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deCODE genetics/Amgen: Neue Studie erforscht die Rolle des BMI beim Krankheitsrisiko
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deCODE genetics Amgen Logo

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deCODE genetics

Nov 12, 2024, 08:53 ET

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REYKJAVIK, Island, 12. November 2024 /PRNewswire/ -- Eine neue Studie von deCODE genetics/Amgen unterstreicht die Bedeutung des BMI bei der Krankheitsentstehung und deutet darauf hin, dass eine Verringerung des BMI allein das Risiko für mehrere Krankheiten senken könnte.

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Kari Stefansson and Gudmundur Einarsson, scientists at deCODE genetics and authors on the paper, discuss a new paper in Nature Communications that sheds light on how Body Mass Index (BMI) influences the risk of various diseases that are comorbid with obesity.
Kari Stefansson and Gudmundur Einarsson, scientists at deCODE genetics and authors on the paper, discuss a new paper in Nature Communications that sheds light on how Body Mass Index (BMI) influences the risk of various diseases that are comorbid with obesity.

Wissenschaftler von deCODE genetics, einer Tochtergesellschaft von Amgen, haben heute in Nature Communications eine Studie veröffentlicht, die Aufschluss darüber gibt, wie der Body-Mass-Index (BMI) das Risiko für verschiedene Krankheiten beeinflusst, die mit Übergewicht einhergehen. In der Studie, für die genetische Daten aus Island und der britischen Biobank verwendet wurden, wurde untersucht, ob das mit BMI-bezogenen Sequenzvarianten verbundene Krankheitsrisiko vollständig oder teilweise durch ihre Auswirkungen auf den BMI erklärt wird.

Die Ergebnisse zeigten, dass bei einigen Erkrankungen, wie z. B. Fettleber, Glukoseintoleranz und Kniegelenkersatz, der genetische Zusammenhang mit der Krankheit verschwindet, wenn der BMI berücksichtigt wird. Bei anderen Erkrankungen, wie Typ-2-Diabetes, Herzinsuffizienz und Schlaganfall, wurden die Auswirkungen weitgehend reduziert, aber nicht vollständig durch den BMI erklärt.

Die Studie ergab ähnliche Muster bei Männern und Frauen, obwohl es einige Unterschiede gab, insbesondere bei Herzinfarkten, was darauf hindeutet, dass das Geschlecht eine Rolle dabei spielen könnte, wie der BMI das Krankheitsrisiko beeinflusst. Die Wissenschaftler wiesen auch darauf hin, dass andere Faktoren, wie z. B. Veränderungen des BMI im Laufe der Zeit anstelle des zu einem bestimmten Zeitpunkt gemessenen BMI oder andere stark mit dem BMI korrelierende Faktoren, einen Teil des verbleibenden Risikos erklären könnten.

Diese Forschung unterstreicht die Bedeutung des BMI bei der Entstehung von Krankheiten, die bei fettleibigen Menschen häufiger vorkommen als bei anderen, was darauf hindeutet, dass allein die Senkung des BMI das Risiko für diese Krankheiten senken könnte.

Link zum Video: https://vimeo.com/1023255678/5728d8badb

Video - https://mma.prnewswire.com/media/2554046/Kari_Gudmundur_Video.mp4
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