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      Rutgers Cancer Institute of New Jersey and RWJBarnabas Health Demonstrate Innovation in Oncology Through Extensive Hematology/Oncology Data to Be Presented at the 63rd American Society of Hematology Annual Meeting and Exposition

      The institutions' latest advances in hematology/oncology will be showcased through 31 scheduled presentations, including 15 oral presentations

      (PRNewsfoto/Rutgers Cancer Institute of New Jersey and RWJBarnabas Health)

      News provided by

      Rutgers Cancer Institute of New Jersey and RWJBarnabas Health

      Dec 07, 2021, 07:00 ET

      Share this article

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      NEW BRUNSWICK, N.J., Dec. 7, 2021 /PRNewswire/ -- Physician-scientists from Rutgers Cancer Institute of New Jersey and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility, will present expansive new hematology/oncology data from their clinical research program at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition, being held in Atlanta, Georgia (and virtually) from December 11-14, 2021. A total of 31 abstracts have been accepted, with data focusing on the latest surgical and treatment advancements in blood cancers, including pediatric hematology, leukemia, lymphoma and myeloma. Rutgers Cancer Institute, in partnership with RWJBarnabas Health, is New Jersey's only National Cancer Institute-designated Comprehensive Cancer Center.

      "Our dynamic teams of nationally renowned cancer specialists and researchers have a deep and ongoing commitment to innovative research in blood cancers, which we proudly look forward to demonstrating through our vast lineup of data at this year's ASH Annual Meeting and Exposition," said Andrew M. Evens, DO, MSc, FACP, Associate Director for Clinical Services, Rutgers Cancer Institute; System Director of Medical Oncology and Oncology Lead for Combined Medical Group, RWJBarnabas Health, who is also an attending physician at Robert Wood Johnson University Hospital. "RWJBarnabas Health, together with Rutgers Cancer Institute of New Jersey, is dedicated to advancing cancer treatments, patient care and ultimately, transforming patient outcomes, with the goal of one day eradicating the disease," adds Dr. Evens, who is also Associate Vice Chancellor, Clinical Innovation and Data Analytics, at Rutgers Biomedical and Health Sciences.

      Highlights of the accepted abstracts include the following:

      • Current NCCN guidelines recommend 1 of 3 first-line regimens for stage III or IV classical Hodgkin lymphoma (cHL). Data from CONNECT, the first real-world observational survey of physicians, patients and caregivers in cHL was designed to understand the decision-making process when selecting a first-line cHL treatment regimen for stage III or IV cHL, and gain insights into physicians' preferred regimens and factors that influence their treatment choices.
      • Data from a large multicenter real-world evidence analysis of autoimmune (AI) diseases and lymphoma examining the impact of AI diseases on patient outcome across varying lymphoma subtypes, including the role of immunosuppressive medications.
      • Data from a large retrospective real-world evidence study of newly-diagnosed Primary Central Nervous System Lymphoma (PCNSL) patients. Treatment of older patients with PCNSL is challenging due to the prevalence of comorbidities, frailty and complexities with effective delivery of chemotherapy. This study analyzed post-induction treatment patterns and outcomes across 20 U.S. academic centers.
      • Research that revealed Sirt1 as a novel therapeutic target in T-cell Acute Lymphoblastic Leukemia (T-ALL). T-ALL is an aggressive hematological malignancy that affects both children and adults, and 20%-50% of patients show primary resistance or relapse after treatment, and ultimately die from their disease.

      The full list of presentations at this year's ASH Annual Meeting and Exposition follows:

      Oral Presentations

      Abstract and
      Session No.

      Title

      Presentation Date/Time           

      Abstract 50
      (Session 627)

      A Large Multicenter Real-World Evidence
      (RWE) Analysis of Autoimmune (AI)
      Diseases and Lymphoma: Histologic
      Associations, Disease Characteristics,
      Survival, and Prognostication

      Saturday, December 11, 2021, at 9:45 a.m. EST

      Abstract 117

      (Session 905)

      Real-World Treatment Patterns and Clinical,
      Economic, and Humanistic Burden in Triple-
      Class Refractory Multiple Myeloma: Analysis
      of the Connect® Multiple Myeloma (MM)
      Disease Registry

      Saturday, December 11, 2021, at 10 a.m. EST

      Abstract 184
      (Session 905)

      A Multi-Center Retrospective Review of
      COVID-19 Outcomes in Patients with
      Lymphoid Malignancy

      Saturday, December 11, 2021, at 12:45 p.m. EST

      Abstract 160 
      (Session 653)

      Early, Deep, and Durable Responses, and
      Low Rates of Cytokine Release Syndrome
      with REGN5458, a BCMAxCD3 Bispecific
      Monoclonal Antibody, in a Phase 1/2 First-in-
      Human Study in Patients with
      Relapsed/Refractory Multiple Myeloma
      (RRMM)

      Saturday, December 11, 2021, at 12:45 p.m. EST

      Abstract 231 
      (Session 624)

      Frontline Treatment with Single Agent
      Pembrolizumab (PEM) Followed By AVD
      Chemotherapy for Classic Hodgkin
      Lymphoma: Updated Results and Correlative
      Analysis

      Saturday, December 11, 2021, at 2:30 p.m. EST

      Abstract 323

      (Session 636)

      PI3-Kinase Deletion Dysregulates Autophagy
      in HSCs and Promotes Myelodysplasia

