GenomeDx's Decipher Prostate Cancer Test is Significant Predictor of Metastasis in Patients With Detectable PSA Following Treatment with Radiation after Prostate Surgery, According to Study Presented at ASCO 2015 Annual Meeting
Decipher test results show potential utility in determining benefit of hormone therapy and timing of salvage radiation therapy
CHICAGO, May 30, 2015 /PRNewswire/ -- GenomeDx Biosciences today announced that data presented at the 2015 American Society of Clinical Oncology Annual Meeting demonstrate that the Decipher® Prostate Cancer Classifier is a significant predictor of metastasis in patients treated with postoperative salvage radiation therapy. Importantly, patients with a low Decipher score had excellent outcomes overall, independent of whether they received early or late salvage radiation, and with or without concurrent hormone therapy. In contrast, patients with a high Decipher score had comparatively worse outcomes, although they had improved metastasis-free survival with early salvage radiation.
In the study led by investigators at Thomas Jefferson University and the Durham VA, which evaluated 170 patients who received radiation therapy for a postoperative rising PSA or biochemical recurrence, only 2.7% of men with a low Decipher score had metastatic disease within 5 years. Metastasis occurred in 8.4% of men with an intermediate Decipher score and 33.1% of men who had a high Decipher score. While, in the lower Decipher risk group there were no significant differences in metastasis incidence, in the men with higher Decipher risk who received early salvage radiation had only 7.8% metastasis incidence compared to 28.7% for men who received late salvage radiation (p=0.031). The study, titled "Validation of a genomic classifier for prediction of metastasis following postoperative salvage radiation therapy", was presented today by Adam Dicker, M.D., Ph.D., Chair of Radiation Oncology at the Sidney Kimmel Cancer Center at Thomas Jefferson University.
"Based on these data, we believe that this predictive technology, using precision medicine, can help us tailor treatment approaches to fit an individual patient's risk," Dr. Dicker said. "This may mean avoiding concurrent hormone therapy and delaying radiation for patients with a low Decipher score, and recommending earlier radiation and intensification of therapy for patients with higher Decipher scores."
Also highlighted today, Ashley Ross, M.D., of The Brady Urologic Institute at Johns Hopkins School of Medicine, presented data from a study titled "Tissue Based Genomics Augment Post-Prostatectomy Risk Stratification in a Natural History Cohort". The study showed that a high Decipher score was predictive of metastasis after radical prostatectomy in a cohort of men that received no postoperative therapy prior to metastatic onset. Decipher was able to predict metastasis free survival at 10 years in this 'natural history' cohort of 260 intermediate and high-risk men. In the study, the cumulative incidence of metastasis at 10 years was significantly higher for those men with a high Decipher score (47%) versus those with low scores (12%). Two additional abstracts were accepted for publication in the 2015 ASCO Annual Meeting Proceedings.
The commercially available Decipher Prostate Cancer Classifier is covered by Medicare and evaluates 22 genomic markers to accurately & independently predict metastatic onset after radical prostatectomy for patients with adverse pathology. The Decipher test was developed by interrogating billions of genomic data points collected from clinical studies published in over 20 peer-reviewed articles.
About Decipher®
The Decipher® Prostate Cancer Classifier is a highly validated and commercially available genomic test for men with intermediate and high risk prostate cancer. Decipher predicts cancer aggressiveness by looking for a unique genomic signature comprised of a validated series of biomarkers associated with metastatic disease. Adding truly unique information to the treatment decision-making process, Decipher generates a risk result that is completely independent and distinct from PSA, Gleason score and other clinical risk factors. Clinical studies from leading cancer centers published in over a dozen medical journals demonstrate that Decipher can accurately predict metastatic disease, which men may benefit from radiation therapy following prostate surgery, and can lead to significant cost-savings for healthcare systems. Decipher was developed in partnership with the Mayo Clinic.
Decipher is covered by Medicare and multiple private insurance plans and is available to eligible US patients through their physicians.
Learn more at: www.DecipherTest.com and follow Decipher on Twitter at @DecipherTest and on Facebook.
About GenomeDx Biosciences
GenomeDx Biosciences is focused on transforming cancer patient care by putting usable genomic information in the hands of patients and their physicians. GenomeDx is developing and commercializing Decipher®, a highly validated genomic test for predicting metastatic disease in men with prostate cancer. In partnership with leading medical centers, the company has assembled the largest genomic catalogue of prostate cancer tumors in the world, representing billions of data points and more than 30 years of prostate cancer clinical experience. Using advanced cloud-based bioinformatics, GenomeDx mines the genomic data to develop proprietary tests that address key clinical questions in cancer patient management. GenomeDx has partnered to share genomic data with leading clinician-scientists worldwide to collaboratively enrich the knowledge and understanding of urologic cancers for the goal of improving global cancer patient care. GenomeDx is based in San Diego, California and Vancouver, British Columbia.
Learn more at www.genomedx.com and follow us on Twitter at @GenomeDx, Facebook, LinkedIn and YouTube.
Media Contact:
Ian Stone
Canale Communications
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SOURCE GenomeDx Biosciences
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