WALTHAM, Mass., June 2 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, for the treatment of HIV, Gilead and Tibotec (a wholly owned subsidiary of Johnson & Johnson) remain on track to launch three novel treatment options in the next two years – Gilead's Quad (a four drug, one pill, once-daily, regimen), Tibotec's rilpivirine and Gilead/Tibotec's rilpivirine/emtricitabine/tenofovir fixed-dose combination product. Together, these products have the potential for combined peak-year sales in excess of $5 billion in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan.
The Pharmacor 2010 findings from the topic entitled Human Immunodeficiency Virus reveal that, through 2018, Gilead's Quad will earn peak-year sales of up to $2.5 billion and Gilead/Tibotec's rilpivirine/emtricitabine/tenofovir will earn peak-year sales of up to $3 billion. Robust uptake of these agents will be driven by their favorable safety and efficacy profiles and convenient dosing which make them ideal products for treatment-naive patients -- the most lucrative segment of the HIV market.
"Gilead and Tibotec continue to make strong progress with their HIV programs. Gilead will bring the first ever quadruple fixed-dosed therapy -- Quad -- to the market and Tibotec will bring a novel NNRTI -- rilpivirine -- to the market by 2011," said Decision Resources Therapeutic Area Director Danielle Drayton, Ph.D. "Additionally, following approval of rilpivirine as a stand-alone therapy, Gilead plans to seek approval for a fixed-dose combination of Tibotec's rilpivirine plus Gilead's Truvada as a follow-on to Gilead's blockbuster Atripla."
The Pharmacor 2010 findings also reveal that, owing to the widespread availability of HIV therapies that are effective and relatively well tolerated, the largest commercial opportunities in this market lie in the development of agents that offer enhanced convenience. Such therapies include coformulations that minimize the number of pills and frequency of dosing, especially therapies that target the large treatment-naive population. Additionally, agents with reduced long-term toxicities can differentiate themselves in the market.
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