Global Platform Launches to Transform Bipolar Disorder Research and Care

BD² commits to finding answers  for the 40 million individuals with bipolar disorder and those not yet diagnosed

WASHINGTON, Sept. 12, 2022 /PRNewswire/ -- Today, three family philanthropies joined with the Milken Institute to commit $150 million to launch BD²: Breakthrough Discoveries for thriving with Bipolar Disorder.

Bipolar disorder is a serious mental health condition with dramatic and often unpredictable shifts in mood, energy, activity, and cognition, affecting at least 40 million people worldwide.

While funding for mental health has increased overall, federal funding for research related exclusively to bipolar disorder has decreased by 50% over the past 10 years. As the largest private investment focused on the study of bipolar disorder, BD² provides an unprecedented opportunity to identify breakthroughs in scientific understanding that create new interventions so that everyone with bipolar disorder can thrive.

"For far too long, bipolar disorder has lacked funding and collaboration to identify scientific advancements and treatment improvements," said Kent Dauten, co-founder and chairman of Keystone Capital and one of three families launching the effort. "BD² is a commitment to the 40 million people living with bipolar disorder and their loved ones."

The Baszucki, Dauten, and Brin families united with the Milken Institute to create BD² to advance discoveries for families like theirs. David Baszucki, founder and CEO of Roblox, and Jan Ellison Baszucki, best selling author and mental health advocate, experienced the challenges of a mental health crisis firsthand in 2016 when their son was diagnosed with bipolar disorder at age 19, and created the Baszucki Brain Research Fund to support bipolar disorder focused research. Kent Dauten and his wife, Liz, have supported bipolar disorder research extensively after two of their four children were diagnosed as teenagers. They founded the Dauten Family Center for Bipolar Treatment Innovation at Massachusetts General Hospital. Google co-founder Sergey Brin supports an array of health research initiatives aimed at breakthroughs for Parkinson's, bipolar disorder, and other neurological conditions through the Sergey Brin Family Foundation. As a think tank and global convener, the Milken Institute is playing a leadership role in BD², designing its structure and overseeing grantmaking so that investments make a transformational impact.

"BD² is unique in its platform-based, integrated approach to innovation in both science and clinical care," said Jan Ellison Baszucki, who together with her husband, David Baszucki, is providing initial funding. "By bringing together researchers, clinicians, funders, and those with lived experience, we hope BD² will deliver innovative treatments like those that helped our son recover his health."

"BD² presents an opportunity to apply experience and resources directly to bipolar research to advance our knowledge and ultimately improve diagnosis and care," said  Cara Altimus, PhD, BD²'s managing director and senior director at the Milken Institute. "Together, we will accelerate discoveries for bipolar disorder and demonstrate that our approach to collaborative funding and integrated research is a new model for biomedical research."

Taking learnings from the development of Aligning Science Across Parkinson's (ASAP), a core mission of BD² is to provide unparalleled access to breakthrough insights on bipolar disorder through four unique programs. The BD² Discovery Grants, Brain Omics, Genetics Platforms, and the Integrated Network are designed to share data, methods, and resources across initiatives and the bipolar disorder research community.

• The BD² Discovery Grants will fund multidisciplinary teams of scientists and clinicians to develop targeted and innovative research proposals that examine the genetic, molecular, cellular, circuit, or behavioral mechanisms of bipolar disorder.
• The Brain Omics Platform will provide state-of-the-art multi omics to understand neural and non-neural changes in bipolar disorder on a molecular scale, an approach used in other brain diseases but is unprecedented in bipolar disorder studies.
• The BD² Genetics Platform will collect and genotype a large number of samples from individuals with diverse backgrounds who experience bipolar disorder to close a fundamental gap in science's understanding of the genetic mechanisms of bipolar disorder.
• The BD² Integrated Network is a collaborative longitudinal study with an initial focus on people living with bipolar I. The study design and infrastructure prioritize rapid implementation of research findings to improve treatment for all those living with bipolar disorder."

About BD²

Through an integrated, collaborative approach, BD²: Breakthrough Discoveries for thriving with Bipolar Disorder will address knowledge gaps in the basic disease mechanisms of bipolar disorder as well as factors influencing clinical approaches and outcomes. This initial $150 million effort provides an unprecedented opportunity to improve the lives of people with bipolar disorder and those yet to be diagnosed.

About the Milken Institute

The Milken Institute is a nonprofit, nonpartisan think tank focused on accelerating measurable progress on the path to a meaningful life. With a focus on financial, physical, mental, and environmental health, we bring together the best ideas and innovative resourcing to develop blueprints for tackling some of our most critical global issues through the lens of what's pressing now and what's coming next.

About the Milken Institute Center for Strategic Philanthropy

The Milken Institute Center for Strategic Philanthropy advises individuals and foundations seeking to develop and implement transformational giving strategies. In addition, we provide resources and leadership to make the philanthropic landscape more effective. Our vision is for a more effective philanthropic ecosystem where dollars are spent strategically, donors realize the impact they seek, and people and the planet thrive.

SOURCE BD²