Nanotechnology for Medical Diagnostics

NEW YORK, March 19, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Nanotechnology for Medical Diagnostics http://www.reportlinker.com/p0799334/Nanotechnology-for-Medical-Diagnostics.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Nanotechnology

Following on from our "Nanotechnology for Drug Delivery" series of reports we are turning the focus onto medical diagnostics with our latest report: "Nanotechnology for Medical Diagnostics"

Nanotech enabled medical diagnostics promise to improve just about everything that can be improved from a diagnostics point of view: earlier detection of disease, higher sensitivity, higher accuracy, higher throughput capability, more results per assay; time saving and cost-effectiveness.

As with our "Nanotechnology for Drug Delivery" series of reports, this report provides a market numbers for the nanotech enabled medical diagnostic market between 2000-2010 and a market forecast for the period 2011-2021.

Report Scope

Two sets of data are presented in this report:

The TAM growth for NMBD between 2000-2010;TAM forecast for NMBD between 2011- 2021.

Both sets of data are segmented into;

TAM (US$ millions, % share, and CAGR) for:

America

Asia (key economies)

Europe (key economies)

RoW (key economies)

Technology type (US$ millions, % share and CAGR) for;

Main Technological Approaches:

Quantum dots (QDs);Gold nanoparticles;Cantilevers;Exosomes;Nanobiosensors;

Main Technological Applications:

Nanotechnology-based medical and biomedical imaging for diagnostics;Nanotechnology-based medical devices for diagnostics;

Nanotechnology in Early Disease Detection.

Geographical Scope

The studied regions are:

North America:USA;European Union (27):Germany;France;UK;Other Countries of EU;Russian FederationAsia:India;Japan;P. R. China;South Korea (R. of Korea);Taiwan;RoWQuantifying the Total Addressable Market (TAM)Current

The TAM for nanotech enabled diagnostics is estimated to be 2.439 US$ Billion (end of 2011).

Nanotechnology applied to medical imaging and gold nanoparticles for diagnosis were the application and technology respectively, with the highest growth during the last decade, currently (2011 figures) at:

Medical Imaging: 1.7 Billion US$

Gold Nanoparticles: 959 Million US$

While the US, China and Germany were the countries with the highest growth currently (2011 figures) at:

North America: 675 Million US$

China: 330 Million US$

Germany: 117 Million US$

Forecast

We forecast the TAM for nanotech enabled diagnostics to reach $53.6B in 2021. In comparison our report "Nanotechnology for Drug Delivery" forecasts a TAM of $136B in 2021 for nanotech enabled drug delivery.

In 2021, Asia (China, Japan, South Korea, Taiwan, India combined) tops the list with the highest TAM, China and India are neck and neck for CAGR.

Of all the technologies studied for this report, exosomes for diagnosis show the highest CAGR between 2011-2021 while medical imaging remains the highest growth application of the nanotech enabled diagnostics market in 2021.

