MilliporeSigma and genOway Form CRISPR/Cas9 Strategic Alliance to Develop Rodent Models

- genOway to acquire exclusive rights to MilliporeSigma's foundational genome-editing patents to produce, sell rodent models

- New technologies and solutions to be developed using CRISPR/Cas9 to accelerate delivery of better drugs to patients

BURLINGTON, Mass., Dec. 10, 2018 /PRNewswire/ -- MilliporeSigma, a leader in genome editing, today announced a strategic alliance in the CRISPR/Cas9 rodent model market with France-based biotechnology company genOway.

"We are committed to making our patented CRISPR technology broadly available to the global research and discovery community," said Udit Batra, CEO, MilliporeSigma. "Together with genOway, we will get the best research models out to the pharmaceutical and biotech industries as well as academic laboratories quickly, so we can help accelerate their research, shorten drug development timelines and treat previously untreatable diseases in faster and more targeted ways. We will continue to play an active role, responsibly and ethically, in ensuring that scientists have access to the latest CRISPR technologies."

Through an exclusive worldwide license of MilliporeSigma's foundational CRISPR integration patents, genOway will develop new models and solutions allowing non-profit and for-profit scientists to use CRISPR/Cas9 technology. Under the agreement, genOway will also develop a network of sublicensees in both the model creation and distribution businesses and preclinical services for all potential applications worldwide, with a strong focus in the United States, Asia and Europe. Financial details were not disclosed.

Both MiliporeSigma and genOway have identified research fields where they can combine their respective technologies and expertise to develop and validate new CRISPR/Cas9-related products and solutions. MilliporeSigma's patented CRISPR integration technology is a strong entry point through which innovation can be developed and launched.  

At MilliporeSigma, excellence and expertise in animal care, use and welfare are of the highest priority. In line with its mission to develop innovative medicines and chemicals based on scientific excellence and the established ethical standards, MilliporeSigma is committed to conducting animal research activities only if no other method or testing is available for obtaining the result or product sought, not entailing the use of a live animal.

"The CRISPR/Cas9 IP landscape has been complex and uncertain over the last years," said Alexandre Fraichard, CEO of genOway. "The situation has changed and the MilliporeSigma IP portfolio is clearly central to CRISPR/Cas9-based eukaryotic genome-editing applications. This alliance, combining research and business, will enable us to provide the scientific community with more physiologically relevant models and the necessary intellectual property rights which will ultimately speed delivering better drugs to patients."

CRISPR technology is a core competency for MilliporeSigma, which has 14 years' experience with genome editing, spanning from discovery to manufacturing. MilliporeSigma recognizes that genome editing has resulted in major advancements in biological research and medicine.  At the same time, the growing potential of genome-editing technologies has opened scientific, legal and societal concerns. MilliporeSigma supports research with genome editing under careful consideration of ethical and legal standards. MilliporeSigma's parent company, Merck KGaA, Darmstadt, Germany, has established an independent, external Bioethics Advisory Panel to provide guidance for research in which its businesses are involved, including research on or using genome editing, and has developed, defined and transparently published a clear operational position taking into account scientific and societal issues to inform promising therapeutic approaches for use in research and applications.

About genOway
genOway (ALTERNEXT-NYSE: ALGEN) is a biotechnology company developing genetically modified and high value-added research models for the bio-pharmaceutical, chemical, agrochemical and food industries as well as for academic research. With highly qualified scientific personnel, the company has a workforce of 95 people and operates in 28 countries in Europe, Asia and North America, supplying more than 275 customers. It is a market leader in terms of both size and customer portfolios. The company's development is founded upon both a broad and exclusive technology platform as well as strong intellectual property rights combining patents and licensing agreements. Taking advantage of the global trend towards outsourcing the production of genetically modified research models, genOway has signed contracts with leaders of the pharmaceutical industry (Janssen R&D, GSK, Pfizer, etc.), and with prestigious academic research centers (King's College and the University of Manchester, in England; Harvard, Caltech and the National Institutes of Health, in the United States; the Institut Pasteur, in France; NGFN and the Max Planck Institutes, in Germany, etc.). 
For more information, visit our web site www.genoway.com 

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About the Life Science Business of Merck KGaA, Darmstadt, Germany
The Life Science business of Merck KGaA, Darmstadt, Germany, which operates as MilliporeSigma in the U.S. and Canada, has 20,000 employees and 60 manufacturing sites worldwide, with a portfolio of more than 300,000 products enabling scientific discovery. Udit Batra is the global chief executive officer of MilliporeSigma.

Merck KGaA, Darmstadt, Germany completed its $17 billion acquisition of Sigma-Aldrich in November 2015, creating a leader in the $125 billion global life science industry.

Merck KGaA, Darmstadt, Germany, the vibrant science and technology company, operates across healthcare, life science and performance materials. Around 51,000 employees work to make a positive difference to millions of people's lives every day by creating more joyful and sustainable ways to live. From advancing gene-editing technologies and discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2017, Merck KGaA, Darmstadt, Germany generated sales of €15.3 billion in 66 countries.

The company holds the global rights to the name and trademark "Merck" internationally. The only exceptions are the United States and Canada, where the business sectors of Merck KGaA, Darmstadt, Germany operate as EMD Serono in healthcare, MilliporeSigma in life science, and EMD Performance Materials. Since its founding 1668, scientific exploration and responsible entrepreneurship have been key to the company's technological and scientific advances. To this day, the founding family remains the majority owner of the publicly listed company. For more information about Merck, KGaA, Darmstadt, Germany, visit www.emdgroup.com.

SOURCE MilliporeSigma