Caris Life Sciences to Present Six Oncology Studies Utilizing Proprietary Multimodal Data at the AACR Annual Meeting 2026

IRVING, Texas, March 25, 2026 /PRNewswire/ -- Caris Life Sciences^® (NASDAQ: CAI), a leading, patient-centric, next-generation AI TechBio company and precision medicine pioneer, today announced that the Caris Precision Oncology Alliance^® (Caris POA^®) and collaborators from leading cancer centers, will collectively present six studies at the 2026 American Association for Cancer Research (AACR) Annual Meeting in San Diego, California to be held April 17-22, 2026.

These studies leveraged Caris' robust multimodal database, which integrates Whole Exome Sequencing (WES), Whole Transcriptome Sequencing (WTS), immunohistochemistry (IHC) and real world clinical data, to generate clinically meaningful insights across multiple tumor types. This research reflects Caris' commitment to advancing precision oncology through deep molecular interrogation. The studies focused on breast, prostate, lung and colorectal cancers represent a collaborative effort between Caris and leading cancer centers and institutions, underscoring the power of large‑scale, real world molecular evidence to accelerate discovery and improve patient outcomes.

"These studies demonstrate the transformative potential of multimodal molecular data to uncover clinically meaningful patterns that would otherwise remain hidden," said James Hamrick, MD, MPH, Chairman of the Caris POA. "By combining deep genomic profiling with real world clinical evidence, Caris and its collaborators are generating insights that can directly inform treatment decisions and accelerate the development of more effective therapies for patients."

Posters Include:

• Spatially resolved tumor-cell MHC class II shapes adaptive immunity and therapeutic response in triple-negative breast cancer
  Session: Spatial Proteomics and Transcriptomics 1
  Sunday, April 19, 2026, 2:00 PM – 5:00 PM PST
  Poster #: 1200/1
  Location: Poster section 47
  
  
• Prognostic and predictive effects of TP53 co-mutations and RET fusion partners in RET-rearranged advanced NSCLC
  Session: Biomarkers Predictive of Therapeutic Benefit 3
  Monday, April 20, 2026, 9:00 AM – 12:00 PM PST
  Poster #: 2434/4
  Location: Poster section 40
  
  
• AR copy number amplification and AR/KLK3 expression patterns reveal mechanisms of AR signaling inhibitor (ARSI) resistance and highlight the need for AR-directed therapeutic innovation in metastatic castration resistance prostate cancer (mCRPC)
  Session: Molecular Targeted Therapy
  Monday, April 20, 2026, 2:00 PM – 5:00 PM PST
  Poster #: 3910/16
  Location: Poster section 47
  
  
• cBioPortal for cancer genomics
  Session: AACR Project GENIE: Genomic Characterization
  Tuesday, April 21, 2026, 9:00 AM – 12:00 PM PST
  Poster #: 4097/2
  Location: Poster section 1
  
  
• Distinct KRAS mutation codons differentially associate with microsatellite instability in colorectal carcinoma
  Session: Precision Oncology and Real World Data
  Tuesday, April 21, 2026, 9:00 AM – 12:00 PM PST
  Poster #: 5336/4
  Location: Poster section 46
  
  
• MCM2 and the origin licensing complex: A putative node of ER+/HER2- breast cancer therapy resistance
  Session: Real World Data to Provide Real World Evidence
  Tuesday, April 21, 2026, 2:00 PM – 5:00 PM PST
  Poster #: 6647/16
  Location: Poster section 47

Research highlights will be available onsite at Caris' booth #1423. The full abstracts will be available on the Caris website following the presentations.

About Caris Life Sciences 
Caris Life Sciences^® (Caris) is a leading, patient-centric, next-generation AI TechBio company and precision medicine pioneer actively developing and commercializing innovative solutions to transform healthcare. Through comprehensive molecular profiling (Whole Genome, Whole Exome and Whole Transcriptome Sequencing), advanced AI and machine learning, Caris has created the large-scale, multimodal clinico-genomic database and computing capability needed to analyze and further unravel the molecular complexity of disease. This convergence of next-generation sequencing, AI and machine learning technologies and high-performance computing provides a differentiated platform for developing the latest generation of advanced precision medicine diagnostic solutions for early detection, diagnosis, monitoring, therapy selection and drug development.

Caris was founded with a vision to realize the potential of precision medicine to improve the human condition. Headquartered in Irving, Texas, Caris has offices in Phoenix, New York, Cambridge (MA), Tokyo, Japan and Basel, Switzerland. Caris or its distributor partners provide services in the U.S. and other international markets.

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