Table of ContentsChapter One 7Chapter Two 7Chapter Three 7Chapter Four 8Appendix 17ExecutiveSummary20CHAPTER 127INTRODUCTION AND METHODOLOGY 27Report Scope 27Scope of Data Analysis 27Thematic Scope 28Geographical Scope 31Methodology 31Procurement 32Calculation of CAGR 32The Nanoscale 33Two biological examples that illustrate nanoscale: 34CHAPTER 236INTRODUCTION TO NANOTECHNOLOGY & MEDICINE - OVERVIEW OF NANOTECHNOLOGY 36Why is Nanotechnology A Critical Application for Medicine and Biomedicine? 36Why Nanotechnology Is Needed for Medicine and Biomedicine? 38WHAT ARE THE KEY DRIVERS FOR ADOPTION OF NANOTECHNOLOGY IN MEDICINE ANDBIOMEDICINE? 41The Aim Of Targeting For Detection, Quantification And Characterization Purposes –Molecular Recognition in Nanotechnology in Medical And Biomedical Diagnostics 41Reasons Why The Market of Nanotechnology in Medical And Biomedical DiagnosticsExpanded so Rapidly During The 2000-2010 Decade 45Market Drivers For Nanotechnology-Based Medical And Biomedical Diagnostics 46Reasons Why The Market of Nanotechnology in Medical And Biomedical Diagnostics WillRapidly Expand 46Drivers For Synergies Between Nanotechnology in Medical And Biomedical DiagnosticsAnd Nanotechnology in Drug Delivery 47Increasing Proportion of The Ageing Population 47Demand For More Affordable Health Care 49Public Health – Ending disease 49Demand For More Innovation 49Social Responsibility 49THE MOST IMPORTANT FIELDS IN THE ADOPTION OF NANOTECHNOLOGY IN MEDICINE ANDBIOMEDICINE 50Nanotechnology in Drug Delivery 51Nanotechnology in Medical and Biomedical Diagnostics 52Nanotechnology in Regenerative Medicine and Tissue Engineering 52Other Applications For Nanomaterials In The Medical And Pharmaceutical Sector 52HOW NANOTECHNOLOGY IS ALREADY HAVING AN IMPACT IN MEDICAL AND BIOMEDICALDIAGNOSTICS 53Case Study 1 – Diagnosis of head-and-neck cancer from exhaled breath 53Case Study 2 – UTSA researchers embracing nanotechnology to accelerate diagnostics 54Case Study 3 – Biocompatible graphene transistor array reads and records action potentialsfrom electrogenic cells 54CHAPTER 359KEY BARRIERS TO THE ADOPTION OF NANOTECHNOLOGY IN MEDICINE AND BIOMEDICINE 59Nanotoxicity Nanopollution and Nanosafety 59Ethical Considerations of Nanotherapies 61Delayed Nanoregulation 62CURRENT & FUTURE CHALLENGES IN THE ADOPTION OF NANOTECHNOLOGY IN MEDICINEAND BIOMEDICINE 65Current & Future Challenges of Nanosafety And Risk Management 66Current & Future Challenges of Nanoregulation 68Current & Future Challenges of Nanomedicine Industry 70Current & Future Challenges of Sustained Innovation 71Current & Future Challenges of Cooperation 71TAM ANALYSIS, WITHOUT SEGMENTATION (2000-2010) 72TAM FORECAST , WITHOUT SEGMENTATION (2011-2021) 75CHAPTER 480OVERVIEW OF THE KEY NANOTECHNOLOGIES USED IN MEDICAL AND BIOMEDICALDIAGNOSTICS SORTED BY APPLICATIONS 80Nanotechnology in Medical and Biomedical Diagnostics: Diagnostics Nanotechnologies 81Quantum Dots 83Preparing Quantum Dots 84Operation of Quantum Dots 84Detection of Quantum Dots 85Features And Benefits of Quantum Dots 85Disadvantages of Quantum Dots 87Application of Quantum Dots to Medical And Biomedical Nanotechnology-BasedDiagnostics Assays 89Prostate-specific antigen assay 90Acetylcholine assay 90Targeting of membrane protein P-glycoprotein (Pgp) in HeLa cells that had beentransiently transfected by a plasmid encoding for Pgp 91Cellular organelles assay 91Cancer detection assay 91Imaging assays 92Gold Nanoparticles 92Application of Gold nanoparticles to Medical And Biomedical Diagnostics Assays 93PSA assay 93Alzheimer's disease BCA 94BCA as a possible alternative for PCR 95Cantilevers 95Application of Cantilevers to Medical And Biomedical Diagnostics Assays 96Exosomes 98Microvesicles Overview 98Microvesicles as Mediators of Intercellular Communication 98Types of Released Microvesicles 99Intracellular Origin of Exosomes 99Exosomes as Nanotechnology in medical and biomedical diagnostics Biomarkers 100Nanobiosensors 100Medical and Biomedical Imaging 102Fluorescent Nanoparticles 102In vivo nanoparticle-based near-infrared fluorescence (NIRF) imaging techniques 103Nanobioimaging 104Nanotechnology-Based Medical Devices For Diagnostic 104Nanopatterned Medical Devices for Diagnostic 107Nanoporous Silica Nanochips 107Nanowire Biosensors 109Micro- And Nanocantilever Arrays 111Molecularly Gated Single Electron Transistors 112The Most Relevant Technologies in The Key Area of Nanotechnology in Medical AndBiomedical Diagnostics 114STAGE OF DEVELOPMENT OF KEY NANOTECHNOLOGIES USED IN MEDICAL AND BIOMEDICALDIAGNOSTICS 114Genomics and Proteomics in Nanotechnology in Medical and Biomedical Diagnosis in aContext of Personalized Medicine 114The Potential of The Adoption of Nanotechnology to Medical And BiomedicalDiagnostics 115TAM ANALYSIS, WITH SEGMENTATION (2000-2010) 118TAM by Country 118TAM by Key Technology 138TECHNOLOGY ADOPTION ROADMAP 161Projected Product Pipeline For Nanotechnology-Based Medical and BiomedicalDiagnostics Market 161Projected Product Pipeline For Nanotechnology-Based Medical Devices For Medical AndBiomedical Diagnostics 162Projected Product Pipeline For Nanotechnology-Based Medical Devices For Theranostics162Projected Product Pipeline For Nanotechnology-Based Medical Imaging For Medical AndBiomedical Diagnostics 163TAM FORECAST, WITH SEGMENTATION (2011- 2021) 164TAM Forecast by Country 164TAM forecast by Key Technology 189SWOT ANALYSIS (2011-2021 PERIOD) 213APPENDIX216Publishing activity by organization (2000-2010) 216

