Paradigm Health Announces Oncology and Healthcare Expert Dr. Karen E. Knudsen Appointed to Board of Directors and Launch of New AI-Driven Solution for Clinical Trial Data Collection and Management

COLUMBUS, Ohio, March 20, 2025 /PRNewswire/ -- Paradigm Health, which is rebuilding the clinical research ecosystem, today announced the appointment of Karen E. Knudsen, MBA, PhD, to its Board of Directors, alongside the upcoming launch of its eSource clinical trial data application.

Dr. Knudsen is a globally recognized cancer scientist and executive leader who joins Paradigm Health's board following a successful term as Chief Executive Officer of the American Cancer Society (ACS) and its advocacy affiliate, ACS Cancer Action Network. She brings extensive expertise around the challenges and opportunities in clinical research to this Board appointment.

"Having led a National Cancer Institute-designated cancer center and oncology team across a 16-hospital, two-state system, I've witnessed firsthand how administrative burden limits clinical trial capacity," said Dr. Knudsen. "Paradigm Health's technology-driven approach addresses one of healthcare's most persistent challenges: bringing trials to where patients live. Doing so will help expand who has access to trials and improve data so we know that new treatments will work for the populations they're designed to treat. Supporting Paradigm Health aligns with my career-long focus on expanding access to innovative care options."

Dr. Knudsen previously served as EVP of Oncology Services for Jefferson Health and Enterprise Director of the Sidney Kimmel Comprehensive Cancer Center, a National Cancer Institute (NCI)-designated center of excellence. She has served on the NCI Board of Scientific Advisors and as President of the Association of American Cancer Institutes. She has been a professor at Thomas Jefferson University for over seventeen years, now serving as Professor Emerita.

"Karen is one of the most respected voices in oncology research and patient advocacy and a leader in the movement to make clinical trials more economic and efficient," said Kent Thoelke, founder and CEO of Paradigm Health. "Her experience guiding organizations through transformative growth will complement our mission to expand clinical trial access to every patient, everywhere."

Robert Nelsen, co-founder and managing director of ARCH Venture Partners and Paradigm Health Board of Directors chair, commented, "With Karen's exceptional career and focus on accelerating cancer care and access for patients, she is a great addition to the Paradigm Health Board of Directors. She will help us drive accessibility to clinical trials at scale using the Paradigm Health platform to achieve the mission of making clinical trials a care option for all patients, while lowering costs and maximizing drug development efficiency."

New Solution from Paradigm Health Promises to End Redundant Manual Clinical Trial Data Entry

Paradigm Health is also announcing the upcoming launch of eSource Casebook, the first application in the Study Conduct solution suite, which automates the end-to-end process of capturing and auditing clinical trial data. Today this process requires thousands of hours of manual labor for each trial, from physician, nurses, and research coordinators. With eSource Casebook, clinical teams enter data once in the patient's electronic medical record (EMR) and Paradigm Health uses an LLM-based approach to automatically populate and transmit data to the sponsor, reducing both data entry and data auditing burden.

"Seeing eSource Casebook in action was a lightning bolt moment," said Knudsen. "Today's infrastructure forces provider research teams into an exhausting cycle of finding and documenting patient information in their EMR, only to re-enter nearly identical details into trial-specific electronic data capture systems. This redundant, manual process is not only time-consuming but also incredibly resource-draining. It's followed by costly, labor-intensive audits to ensure data accuracy. From my experience, these inefficiencies place an overwhelming burden on providers, stretching their resources thin, creating friction between stakeholders, and ultimately preventing them from considering new research opportunities. In past roles, I would have loved access to a tool that alleviates this pressure, bringing interoperability and data accuracy while saving time and reducing costs. eSource Casebook does just that."

Today there is an eight-day average delay from patient clinical visit to study data entry, a gap driven by overburdened healthcare provider staff and overwhelming levels of manual data entry. Paradigm Health's eSource Casebook solution is an EMR-integrated application that extracts trial-specific data from the EMR (including structured and unstructured data), autopopulates electronic clinical report forms (eCRFs), and seamlessly pushes the information in the appropriate format to the trial sponsor's electronic data capture (EDC) systems.

Paradigm Health CEO Kent Thoelke commented, "Historically, clinical trials have been constrained by an organization's capacity for data entry, with medical progress held back due to a lack of people at keyboards transferring critical information from one system to another. Paradigm Health's eSource Casebook makes this transfer automatic and seamless. It's another way we're attacking the inefficiencies in clinical trials. By incorporating the most current LLMs to read, structure, derive knowledge, and quality check trial data we'll save thousands of hours and help make it possible to run clinical trials in far more locations, even where support resources are limited."

Organizations interested in the April release of eSource Casebook can learn more by contacting the Paradigm Health team at https://www.paradigm.inc/contact.

About Paradigm Health

Paradigm Health is rebuilding the clinical research ecosystem by creating a platform that enables equitable access to trials for all patients, while enhancing trial efficiency and reducing the barriers to participation for healthcare providers. The company's platform integrates within health systems and partners with sponsors to make every trial more intelligent, impactful, and better for patients. For more information, please visit www.paradigm.inc.

Paradigm Health's platform and services are currently deployed at over 400 research sites across 1,000 healthcare provider locations. The company has demonstrated significant results in expanding trial access, including tripling patient enrollment in clinical trials at rural health systems.

SOURCE Paradigm Health, Inc.