Ponce De Leon Health Announces Results Of Pilot Research Suggesting That Biological Age Can Be Reduced In Humans

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Jun 29, 2020, 05:00 ET

FERNANDINA BEACH, Fla., June 29, 2020 /PRNewswire/ -- Ponce De Leon Health, Inc. ("Ponce de Leon"), a longevity company focused on reversing epigenetic aging, today announced the results of pilot research suggesting that Rejuvant® LifeTabs®, reduced the biological age of customers by an average of 8.5 years. The biological age was assessed by way of a DNA biomarker test that measures DNA methylation. Of the subjects in the analysis, two-thirds showed a statistically significant reduction in biological age. The analysis was based on data from subjects who had taken Rejuvant LifeTabs for a period of four to six months. Rejuvant, a dietary supplement, is Ponce de Leon's first commercial product.

The data were independently compiled by Dr. Yelena Budovskaya, Ph.D., co-founder and lead scientist of TruMe Labs, a pioneer in the emerging field of epigenetic aging testing. Ponce de Leon is a distributor of TruMe's TruAge Index, a take-at-home, non-invasive epigenetic age test. The subjects included in the analysis represent all 17 customers who had taken a TruAge test at the time of their first purchase of Rejuvant, as well as a second test after taking the supplement for four to six months. The TruAge Index measures DNA methylation, which is growing in acceptance by longevity researchers as an important biomarker of biological aging.

All formulations of LifeTabs contain the proprietary active ingredient LifeAKG™, which was shown in recent pre-clinical animal studies to increase lifespan (the length of life) and healthspan (the length of healthy life) in mammalian models. Ponce de Leon has eight patents pending for inventions arising from its research and development activities.

Ponce De Leon is currently enrolling participants for a larger, randomized, double-blind, placebo-controlled clinical trial, to be conducted at Indiana University Medical Center later this year.

The Company's Chief Medical Officer, Francis R. Palmer, M.D., stated that "although at this stage we only have consumer data, these findings are very promising. We are only aware of one other published trial where researchers were able to show a reduction in biological age in humans as measured by DNA methylation. In this other trial, modest reductions in biological age were observed in a small number of subjects who were treated with a combination of prescription drugs for a year. The Rejuvant results are suggestive at this time but it showed a greater average reduction in biological age, achieved in six months, using non-prescription compounds." Added Palmer, "we expect our human clinical trial results to corroborate the encouraging data we have now, and we believe this will have a meaningful impact on both the scientific and consumer communities."

The Company's CEO and Founder, Tom Weldon, commented "the pilot research data appears to be consistent with our earlier mammal results but we appreciate the need for a more robust study to validate this data on lifespan and healthspan research. We look forward to conducting that study later this year and adding to these positive findings. The potential for Rejuvant to reverse epigenetic aging, as measured by DNA methylation testing and other measurable biological markers, may profoundly benefit not only the individuals who take the product, but also the economies and societies in which they participate and live."

Please see www.Rejuvant.com for more information on the groundbreaking science in LifeTabs.

About Ponce De Leon Health
Ponce De Leon Health (www.PDLHealth.com) is a commercial-stage company focused on reversing epigenetic aging. Their work focuses on novel use of a combination of commonly used food ingredients developed independently by the world's leading non-profit institute studying aging. Their goal is to increase human healthspan, improve quality of life, and reduce the cost of providing late stage health care to customers. Their inaugural product, Rejuvant® LifeTabs®, is available at www.Rejuvant.com. You can also learn more about Rejuvant on Facebook, Twitter, and YouTube.

SOURCE Ponce De Leon Health