ISS National Lab Launches Orbital Edge Accelerator Program to Propel Startups Into the Growing Space Economy

CIRI, E2MC, and Stellar Ventures will invest in six startups for projects leveraging the ISS National Lab

KENNEDY SPACE CENTER, Fla., April 2, 2025 /PRNewswire/ -- The International Space Station (ISS) National Laboratory is taking a giant leap in fostering new space innovators with the launch of the Orbital Edge Accelerator program. This bold initiative is designed to integrate cutting-edge startups and investment partners into the rapidly expanding space economy. Through the accelerator, six pioneering startups will be selected to receive an investment of up to $500,000 each—which is being provided by global investors Cook Inlet Region, Inc. (CIRI), E2MC, and Stellar Ventures—along with mentorship and the opportunity to launch an ISS National Lab-sponsored investigation. By bridging the gap between early-stage companies and space-based innovation, the Orbital Edge Accelerator program aims to unlock discoveries that can benefit humanity and drive new commercial opportunities in low Earth orbit. 

Engaging the startup community is a strategic priority for the ISS National Lab. Having access to the unique space environment allows entrepreneurs to push the boundaries of science and technology, develop novel products, and build new businesses. Over the years, dozens of startups have been awarded flight opportunities through the ISS National Lab to advance R&D in diverse areas, from communications and remote sensing to advanced materials and biotechnology. The impact of conducting research through the ISS National Lab is notable, as startups awarded flight projects have cumulatively raised nearly $2.4 billion in funding postflight, demonstrating the value of space-based R&D in accelerating commercialization. With the launch of the Orbital Edge Accelerator, the ISS National Lab aims to build on this momentum and fuel the next wave of innovators that will shape the future space economy. 

To deliver the accelerator program, the ISS National Lab is working with TechConnect, which has more than 25 years of expertise connecting innovators with high-value commercialization opportunities. In the coming months, representatives from the ISS National Lab, CIRI, E2MC, Stellar Ventures, and TechConnect will meet with interested startups at conferences and networking sessions to highlight the accelerator and discuss how space-based R&D can lead to innovation not possible on Earth. Additionally, AWS will serve as corporate partner for the Orbital Edge Accelerator program, providing their extensive expertise and reach toward scouting and mentoring the inaugural cohort of startups.

TechConnect will host an informational webinar on April 22, 2025, at 2:00 p.m. EDT providing additional details on the scope of this opportunity and the advantages of utilizing the orbiting laboratory. To register, please visit the webinar registration page. TechConnect will also host two office hours for potential respondents to ask questions about the accelerator program. Learn more about these opportunities on the accelerator webpage.

Startups interested in the Orbital Edge Accelerator program will need to submit an application by 8:00 p.m. EDT on May 19, 2025. Once the application window closes, the ISS National Lab and investment partners will evaluate each submission and select up to 20 finalists to pitch in a virtual setting. From there, reviewers will invite six startups to join the Orbital Edge Accelerator cohort. Each startup will receive a $500,000 investment and the opportunity to submit an official proposal to utilize the ISS National Lab in a future spaceflight mission. 

The six selected startups will be joining attendees at the 14^th annual ISS Research and Development Conference in Seattle July 28-31, 2025. To learn more about the accelerator program, networking events, and application process, visit the Orbital Edge Accelerator webpage.

Download an image for this release: Orbital Edge Accelerator

About the International Space Station (ISS) National Laboratory:
The International Space Station (ISS) is a one-of-a-kind laboratory that enables research and technology development not possible on Earth. As a public service enterprise, the ISS National Laboratory^® allows researchers to leverage this multiuser facility to improve quality of life on Earth, mature space-based business models, advance science literacy in the future workforce, and expand a sustainable and scalable market in low Earth orbit. Through this orbiting national laboratory, research resources on the ISS are available to support non-NASA science, technology, and education initiatives from U.S. government agencies, academic institutions, and the private sector. The Center for the Advancement of Science in Space^® (CASIS^®) manages the ISS National Lab, under Cooperative Agreement with NASA, facilitating access to its permanent microgravity research environment, a powerful vantage point in low Earth orbit, and the extreme and varied conditions of space. To learn more about the ISS National Lab, visit our website.

As a 501(c)(3) nonprofit organization, CASIS accepts corporate and individual donations to help advance science in space for the benefit of humanity. For more information, visit our donations page.

About CIRI:
Cook Inlet Region, Inc. (CIRI) is a dynamic and forward-focused Alaska Native regional corporation, recognized as one of 12 land-based corporations established under the Alaska Native Claims Settlement Act (ANCSA). Since its incorporation on June 8, 1972, CIRI has expanded beyond its Southcentral Alaska roots—where its regional boundaries align with the traditional Dena'ina homeland—to become a global enterprise. Today, CIRI operates in 45 states and seven countries, driving growth, innovation, and opportunity for its more than 9,500 Shareholders who reside in Alaska and around the world. 

About E2MC:
E2MC (Earth-to-Mars Capital) is a pioneering venture capital firm dedicated to advancing the space economy by financing early-stage space-related startups globally. Our leadership team not only has a combined over 100 years' of space experience, but is also comprised of former entrepreneurs, and has extensive institutional investment experience. We leverage our specialized expertise and extensive global network to provide tangible support for our portfolio companies (over 20 so far). E2MC's mission, "From Earth into Space, for Earth," underscores our dedication to paving the way for humanity's expansion into space, and to harnessing space technology for global advancement and development. We are based in Arlington, VA.

About Stellar Ventures:
Stellar Ventures is a woman-led venture capital firm founded by aerospace industry leader Celeste Ford to back the next generation of space entrepreneurs. The firm invests in early-stage, mission-driven space technology companies and brings unmatched technical depth and industry connections to help founders build the world-changing businesses of tomorrow.

About TechConnect:
With 25+ years of experience connecting emerging technologies with unique funding and partnership opportunities, TechConnect boasts the most robust research and innovation network in the world, coupled with the nation's largest funder of innovation through its parent company, Advanced Technology International. It employs a broad scope of tools to deliver top technologies, including open innovation programs, conferences, and accelerators. Each year, TechConnect scouts, vets, and connects thousands of emerging technologies with corporate, investment, municipal, and national defense clients techconnect.org.

SOURCE International Space Station National Lab