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La soriasis podría estar relacionada con enfermedades cardiometabólicas según el International Psoriasis Council
  • USA - English
  • Latin America - español
  • USA - Deutsch
  • USA - Français


News provided by

International Psoriasis Council

Oct 06, 2014, 08:00 ET

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- El American Journal of Medicine publica el artículo del International Psoriasis Council en el que detalla las evidencia sobre cómo la soriasis podría estar relacionada con enfermedades cardiometabólicas

ST. LOUIS, 6 de octubre de 2014 /PRNewswire/ -- Las evidencias cada vez mayores de que los pacientes con soriasis tienen un riesgo superior de desarrollar enfermedades cardiovasculares y enfermedades metabólicas ("enfermedades cardiometabólicas") es el tema de un artículo que se publicará en el número de diciembre de 2014 del American Journal of Medicine.

El artículo, titulado "Accumulating Evidence for the Association and Shared Pathogenic Mechanisms between Psoriasis and Cardiometabolic Diseases", fue escrito por siete consejeros del International Psoriasis Council (IPC), una organización global centrada en la investigación de la soriasis, formación y cuidado a los pacientes. El artículo es un resumen de la reunión de noviembre de 2013 del IPC Think Tank, una reunión anual de expertos mundiales en soriasis para hablar acerca de los temas más destacados a los que se enfrenta el conocimiento y tratamiento de la enfermedad.

En la reunión, un panel mundial de especialistas en dermatología, inmunología y cardiovasculares habló acerca del estado de ka investigación acerca de la asociación potencial de la soriasis con varias comorbidades relacionadas con lo cardiometabólico.

Resumiendo estos debates, el artículo del American Journal of Medicine explora el potencial compartido de los mecanismos patogénicos, conectividad genética y relaciones inflamatorias entre la soriasis y varias enfermedades cardiometabólicas, como la enfermedad cardiaca, obesidad y diabetes.

"Es completamente único disponer de perspectivas expertas de una multitud de disciplinas en una sola vez. Estos tipos de interacciones aceleran nuestra comprensión de la asociación entre varias enfermedades cardiometabólicas y la soriasis", comentó el doctor Nehal N. Mehta, un experto en enfermedades cardiometabólicas que es coautor del artículo. "Basándose en las pruebas presentadas y destacadas en el simposio, la relación entre la soriasis y las enfermedades cardiometabólicas demuestran los fuertes lazos de mecanismo, y pese a ello las evidencias definitivas siguen siendo elusivas. Es necesario llevar a cabo más estudios para comprender mejor esta asociación".

Entre las conclusiones realizadas e identificadas en el manuscrito:

  • Existe una necesidad de dilucidar el enlace entre la soriasis y los mecanismos patofisiológicos cardiometabólicos con el objetivo de tratar mejor al paciente con soriasis.
  • Identificación de las rutas compartidas por medio de los estudios transcriptómicos (estudio del ARN) y de los estudios de asociación amplia del genoma (GWAS) que están avanzando el modelo de la soriasis hasta uno que sea análogo para otros estados sistémicos pro-inflamatorios, como la ateroesclerosis y el síndrome metabólico.
  • Las nuevas técnicas de imagen podrían ser una parte pivote para la identificación y cuantificación de la inflamación en la enfermedad cardiometabólicas y de la soriasis.
  • Los modelos de inflamación dentro de los sujetos humanos sanos han ilustrado un estado de tipo pro-inflamatorio caracterizado por los grandes aumentos de las citoquinas que son prominentes también en la soriasis, incluyendo TNF-a. Estos sujetos han demostrado cambios bioquímicos consistentes temporales con los encontrados dentro de las enfermedades cardiometabólicas, sugiriendo que la inflamación no precede a la enfermedad.
  • Los estudios prospectivos en pacientes que han comenzado con 30 años de edad para el control del desarrollo de las enfermedades metabólicas en la soriasis podrían ser la única forma definitiva de comprender mejor las relaciones temporales entre estas dos enfermedades.

"El Think Tank, que resulta del artículo, ejemplifica la misión del IPC acerca de reunir a los líderes dentro de la soriasis, avanzando así en nuestro conocimiento de esta enfermedad", explicó el profesor Christopher Griffiths, de la University of Manchester, Reino Unido, y director general del IPC.

Artículo disponible antes de impresión http://bit.ly/comorabstract

Visite http://www.psoriasiscouncil.org/news_comorbid.htm si desea leer el documento completo.

CONTACTO:

Steve O'Dell, consejero delegado
+1-814-323-7828

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