CIT and Biomodels Announce Alliance

Skills in providing efficacy models combined with GLP toxicology know-how will provide clients with seamless development services

Dec 17, 2010, 12:30 ET from Biomodels, LLC

EVREUX, France and WATERTOWN, Mass., Dec. 17, 2010 /PRNewswire/ -- CIT, the preclinical drug safety CRO based outside Paris, and Biomodels, the Boston-based service company offering tailor-made preclinical efficacy models, announce today the signature of an alliance agreement. Under the terms of this transatlantic agreement, the two companies will develop packages of integrated services covering the early development of candidate drugs and their passage into the development phase.

The synergy derived from this alliance will enable the two companies to provide their clients with a comprehensive and seamless program of pre-clinical drug development, as well as new high-content testing approaches. Financial details of the agreement were not disclosed.

"CIT is very excited about working with Biomodels especially because of its ability to generate customized preclinical efficacy models," said Dr Roy Forster, CSO of CIT. "This opens the way to unique approaches that permit rigorous profiling of the clinical potential of candidate drugs. Working hand in hand with Biomodels, we will further enrich our understanding of the efficacy and best therapeutic deployment of new drugs and bring these benefits to our clients."

"Biomodels too is excited about the prospects offered by working with CIT and being able to share in its wide range of services," said Professor Stephen Sonis, chief medical officer of Biomodels. "CIT goes well beyond just regulatory toxicology, and has been developing services in biomarkers, multiplex analyses, toxicogenomics and integrated safety pharmacology measurements."

The two companies will begin their relationship with integrated packages of services that offer clients a seamless program of preclinical drug development. The next step will be to develop high content testing approaches that will provide significant added value for clients.

"CIT's US affiliate, CITox Inc, is responsible for setting up this agreement, a clear affirmation of CIT's presence in the US and of our proximity to US clients," said Sophie Baratte, CEO of CIT. "Through this alliance, CIT and Biomodels are offering early testing capabilities in the US that we will transfer smoothly into preclinical development services in our French facility."

About Biomodels

Biomodels (, a preclinical drug research organization founded in 1997, develops and conducts predictive translational studies for biotechnology and pharmaceutical companies, particularly in the areas of cancer, cancer supportive care, radiation therapy, and inflammatory diseases. The company specializes in (non-GLP) efficacy studies that optimize dose, schedule and define mechanism of action. The company also has particular expertise in modeling inflammatory diseases, including those conditions affecting the gastrointestinal tract.

About CIT

CIT ( is a science-driven, independent, non-clinical contract research organization (CRO) specialized in safety and health research. Founded in 1969, CIT has carried out a vast number of projects for international companies on human and veterinary pharmaceuticals, biotechnology, chemicals, agrochemicals and consumer products. It has contributed to many product registrations around the world. With a staff of 360, CIT offers a full range of research in general toxicology, reproductive toxicology, carcinogenicity, pharmacokinetics and safety pharmacology. The company also carries out research into genetic toxicology, in vitro testing and toxicogenomics.  Its 20,000-square metre (215,000 sq ft) facilities located in Normandy, one hour from Paris, France, house all principal laboratory animal species to the highest standards. Laboratory facilities include analytical chemistry and bioanalysis, clinical pathology, genomics and histology. Support facilities include archives and plant buildings. The company is GLP and AAALAC certified. More than half the company's business comes from international customers. Overall, 80 per cent of revenues are in the pharmaceutical and biotechnology sector. Biotechnology and start-up companies alone account for 50 per cent. The company has a world-class team of top-level management in scientific, financial and business activities.

SOURCE Biomodels, LLC