Mayo Clinic Board of Trustees elects Matthew R. Callstrom, M.D., Ph.D., as next president and CEO

ROCHESTER, Minn., Nov. 13, 2026 /PRNewswire/ -- The Mayo Clinic Board of Trustees announced today that it has elected Matthew R. Callstrom, M.D., Ph.D., to succeed Gianrico Farrugia, M.D., as president and CEO of Mayo Clinic. Dr. Farrugia will remain president and CEO through December 31, 2026, working closely with Dr. Callstrom to ensure a seamless transition.

"Dr. Callstrom is an accomplished physician-scientist and enterprise leader who brings nearly 25 years of experience at Mayo Clinic and a deep commitment to our values and mission," says Richard K. Davis, chair, Mayo Clinic Board of Trustees. "His leadership across patient care, research, strategy and innovation, combined with his ability to translate scientific discovery and emerging technology into meaningful advances for patients, prepares him exceptionally well to lead Mayo Clinic into its next chapter."

Dr. Callstrom joined Mayo Clinic in 2002 and has held leadership roles spanning clinical practice, research, strategy, AI and innovation. A member of Mayo Clinic's Board of Governors and Board of Trustees, he serves as medical director for Mayo Clinic Strategy and the AI Program and previously served as interim chief strategy officer and chair of the Department of Radiology at Mayo Clinic in Rochester. Across these roles, he has helped shape Mayo Clinic's organizational strategy and advance the responsible integration of AI into medicine, including efforts to accelerate the discovery of new cures, detect disease earlier and give clinicians new capabilities to care for patients with serious and complex conditions.

"I am deeply honored to have the opportunity to lead Mayo Clinic in this moment, serving alongside colleagues whose expertise, curiosity and commitment to our patients inspire me every day," says Dr. Callstrom. "Mayo Clinic has always been at its best when we bring the full power of our clinical expertise, science and innovation to the needs of the patient. Now, we have an opportunity to build on that foundation – accelerating the translation of discovery and emerging technologies into better care and extending Mayo Clinic's impact to more patients, wherever they are."

Dr. Callstrom has spent his career at the intersection of patient care, science and innovation. A physician-scientist and body interventional radiologist, he is internationally recognized for advancing image-guided cancer treatment, including the development of technologies that more precisely identify and treat cancer. He has led and collaborated on numerous clinical trials, and his work has resulted in more than 200 publications and patents. He has been recognized as a Mayo Clinic Distinguished Clinician and served as president of the Society of Interventional Oncology.

"Dr. Callstrom combines a deep understanding of Mayo Clinic with the ability to see what is coming next and bring people together to turn possibility into meaningful change for patients," Davis says. "He understands Mayo Clinic as a physician caring for patients, a scientist translating discovery into clinical care and a leader shaping our strategy for the future. That combination is invaluable as Mayo Clinic continues to advance its mission and transform healthcare."

A Minnesota native, Dr. Callstrom earned degrees in chemical engineering and chemistry from the University of Minnesota Twin Cities and completed a postdoctoral fellowship at Harvard University before earning his medical degree from Mayo Clinic Alix School of Medicine. He went on to complete his residency in diagnostic radiology and fellowship in cross-sectional imaging at Mayo Clinic in Rochester.

Dr. Callstrom will succeed Dr. Farrugia, who has served as president and CEO of Mayo Clinic since 2019. Under Dr. Farrugia's leadership, Mayo Clinic launched and advanced Bold. Forward., its strategy to transform healthcare by accelerating the discovery, translation and delivery of more cures for chronic and acute diseases; connecting people with data to create new knowledge and deliver scalable end-to-end solutions; and transforming healthcare by creating its first comprehensive, scalable, AI-enabled care transformation platform – Mayo Clinic Platform.

"Dr. Farrugia has led Mayo Clinic through a period of extraordinary transformation and progress while remaining steadfastly focused on our primary value: the needs of the patient come first," Davis says. "His leadership has strengthened Mayo Clinic and created tremendous momentum for the future. The Board is deeply grateful for Dr. Farrugia's continued service and contributions, including significant investments in Mayo Clinic's people, physical and digital infrastructure, education, research, AI and new care models, which leave Mayo Clinic so well positioned for its next chapter."

"It has been the privilege of my career to serve as president and CEO of Mayo Clinic and to work alongside extraordinary colleagues who share an unwavering commitment to patients," says Dr. Farrugia. "Dr. Callstrom knows Mayo Clinic deeply, understands where healthcare is headed and has the vision and experience to build on the progress we have made. I have great confidence in him and in Mayo Clinic's future."

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SOURCE Mayo Clinic