LONDON, December 15, 2016 /PRNewswire/ --
Shilpa Gupta, Neeraj Agarwal, Oncology & Hematology Review, 2016;12(2):82-8, https://doi.org/10.17925/OHR.2016.12.02.82
Published recently in Oncology & Hematology Review, the peer-reviewed journal from touchONCOLOGY, Shilpa Gupta discusses high-dose interleukin-2 (HD IL-2), which has been in clinical use in the treatment of metastatic renal cell carcinoma (mRCC) and metastatic melanoma (mM) for over 20 years, and has produced substantial, durable responses in selected patients, resulting in cures in some patients with no ongoing therapy or chronic toxicity. However, use of the drug has remained limited owing to its significant acute toxicities, and the fact that only a minority of selected patients derive a response to treatment. Recent registry data support the use of HD IL-2 as first-line therapy in mRCC and mM, producing major responses for some and thus reducing the requirement for long-term therapy. In addition, an enhanced understanding of the role of IL-2 has led to the development of new therapeutic approaches to maximize the anti-tumor response of IL-2. These strategies include combined treatment with vaccines, antibody treatments to block inhibitory pathways, or adoptive cell transfer of T cells. These data and new approaches have led to continued use of HD IL-2 and may increase the number of patients who derive benefit from this treatment.
The full peer-reviewed, open-access article is available here:
Disclosure: Shilpa Gupta has participated in Advisory Boards and speakers' bureau for Genentech. Neeraj Agarwal has participated in Advisory Board for Pfizer, Exelixis, Cerulean, Argo and received research funding from Pfizer. This study involves a review of the literature and did not involve any studies with human or animal subjects performed by any of the authors.
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