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OGT simplifica la detección de importantes variantes de genes de cáncer
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News provided by

Oxford Gene Technology (OGT)

Sep 27, 2016, 04:00 ET

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Oxford Gene Technology (PRNewsFoto/Oxford Gene Technology)
Oxford Gene Technology (PRNewsFoto/Oxford Gene Technology)

OXFORD, Inglaterra, September 27, 2016 /PRNewswire/ --

Oxford Gene Technology (OGT), The Molecular Genetics Company, ha lanzado sus SureSeq myPanel™ NGS Custom Cancer Panels que proporcionan a los científicos paneles de pruebas personalizados y pre-optimizados de secuenciación de próxima generación (NGS) relevantes para su investigación. La biblioteca completa de contenido de genes cubre los principales tipos de cáncer, incluyendo mieloide, leucemia linfocítica crónica (CLL), de ovarios y mama. Gracias al uso de la captura basada en hibridización, los paneles proporcionan una cobertura complete sin precedentes y uniformidad, actualizándose de forma habitual para conseguir una relevancia máxima de la investigación actual.

     (Logo: http://photos.prnewswire.com/prnh/20160909/406091LOGO )

Los SureSeq myPanel NGS Custom Cancer Panels proporcionan una cobertura completa y uniforme de los genes interesados, incluyendo los que cuentan con un contenido GC elevado. Los investigadores pueden seleccionar pruebas solo para regiones específicas de su interés, pudiendo asegurar la integridad de los datos. Los paneles son más pequeños, están muy personalizados y pre-optimizados permiten además un rendimiento superior y necesitan de un tiempo de validación mínimo. Al tiempo que se añaden nuevas pruebas en OGT tras la consulta con expertos, los paneles pueden sustituirse o añadir con un coste mucho más bajo en comparación con los paneles fijos, asegurando que el paso siguiente de la investigación está sin obstáculos.

Anna Skowronska, científica de investigación y desarrollo del West Midlands Regional Genetics Laboratory que ha ensayado con un panel mieloproliferador neoplasma (MPN), comentó: "Estamos encantados con el rendimiento conseguido con el panel SureSeq. Ha demostrado una concordancia completa con nuestras otras técnicas, detectando todas las mutaciones conocidas con una sensitividad excelente por debajo del 1%, incluyendo en un caso, una mutación JAK2 V617F que no fue detectada por ddPCR debido a una segunda mutación por debajo de la imprimación. El panel demostró además mutaciones en otras muestras de genes con un bajo nivel JAK2 V617F y una buena correlación entre las frecuencias de alelos y el análisis cuantitativo por ddPCR. Estamos planeando adoptar este panel dentro de un futuro cercano".

David Cook, responsable de productos senior de OGT, explicó: "Nuestros SureSeq myPanel NGS Custom Cancer Panels permiten a los investigadores elegir y seleccionar de forma sencilla las pruebas que encajan en sus requisitos específicos y actualizar el panel con nuevo contenido, tal y como se necesita. Nuestro compromiso con la I+D en marcha significa que el contenido se actualizará de forma regular, y para las áreas de interés específicas no disponibles aún, los clientes podrán solicitar que se desarrollen y reciban un panel completamente personalizado con pruebas pre-optimizadas en tan solo unas semanas".

Si desea conocer más visite la página web http://www.ogt.com/sureseq.

SureSeq™: Solo para uso de investigación; no para uso en procedimientos de diagnosis.   

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