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Immune Advisors publica estudio revisado por pares que demuestra la eficacia de un suplemento probiótico y de enzimas digestivas en la protección contra los efectos secundarios de la quimioterapia para el cáncer
  • Brazil - Português
  • Deutschland - Deutsch

Compañía consultora centrada en la inmunoterapia presenta respaldo independiente al valor de Daily Body Restore ® para los pacientes con cáncer


News provided by

Immune Advisors, LLC

Aug 01, 2018, 08:07 ET

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SAN DIEGO, 1 de agosto de 2018 /PRNewswire/ -- Immune Advisors, LLC, una empresa con sede en California dedicada a la creación, el financiamiento y el desarrollo de compañías en el ámbito de la inmunoterapia y la medicina regenerativa, anunció hoy la publicación de un trabajo original titulado "Protection from chemotherapy- and antibiotic-mediated dysbiosis of the gut microbiota by a probiotic with digestive enzymes supplement" (Protección de la disbiosis mediada por quimioterapia y antibióticos de la flora intestinal por un probiótico con suplemento de enzimas digestivas). El trabajo se publicó en la revista Oncotarget, centrada en el cáncer y revisada por pares. El filántropo multimillonario John Paul DeJoria, cofundador de Paul Mitchell Hair Care Products, afirma: "Como inversor en Daily Body Restore®, estoy muy orgulloso de los resultados, y el estudio habla por sí mismo".

El artículo fue escrito por Thomas Ichim, Ph.D., de Immune Advisors, LLC, en colaboración con el Dr. Santosh Kesari, Ph.D., del Pacific Neuroscience Institute y el John Wayne Cancer Institute, y Kim Shafer, de Daily Body Restore®, LLC, desarrolladora del suplemento evaluado en el estudio.

Los resultados publicados demuestran que Daily Body Restore (DBR)®, un suplemento de venta en el mercado que combina nueve cepas de probióticos con diez enzimas digestivas, brinda beneficios para contrarrestar los efectos adversos de un agente quimioterapéutico, el 5-fluorouracilo (5-FU), y un antibiótico, la vancomicina, en el microbioma intestinal. Usando un modelo in vitro compuesto por biorreactores que simulaban las condiciones de los diversos compartimentos del tracto intestinal, se agregó DBR® en dosis in vivo y se evaluó la composición y la actividad de las bacterias intestinales. "Este estudio puso en práctica un modelo in vitro muy potente del microbioma intestinal para evaluar los efectos del probiótico con suplemento de enzimas digestivas", dice el Dr. Massimo Marzorati, fundador de ProDigest, la compañía belga que realizó la prueba in vitro de la disbiosis intestinal usada en la publicación. "El suplemento logró mejorar la cantidad y la actividad de las comunidades microbianas que tuvieron un impacto negativo por el agente quimioterapéutico y el antibiótico".

Puede accederse al artículo en https://doi.org/10.18632/oncotarget.25778.

Se sabe que los medicamentos quimioterapéuticos que usualmente se administran a pacientes con cáncer pueden tener un impacto negativo sobre el microbioma, que, a su vez, se cree que disminuye la eficacia de los tratamientos para el cáncer basados en inmunoterapia y provoca reacciones adversas tales como efectos secundarios gastrointestinales.1,2

Thomas E. Ichim, Ph.D., primer autor de la publicación, cofundador y socio gerente de Immune Advisors, LLC, comenta: "En los últimos años, en la comunidad médica y científica ha aumentado la comprensión de que la composición de las bacterias en el intestino está intrínsecamente implicada en la configuración del sistema inmune y la capacidad de respuesta de los fármacos. En mi opinión, los datos publicados hoy apoyan rotundamente la viabilidad de la administración de Daily Body Restore® a pacientes que están en tratamiento con quimioterapia".

Contacto: Thomas Ichim, Ph.D., socio gerente de Immune Advisors, LLC, [email protected], 858 353 0309

1 Routy y otros. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors (El microbioma intestinal influye en la eficacia de la inmunoterapia basada en PD-1 para los tumores epiteliales). Science. 5 de enero de 2018; 359(6371):91-97. http://science.sciencemag.org/content/359/6371/91.long
2 Alexander y otros. Gut microbiota modulation of chemotherapy efficacy and toxicity (Modulación de la microbiota intestinal de la eficacia y la toxicidad de la quimioterapia). Nat Rev Gastroenterol Hepatol. 14 de junio de 2017 (6):356-365. https://www.nature.com/articles/nrgastro.2017.20

FUENTE Immune Advisors, LLC

SOURCE Immune Advisors, LLC

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