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Neurelis to Host Virtual Pipeline Update to Discuss Advancements Addressing Unmet Needs in Neuroscience on March 7, 2024


News provided by

Neurelis, Inc.

Feb 26, 2024, 09:00 ET

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  • Investor call to feature presentations from Leslie Lucien Citrome, MD, MPH, Issam Awad, MD, FACS and Connie Lee, PsyD

SAN DIEGO, Feb. 26, 2024 /PRNewswire/ -- Neurelis, Inc., today announced it will host an investor call to highlight updates on two of its neuroscience product development candidates, NRL-1004 for acute agitation episodes and NRL-1049 for cerebral cavernous malformations (CCMs). The investor call will be held virtually on Thursday, March 7, 2024 at 10:30 AM ET. To register, click here.

Agenda Topics

NRL-1004 for Acute Agitation Episodes – 10:30 am - 11:15 am ET

  • NRL-1004, an investigational nasal spray formulation of olanzapine and Neurelis proprietary Intravail® technology, for the treatment of acute agitation episodes, featuring Leslie Lucien Citrome, MD, MPH (New York Medical College, SUNY Upstate Medical University, Icahn School of Medicine at Mount Sinai).

NRL-1049 for Cerebral Cavernous Malformations – 11:15 am - 12:00 pm ET

  • NRL-1049, an investigational, Phase 1, new chemical entity, Rho kinase (ROCK) inhibitor, for the treatment of cerebral cavernous malformations (CCMs), featuring Issam Awad, MD, MSc, FACS, MA (University of Chicago Medicine) and Connie Lee, PsyD (Alliance to Cure Cavernous Malformation)

Presentations will include overviews of the disease state, unmet need, and current treatment landscape for patients, as well as a discussion of the potential differentiating features of Neurelis' product candidates. A live question and answer session will follow the formal presentations of both segments.

About Leslie Lucien Citrome, MD, MPH 

Leslie Lucien Citrome, MD, MPH is Clinical Professor of Psychiatry and Behavioral Sciences at New York Medical College in Valhalla, New York, Clinical Professor of Psychiatry at SUNY Upstate Medical University, and Adjunct Clinical Professor of Psychiatry, Icahn School of Medicine at Mount Sinai in New York City, New York. He is a Distinguished Life Fellow of the American Psychiatric Association and a Fellow of the American Society of Clinical Psychopharmacology where he currently serves as Immediate Past-President. In addition to his academic positions, he has a private practice in psychiatry in Pomona, New York and is a volunteer consultant to the Assertive Community Treatment team/Mental Health Association of Rockland County. Dr. Citrome obtained his MD degree from the McGill University Faculty of Medicine in 1983 and his MPH degree from the Columbia School of Public Health in 1996. His immediate prior position was as the founding Director of the Clinical Research and Evaluation Facility at the Nathan S. Kline Institute for Psychiatric Research in Orangeburg, New York, where he worked from 1994 through 2010 and achieved the rank of Professor of Psychiatry at the New York University School of Medicine. Dr. Citrome is currently a consultant in clinical trial design and interpretation. He is a frequent lecturer on the quantitative assessment of clinical trial results, including the metrics of number needed to treat and number needed to harm, and has lectured throughout the Americas, Europe, Asia, and Australasia. His main interests include schizophrenia, bipolar disorder, and major depressive disorder. He is author or coauthor of over 600 research reports, reviews, and chapters in the scientific literature. He is a member of the Board of Directors of the World Association of Medical Editors. Dr. Citrome is editor-in-chief of Current Medical Research and Opinion (CMRO) published by Taylor & Francis, editor emeritus, International Journal of Clinical Practice where he was editor-in-chief 2013-2019; psychiatry topic editor for Clinical Therapeutics; editor for the American Society of Clinical Psychopharmacology Corner in the Journal of Clinical Psychiatry; section editor for psychopharmacology for Current Psychiatry; and also serves as an editorial board member for several other medical journals.

About Issam Awad, MD, FACS

Issam Awad, MD, MSc, FACS, MA is the John Harper Seeley Professor of Neurological Sciences at the University of Chicago. He leads the Neurovascular Surgery Program, co-leads the Stroke and Neurovascular Care team at UChicago Medicine, and Directs of the Safadi Program of Excellence in Clinical and Translational Neuroscience and the first accredited Center of Excellence for Cerebral Cavernous Malformations (CCM) in the U.S. His research focuses on vascular biology, genetics and comprehensive outcome analysis in neurovascular disease and stroke, and his active projects include National Institutes of Health and department of Defense funded investigations of molecular mechanisms involved in the formation and progression of cerebrovascular malformations. Additionally, he leads several clinical trials on minimally invasive techniques for surgical treatment of hemorrhagic stroke and novel drug therapies for Cavernous Angiomas with Symptomatic Hemorrhage (CASH). Dr. Awad's scientific innovations include the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of cerebral vascular malformations and numerous technical advances in neurovascular and epilepsy surgery. He has authored leading textbooks and published more than 350 scholarly papers related to clinical innovations, surgical outcomes and research. He has also served as president of the Congress of Neurological Surgeons, chairman of the Cerebrovascular Section of the American Association of Neurological Surgeons and Congress of Neurological Surgeons, and on the executive committee of the American Stroke Association and the board of governors of the American College of Surgeons. He served on the U.S. National Council for Neurological Disorders and Stroke and is the founding chairman of the Scientific Advisory Board of the Alliance to Cure Cavernous Malformation.

About Connie Lee, PsyD

Connie Lee, PsyD is the founding President of the Alliance to Cure Cavernous Malformation. Connie is a licensed clinical psychologist and the mother of a daughter with multiple cavernous malformations. Connie's personal story with cavernous malformation began in January 2000. At that time, Connie's 4-month-old daughter Julia received brain surgery for a major hemorrhage and hydrocephalus caused by a cavernous malformation. Dr. Lee founded Angioma Alliance, the original name of the Alliance to Cure, in 2002. She has guided the organization from its beginnings as a support group to its current role as the driving force for research, legislation, and patient care.

About Neurelis

Neurelis, Inc., is a neuroscience company focused on the development and commercialization of therapeutics for the treatment of epilepsy and orphan neurologic disorders characterized by high unmet medical needs. In 2020, the FDA approved Neurelis' VALTOCO® (diazepam nasal spray) as an acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from an individual's usual seizure pattern in adult and pediatric patients 6 years of age and older. VALTOCO is a proprietary formulation of diazepam incorporating the science of INTRAVAIL®. For more information on VALTOCO, please visit www.valtoco.com. For more information on Neurelis. please visit www.neurelis.com. For the latest scientific information on VALTOCO, please visit http://www.neurelismedicalaffairs.com.

Contacts:

Neurelis:
Brittany Bradrick, Chief Operating Officer and Chief Financial Officer, +1 858 251 2100

Media:
Glenn Silver, FINN Partners, +1 646 871 8485

SOURCE Neurelis, Inc.

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NEURELIS TO PRESENT STUDY OF NRL-1049, A RHO KINASE (ROCK) INHIBITOR WITH POTENTIAL TO TREAT SYMPTOMATIC CEREBRAL CAVERNOUS MALFORMATIONS (CCM), AT ANNUAL CCM MEETING

NEURELIS TO PRESENT STUDY OF NRL-1049, A RHO KINASE (ROCK) INHIBITOR WITH POTENTIAL TO TREAT SYMPTOMATIC CEREBRAL CAVERNOUS MALFORMATIONS (CCM), AT ANNUAL CCM MEETING

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