TABLE OF EXHIBITS

CHAPTERONEExhibit 1.1Formula for the calculation of the Compound Annual Growth Rate (CAGR) [2].Exhibit 1.2Formula for the verification of the calculated values of CAGR (2011-2021) [2].Exhibit 1.3Metres in a nanometre (top), nanometres in a metre (bottom)CHAPTERTWOExhibit 2.1Illustration of the fact that the periodic table of elements, as we know it (at meter scale)governed by classic Newtonian laws of physics. However, when perceived at nanoscale,those elements are governed by the laws of quantum physics.Exhibit 2.2Proportion of the population aged over 65 and over 80 [8].CHAPTERTHREEExhibit 3.1Key barriers to the adoption of nanotechnology in medicine and biomedicine (Source:Cientifica, Ltd.).Exhibit 3.2Specified expected barriers in the development of particular types of nanoparticles(Courtesy of CienNanoroadmap Synthesis Report), [6].Exhibit 3.3Table representing the Total Addressable Market, TAM (2000-2010), for nanotechnologyin medical and biomedical diagnostics, without segmentation, source: Cientifica (all figuresUS$ Million Dollars).Exhibit 3.4Line chart representing Total Addressable Market, TAM (2000-2010), for nanotechnologyin medical and biomedical diagnostics, without segmentation, source: Cientifica (all figuresUS$ Million Dollars).Exhibit 3.5Bar chart representing Total Addressable Market, TAM (2000-2010), for nanotechnologyin medical and biomedical diagnostics, without segmentation, source: Cientifica (all figuresUS$ Million Dollars).Exhibit 3.6Table representing the Total Addressable Market, TAM forecast to 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, withoutsegmentation, source: Cientifica (all figures US$ Million Dollars).Exhibit 3.7Line chart representing the Total Addressable Market, TAM forecast to 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, withoutsegmentation, source: Cientifica (all figures US$ Million Dollars).Exhibit 3.8Bar chart representing the Total Addressable Market, TAM forecast to 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, withoutsegmentation, source: Cientifica (all figures US$ Million Dollars).CHAPTERFOURExhibit 4.1Summarized comparison of characteristics of quantum dots (QDs), cantilevers and goldnanoparticles in the scope of the adoption of nanotechnology to clinical diagnosis [3].Exhibit 4.2Schematic diagram representing the general structure of a Quantum dot (in this case, atypical CdSe/ZnS QD). The coating extremities can change according to requirementsregarding application and biocompatibility (e.g. mercaptoacetic acid or streptavidin) [3].Exhibit 4.3A schematic diagram of a multiplex QD-based assay. Multiple antigens (Ag) can be labelledthrough the use of primary antibodies (Ab) conjugated to QDs with different sizes. Oneantibody may be biotinylated and detected with a streptavidin-coated QD. On excitation,QDs will have different emission maxima based on their sizes [3].Exhibit 4.4A summary of toxicity breakthroughs standing on selected quantum dots studies [3].Exhibit 4.5Selected examples of quantum dots-based assays. The presented quantum dots havedifferent recognition moieties [3].Exhibit 4.6Examples of the adoption of nanotechnology to medical and biomedical diagnosis and asummary of the characteristics of those technologies [3].Exhibit 4.7Schematic representation of production and release of exosomes. The exocyticmultivesicular bodies may fuse with membrane and release exosomes [4].Exhibit 4.8Table representing the Total Addressable Market, TAM (2000-2010), for nanotechnologyin medical and biomedical diagnostics, all countries studied, source: Cientifica (all figuresUS$ Million Dollars).Exhibit 4.93-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, by world regions and countries,source: Cientifica (all figures in percentage).Exhibit 4.10Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, by world regions and countries,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.11Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, by world regions and countries,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.123-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in medical and biomedical diagnostics, by world regions andcountries, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.133-D stacked area chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, by world regions and countries,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.143-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, all world regions and countriesstudied, source: Cientifica (all figures in percentage).Exhibit 4.15Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, all world regions and countriesstudied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.163-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, European Union countries studied,source: Cientifica (all figures in percentage).Exhibit 4.17Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, European Union countries studied,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.18Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, European Union countries studied,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.193-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in medical and biomedical diagnostics, European Unioncountries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.203-D stacked area chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, European Union countries studied,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.213-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, Asian countries studied, source:Cientifica (all figures in percentage).Exhibit 4.22Horizontal bar graph representing the Total Addressable Market, TAM In 2010, fornanotechnology in medical and biomedical diagnostics, Asian countries studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.23Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, Asian countries studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.243-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010), for nanotechnology in medical and biomedical diagnostics, Asian countries studied,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.253-D