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Ingenuity annonce du nouveau contenu microARN pour compléter la capacité de filtrage de la microARN unique en son genre dans IPA


News provided by

Ingenuity Systems

Sep 20, 2011, 06:00 ET

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REDWOOD CITY, Californie, September 20, 2011 /PRNewswire/ --

- Le nouveau contenu miRecords démontré expérimentalement améliore les fortes capacités de priorisation des cibles du dispositif microARN Target Filter d'IPA.

Ingenuity® Systems, fournisseur de premier plan de solutions informatiques et analytiques destinées aux chercheurs dans le domaine des sciences de la vie, a annoncé aujourd'hui l'ajout de nouvelles interactions cibles microARN-ARNm validées expérimentalement dans miRecords, ainsi que des milliers d'interactions miARN-ARNm supplémentaires, organisées manuellement et issues de publications avec comité de lecture supplémentaires. Ce contenu récemment ajouté vient compléter les cibles miARN prévues et démontrées expérimentalement, déjà disponibles dans IPA, et sera utilisé par le dispositif de filtrage cible de la microARN (microRNA Target Filter) dans IPA afin d'aider les chercheurs à prioriser les interactions cibles miARN, et ce, de manière rapide et fiable.

« IPA et son dispositif de filtrage cible de la microARN ont eu un impact considérable sur nos recherches », a déclaré Arupa Ganguly, Ph.D. professeur de génétique à l'hôpital universitaire de Pennsylvanie. « Nous avons comparé les signatures d'expressions génétiques des tissus rétiniens normaux appariés et le tissu tumoral dans le rétinoblastome, et par la suite nous avons utilisé IPA pour l'analyse biologique des données. En utilisant des microARN et ARNm provenant des mêmes tumeurs, nous avons appliqué le dispositif microARN Target Filter en combinaison avec le contenu disponible dans IPA. Cette approche nous a permis d'identifier rapidement des microARN clés qui jouent, d'après nous, un rôle dans la progression de la tumeur. »

Actuellement, il n'existe aucun outil logiciel sur le marché qui possède cette combinaison puissante d'outils et de contenu microARN tout en un. IPA permet aux chercheurs d'analyser tant les appariements microARN-ARNm prévus que ceux démontrés expérimentalement, de prioriser les cibles en fonction du contexte biologique pertinent, ainsi que de visualiser les interactions moléculaires de ces relations cibles et les incidences biologiques connexes. Cela permet de rationaliser le flux de travail qui prenait auparavant des jours ; les chercheurs peuvent désormais réduire des listes de plus de 13 000 cibles potentielles aux deux cibles les plus pertinentes biologiquement en quelques minutes seulement.

Pour en savoir plus au sujet du nouveau dispositif microARN Target Filter et du contenu disponible dans IPA, veuillez consulter notre page sur le produit ou regarder la vidéo microARN.

À propos de Ingenuity® Systems

Ingenuity Systems est un leader en matière de prestation de solutions informatiques et de services personnalisés destinés aux chercheurs dans le domaine des sciences de la vie, aux génématiciens, aux bioinformaticiens ainsi qu'aux fournisseurs de l'industrie des sciences de la vie. Pour en savoir plus, veuillez consulter : http://www.ingenuity.com

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