOA has made in rapidly moving it into the clinic," states Donald Ingber M.D., Ph.D., Founding Director of the Wyss Institute, faculty member at Harvard School of Medicine and Engineering, a scientific founder of BOA and a member of its board of directors.

BOA has obtained approval from the U.S. FDA to conduct an Early Feasibility Study under an Investigational Device Exemption (IDE) for GARNET.  This prospective, multi-center, single-arm study will initially enroll 15 subjects at up to five sites. GARNET is intended to be used in subjects with confirmed or suspected bloodstream infection. Nisha Varma, COO of BOA says "This clinical experience can also be extended for use in patients with SARS-CoV-2".  

According to Christopher Velis, Founder and Executive Chairman of Miraki Innovation and BOA Biomedical "In the U.S., every 20 seconds a patient is diagnosed with sepsis and $24 billion per year is spent on treating this life-threatening disease.  BOA's aim is to put a stop to this. Our goal is to get the best minds in infectious disease to bring revolutionary, life-saving technologies to patients as soon as possible. This medical countermeasure aspires to intervene in pandemic outbreaks, bioterrorism and military operations". Christopher also founded Auris Health in 2007, which was acquired in Feb 2019 by Johnson & Johnson, valued at $5.75 billion (inclusive of milestone payments).

About BOA Biomedical
BOA Biomedical is a Miraki Innovation focused on infectious disease. Our mission is to provide governments, nurses, doctors and patients with innovative tools to fight the world's most deadly infectious diseases and their outcomes including sepsis, hospital-acquired infections, antibiotic resistance, pandemic infections, pathogenic outbreaks, and the threat of bioterrorism.  We have an exclusive global license to technology from the Wyss Institute at Harvard University.  BOA's platform manages infectious disease throughout the patient journey from diagnosis to tracking to treatment.

About Miraki
Miraki Innovation is a technology development venture capital firm that identifies global healthcare problems. We source technology and our funds build portfolio companies needed to solve these pressing needs. Our investment strategy balances entrepreneurial creativity with strict, unbiased discipline. We blend the experience of a seasoned venture capital firm with the ingenuity of a highly-efficient and agile management model. Our teams are diverse, skilled and dedicated. We work because we are driven to solve the world's most pressing health problems. Our values of integrity, teamwork and constant improvement enable us to build thriving portfolio companies.

Contact:

Alan Weinberg


Director of Marketing


(617) 963-8990


[email protected]  

SOURCE BOA Biomedical

Related Links

http://www.boabiomedical.com

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