stacked area chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, Asian countries studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.26Table representing the Total Addressable Market, TAM (2000-2010), for nanotechnologyin medical and biomedical diagnostics, all most relevant key technologies, source: Cientifica(all figures US$ Million Dollars).Exhibit 4.273-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, all key technologies studied, source:Cientifica (all figures in percentage).Exhibit 4.28Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, all key technologies studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.29Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, all key technologies studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.303-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in medical and biomedical diagnostics, all key technologiesstudied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.313-D stacked area chart representing the Total Addressable Market, TAM (2000-2010) , fornanotechnology in medical and biomedical diagnostics, all key technologies studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.323-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, technological approaches as awhole, source: Cientifica (all figures in percentage).Exhibit 4.33Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, technological approaches as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.34Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, technological approaches as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.353-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in medical and biomedical diagnostics, technologicalapproaches as a whole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.363-D stacked area chart representing the Total Addressable Market, TAM (2000-2010) , fornanotechnology in medical and biomedical diagnostics, technological approaches as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.373-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, technological applications as awhole, source: Cientifica (all figures in percentage).Exhibit 4.38Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, technological applications as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.39Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, technological applications as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.403-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in medical and biomedical diagnostics, technologicalapplications as a whole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.413-D stacked area chart representing the Total Addressable Market, TAM (2000-2010) , fornanotechnology in medical and biomedical diagnostics, technological applications as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.423-D pie chart representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, impact of early disease detection,source: Cientifica (all figures in percentage).Exhibit 4.43Horizontal bar graph representing the Total Addressable Market, TAM in 2010, fornanotechnology in medical and biomedical diagnostics, impact of early disease detection,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.44Line chart representing the Total Addressable Market, TAM (2000-2010), fornanotechnology in medical and biomedical diagnostics, impact of early disease detection,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.453-D stacked vertical bar graph representing the Total Addressable Market, TAM (2000-2010) , for nanotechnology in medical and biomedical diagnostics, impact of early diseasedetection, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.463-D stacked area chart representing the Total Addressable Market, TAM (2000-2010) , fornanotechnology in medical and biomedical diagnostics, impact of early disease detection,source: Cientifica (all figures US$ Million Dollars).Exhibit 4.47Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, by world regions/ countries, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.483-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, by world regions, source: Cientifica(all figures in percentage).Exhibit 4.49Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, by world regions, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.50Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics, by worldregions, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.513-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, by world regions, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.523-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, byworld regions, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.533-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, by all world regions / countriesstudied, source: Cientifica (all figures in percentage).Exhibit 4.54Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, by all world regions / countriesstudied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.55Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics, by all worldregions / countries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.563-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, by all world regions / countries studied, source: Cientifica (all figures US$Million Dollars).Exhibit 4.573-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, byall world regions / countries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.583-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, European Union countries studied,source: Cientifica (all figures in percentage).Exhibit 4.59Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, European Union countriesstudied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.60Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics, EuropeanUnion countries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.613-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, European Union countries studied, source: Cientifica (all figures US$ MillionDollars).Exhibit 4.623-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics,European