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Perceptive Discovery and Pfizer Launch the Groundbreaking FIBRE Consortium to Transform Fibrosis Drug Development


News provided by

Perceptive Discovery

Jun 20, 2025, 09:44 ET

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NEEDHAM, Mass., June 20, 2025 /PRNewswire/ -- Perceptive Discovery, a global leader in molecular and functional imaging research, today announced the launch of the FIBRE (Fibrosis Imaging Biomarker Research & Evaluation) Consortium, a bold pre-competitive collaboration with Pfizer, Lantheus, and Lumina Pharmaceuticals. This pioneering initiative aims to revolutionize the treatment of multi-organ fibrotic diseases by advancing cutting-edge imaging biomarkers to accelerate the development of life-changing therapies.

The FIBRE Consortium brings together world-class expertise in drug development and advanced imaging to address a significant and growing unmet medical need. By leveraging Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI), the consortium aims to identify and validate early disease biomarkers, streamlining and optimizing the development of disease-modifying therapies for fibrosis. All studies will be conducted at the Perceptive Discovery London Imaging Center, ensuring the highest standards in data acquisition and imaging analysis.

Initial studies will focus on Metabolic Dysfunction-Associated Steatohepatitis (MASH), with potential future expansion into other fibrotic conditions. Imaging research will evaluate tracers targeting Fibroblast Activation Protein (FAP) and Collagen Type I in both patients and healthy volunteers to detect biomarkers of early disease progression.

"Fibrotic diseases are progressive and debilitating, with a pressing need for therapies that can truly modify the course of the disease," said Eugenii A. Rabiner, EVP and Global Head of Translational Applications at Perceptive Discovery. "Molecular and functional imaging biomarkers offer a powerful way to transform early-phase drug development—enabling more precise decisions, reducing trial size and cost, and increasing the likelihood of success in bringing new therapies to the patients who need them most."

The FIBRE Consortium also represents a major step toward standardizing care for fibrotic diseases by promoting cross-sector collaboration and shared data. Inspired by the success of MIND MAPS (Molecular Imaging in Neurodegeneration – Mitochondria, Associated Proteins, and Synapses), a previous collaboration between Perceptive Discovery, Pfizer and other leading pharma / academic collaborators, FIBRE is designed to expand cross-disease biomarker research and attract new biotech and pharmaceutical partners. Each new member will have the opportunity to lead disease-specific cohort studies and contribute to a growing foundation of knowledge shaping the future of fibrosis treatment.

Lantheus, the leading radiopharmaceutical-focused company committed to enabling clinicians to Find, Fight and Follow disease to deliver better patient outcomes, will supply the precursor to its PET imaging agent targeting FAP (LNTH-1363S), which will be radiolabeled with 18F by Perceptive for clinical research use in the FIBRE consortium studies. FAP is a membrane-bound dipeptidyl peptidase that is selectively expressed in activated fibroblasts during the development and progression of fibrosis.

Lumina Pharmaceuticals, a clinical-stage pharmaceutical company, will contribute [⁶⁸Ga]CBP8, a tracer targeting Collagen Type I, the dominant collagen type produced during pathological fibrosis. [⁶⁸Ga]CBP8 PET imaging has been shown to quantify pulmonary fibrosis in patients and measure collagen changes over time or in response to therapeutic intervention.

For more information about the FIBRE Consortium or to explore partnership opportunities, please contact us at [email protected] or visit www.fibreconsortium.com.

SOURCE Perceptive Discovery

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