Research links gene variants to medication-induced fatal brain infection

Results published in Frontiers in Neurology may lead to an 11% reduction in PML caused by immune-modifying medications

NEWPORT BEACH, Calif., Dec. 14, 2022 /PRNewswire/ --New research has confirmed a strong link between four genetic mutations and progressive multifocal leukoencephalopathy (PML), a rare but often fatal brain infection that can be triggered by dozens of FDA-approved drugs.

The research, published in Frontiers in Neurology on December 14, will allow doctors to screen out patients with the highest risk of PML.

The study found that in people taking PML-inducing drugs, having one of four genetic variants increased the risk of PML 8.7 times on average. One of the variants increased risk 33-fold.

Eight medications carry a Black Box Warning for PML, the strongest warning the FDA gives. More than 30 additional drugs carry other PML warnings. In total, PML cases have been reported to the FDA in patients on more than 75 drugs. The list includes many of the most effective treatments for multiple sclerosis (MS), blood cancers, rheumatoid arthritis, Crohn's disease, and organ transplant rejection.  

PML is caused by the JC virus (JCV), a generally harmless virus carried by up to 80% of the population. PML occurs when the virus reactivates and attacks the brain with life-threatening consequences. Researchers have long been searching for an explanation for why the virus leads to PML in some people but not others.

In this study, researchers first demonstrated that four genetic variants were far more common in patients who developed drug-induced PML than in the general population. They then looked for these variants in the ideal control group: MS patients who carried JCV and were taking a high-risk drug for years, but who did not develop PML. The results were even stronger when compared to these matched controls.    

Nearly 11% of patients with PML tested positive for at least one of the four variants. To put this finding in perspective, these variants explain a higher percentage of PML cases than the well-known BRCA mutations explain breast cancer cases. Additionally, their predictive power exceeds levels that have led the FDA to require genetic screening for other risky medications.

Drug-induced PML is on the rise as more immunosuppressant therapies are developed. In 2021, there were more than 500 cases in the FDA's adverse event reporting system. These drugs are broadly prescribed: in the U.S., nearly 1 million people have MS, another 1.5 million have blood cancers commonly treated with PML-inducing drugs, and 850,000 Americans have received organ transplants.

"It's critical to be able to identify genetic mutations that greatly increase a person's risk of this devastating infection," says Dr. Lawrence Steinman, professor of neurology and neurological sciences, pediatrics, and genetics at Stanford University. His lab developed Tysabri, a powerful MS medication that was temporarily withdrawn from the market because of PML and now carries a Black Box Warning. "Preventative screening for these variants should become part of the standard of care. I wish we had more powerful tools like this for other therapies," he says. Dr. Steinman is not affiliated with this study. 

Another independent PML expert, chief of multiple sclerosis at University of Pennsylvania Perelman School of Medicine and member of the PML Guidelines Committee and lead author of “PML diagnostic criteria: consensus statement from the American Academy of Neurology’s Neuroinfectious Disease Section” Dr. Joseph Berger, says "Determining genetic susceptibility to PML is an extremely promising method of reducing disease risk. A simple inexpensive test may prove revolutionary in this regard."

Link to article: https://www.frontiersin.org/articles/10.3389/fneur.2022.1016377/full

doi: 10.3389/fneur.2022.1016377

This study was funded by Emerald Lake Safety LLC and Population Bio, Inc.

About Emerald Lake Safety

Emerald Lake Safety (ELS) conducts research into the mechanisms behind Serious Adverse Events associated with marketed pharmaceuticals. We conduct clinical and genomic research both on our own and in conjunction with leading academics and scientists from around the world. For more information visit www.emeraldlakesafety.com.

About Population Bio

Population Bio is a precision medicine company with a mission to make pharmaceuticals safer and more effective. By discovering disease-relevant genetic biomarkers, Population Bio develops targeted therapies and companion diagnostics. Population Bio's patented technology platform is currently addressing complex neurological diseases, such as Alzheimer's, Parkinson's, and Autism, as well as women's health conditions such as Endometriosis. For more information visit www.populationbio.com.

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SOURCE Emerald Lake Safety LLC; Population Bio, Inc.