Union countries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.633-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, Asian countries studied, source:Cientifica (all figures in percentage).Exhibit 4.64Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, Asian countries studied, source:Cientifica (all figures US$ Million Dollars).Exhibit 4.65Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics, Asiancountries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.663-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, Asian countries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.673-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics,Asian countries studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.68Table representing the Total Addressable Market, TAM forecast by 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, all most relevantkey technologies, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.693-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, all key technologies studied, source:Cientifica (all figures in percentage).Exhibit 4.70Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, all key technologies studied,source: Cientifica (all figures in percentage).Exhibit 4.71Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics, all keytechnologies studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.723-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, all key technologies studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.733-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics, allkey technologies studied, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.743-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, technological approaches as awhole, source: Cientifica (all figures in percentage).Exhibit 4.75Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, technological approaches as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.76Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics,technological approaches as a whole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.773-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, technological approaches as a whole, source: Cientifica (all figures US$ MillionDollars).Exhibit 4.783-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics,technological approaches as a whole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.793-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, technological applications as awhole, source: Cientifica (all figures in percentage).Exhibit 4.80Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, technological applications as awhole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.81Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics,technological applications as a whole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.823-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, technological applications as a whole, source: Cientifica (all figures US$ MillionDollars).Exhibit 4.833-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics,technological applications as a whole, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.843-D pie chart representing the Total Addressable Market, TAM forecast in 2021, fornanotechnology in medical and biomedical diagnostics, impact of early disease detection,source: Cientifica (all figures in percentage).Exhibit 4.85Horizontal bar graph representing the Total Addressable Market, TAM forecast in 2021,for nanotechnology in medical and biomedical diagnostics, impact of early diseasedetection, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.86Line chart representing the Total Addressable Market, TAM forecast by 2021 (for the2011-2021 period), for nanotechnology in medical and biomedical diagnostics, impact ofearly disease detection, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.873-D stacked vertical bar graph representing the Total Addressable Market, TAM forecastby 2021 (for the 2011-2021 period), for nanotechnology in medical and biomedicaldiagnostics, impact of early disease detection, source: Cientifica (all figures US$ MillionDollars).Exhibit 4.883-D stacked area chart representing the Total Addressable Market, TAM forecast by 2021(for the 2011-2021 period), for nanotechnology in medical and biomedical diagnostics,impact of early disease detection, source: Cientifica (all figures US$ Million Dollars).Exhibit 4.89SWOT analysis to evaluate the strengths, weaknesses, opportunities and threats involved innanotechnology in medical and biomedical diagnostics, in the scope of the technologyadoption roadmap (during the 2011-2021 period).APPENDIXExhibit A.1Table of the top 20 organizations showing the highest publishing activity in PubMedperiodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. WorldRegion: North America; country: USA.Organizations are ordered first by descending order of total articles published and thenordered alphabetically (increasing order), if applicable.Exhibit A.2Table of the top 20 organizations showing the highest publishing activity in PubMedperiodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. WorldRegion: European Union; country: Germany.Organizations are ordered first by descending order of total articles published and thenordered alphabetically (increasing order), if applicable.Exhibit A.3Table of the top 20 organizations showing the highest publishing activity in PubMedperiodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. WorldRegion: European Union; country: France.Organizations are ordered first by descending order of total articles published and thenordered alphabetically (increasing order), if applicable.Exhibit A.4Table of the top 20 organizations showing the highest publishing activity in PubMedperiodicals (2000-2010), based on PubMed, for Nanotechnology in Drug Delivery. WorldRegion: European Union; country: UK.Exhibit A.5Table of the organizations with publishing activity in PubMed periodicals (2000-2010),based on PubMed, for Nanotechnology in Drug Delivery. Country: Russian Federat

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