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deCODE genetics/Amgen : Une nouvelle étude explore le rôle de l'IMC dans le risque de maladie
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deCODE genetics logo with Amgen

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deCODE genetics

Nov 12, 2024, 09:03 ET

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REYKJAVIK, Islande, 12 novembre 2024 /PRNewswire/ -- Une nouvelle étude  de deCODE genetics/Amgen souligne l'importance de l'IMC dans la pathogenèse des maladies, suggérant que la réduction de l'IMC pourrait à elle seule diminuer le risque de plusieurs maladies.

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Kari Stefansson and Gudmundur Einarsson, scientists at deCODE genetics and authors on the paper, discuss a new paper in Nature Communications that sheds light on how Body Mass Index (BMI) influences the risk of various diseases that are comorbid with obesity.
Kari Stefansson and Gudmundur Einarsson, scientists at deCODE genetics and authors on the paper, discuss a new paper in Nature Communications that sheds light on how Body Mass Index (BMI) influences the risk of various diseases that are comorbid with obesity.

Des scientifiques de deCODE genetics, filiale d'Amgen, ont publié aujourd'hui une étude dans Nature Communications qui met en lumière la manière dont l'indice de masse corporelle (IMC) influence le risque de diverses maladies comorbides avec l'obésité. L'étude, qui a utilisé des données génétiques provenant d'Islande et de la UK Biobank, a cherché à déterminer si le risque de maladie associé aux variants de séquence liés à l'IMC s'expliquait entièrement ou partiellement par leur effet sur l'IMC.

Les résultats ont montré que pour certaines pathologies, telles que la stéatose hépatique, l'intolérance au glucose et l'arthroplastie du genou, le lien génétique avec la maladie disparaissait lorsque l'IMC était pris en compte. Pour d'autres pathologies, comme le diabète de type 2, l'insuffisance cardiaque et les accidents vasculaires cérébraux, les effets ont été largement réduits mais pas entièrement expliqués par l'IMC.

L'étude a révélé des tendances similaires chez les hommes et les femmes, bien qu'il y ait quelques différences, en particulier pour l'infarctus du myocarde (crise cardiaque), ce qui suggère que le sexe peut jouer un rôle dans l'influence de l'IMC sur le risque de maladie. Les scientifiques ont également noté que d'autres facteurs, tels que l'évolution de l'IMC au fil du temps plutôt que l'IMC mesuré à un moment donné ou d'autres facteurs fortement corrélés à l'IMC, pourraient expliquer une partie du risque restant.

Cette recherche met en évidence l'importance de l'IMC dans la pathogenèse des maladies qui sont plus fréquentes chez les personnes obèses que chez les autres , suggérant que la simple réduction de l'IMC pourrait diminuer le risque de ces maladies.

Lien vers la vidéo : https://vimeo.com/1023255678/5728d8badb

Vidéo - https://mma.prnewswire.com/media/2554046/Kari_Gudmundur_Video.mp4
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