      Saturday, December 11, 2021, at 5:00 p.m. EST

      Abstract 357

      (Session 603)

      Pervasive Hypermutation of Super-Enhancer
      Regions Dysregulates Oncogene Expression
      in Diffuse Large B-Cell Lymphoma

      Sunday, December 12, 2021, at 10:00 a.m. EST

      Abstract 455 
      (Session 627)

      High-Grade B-Cell Lymphoma, Not
      Otherwise Specified (HGBL, NOS):
      Characteristics, Treatment, and Outcomes
      from 17 Academic US Centers

      Sunday, December 12, 2021, at 1 p.m. EST

      Abstract 532 
      (Session 627)

      Practice Patterns Pre-CART for Aggressive
      B-Cell Lymphomas: Patient Selection and
      Real World Salvage and Bridging Practices

      Sunday, December 12, 2021, at 5:15 p.m. EST

      Session 605

      Molecular Pharmacology and Drug
      Resistance: Lymphoid Neoplasms: Targeting
      Mitochondrial Survival Pathways

      Monday, December 13, 2021, at 2:45-4:15 p.m. EST

      Abstract 814 
      (Session 623)

      Phase II Study of Venetoclax in Combination
      with Obinutuzumab and Bendamustine in
      Patients with High Tumor Burden Follicular
      Lymphoma As Front Line Therapy
      (PrECOG 0403)

      Monday, December 13, 2021, at 5:15 p.m. EST

      Abstract 878 
      (Session 624)

      Novel Salvage Regimens Lead to Better
      Response and Survival in Relapsed
      Refractory Classic Hodgkin Lymphoma after
      Autologous Stem Cell Transplant

      Monday, December 13, 2021, at 6:30 p.m. EST

      Abstract 884 
      (Session 627)

      Outcomes and Treatment Patterns in Patients
      with Aggressive B-Cell Lymphoma after
      Failure of Anti-CD19 CAR T-Cell Therapy

      Monday, December 13, 2021, at 6:30 p.m. EST

      Abstract 879

      (Session 624)

      Effect of Brentuximab Vedotin Addition to
      Chemotherapy and Prognostic Factors in
      Patients with Relapsed/Refractory Hodgkin
      Lymphoma: A Large Multi-Trial Analysis
      Based on Individual Patient Data

      Monday, December 13, 2021, at 6:45 p.m. EST

      Abstract 917

      (Session 901)

      Grapes: Trivia Game Increases Sickle Cell
      Disease Knowledge in Patients and Providers
      and Mitigates Health Biases

      Monday, December 13, 2021, at 7:15 p.m. EST

      Poster Presentations

      Abstract and
      Session No.

      Title

      Presentation Date/Time           

      Abstract 1460 
      (Session 627)

      Connect® Lymphoma Disease Registry:
      A US-Based, Prospective, Observational Cohort
      Study

      Saturday, December 11, 2021, at 10 a.m. EST

      Abstract 1390 
      (Session 624)

      Classical Hodgkin Lymphoma; Real-World
      Observations from Physicians, Patients, and
      Caregivers on the Disease and Its Treatment
      (CONNECT): Observations of Physicians on
      Treatment and Interim PET-Adapted Regimens

      Saturday, December 11, 2021, 5:30-7:30 p.m. EST

      Abstract 1966 
      (Session 905)

      Classical Hodgkin Lymphoma; Real-World
      Observations from Physicians, Patients, and
      Caregivers on the Disease and Its Treatment
      (CONNECT)—a Cross-Sectional Survey of
      Patients with Stage III or IV Classical
      Hodgkin Lymphoma Compared By Age

      Saturday, December 11, 2021, 5:30-7:30 p.m. EST

      Abstract 1428 
      (Session 627)

      Older Patients with Primary Central Nervous
      System Lymphoma (PCNSL): Real World
      Evidence (RWE) of Prognostication and
      Outcomes with Post-Induction Therapy

      Saturday, December 11, 2021, 5:30-7:30 p.m. EST

      Abstract 1347

      (Session 623)

      Production of Anti-Spike Antibodies in
      Response to COVID Vaccine in Lymphoma
      Patients

      Saturday, December 11, 2021, at 5:30-7:30 p.m. EST

      Abstract 1491

      (Session 634)

      Surpass-ET Trial: A Phase 3, Open-Label,
      Multicenter, Randomized, Active-Controlled
      Study to Assess Pharmacokinetics and
      Compare the Efficacy, Safety, and
      Tolerability of P1101 Vs Anagrelide As
      Second Line Therapy for Essential
      Thrombocythemia

      Saturday, December 11, 2021, at 5:30-7:30 p.m. EST

      Abstract 2213 
      (Session 602)

      The Atlas of Blood Cancer Genomes (ABCG)
      Project: A Comprehensive Molecular
      Characterization of Leukemias and
      Lymphomas

      Sunday, December 12, 2021, 6-8 p.m. EST

      Abstract 2403 
      (Session 621)

      ALK-Negative Anaplastic Large Cell
      Lymphomas Encompass Distinct Subgroups
      Including an ALK-Positive-like Subgroup
      with Favorable Prognosis

      Sunday, December 12, 2021, 6-8 p.m. EST

      Abstract 2457 
      (Session 624)

      A Multi-Institution Analysis of Relapsed
      Lymphoma Occurring during Pregnancy
      Including Pharmacokinetics with Antenatal
      Checkpoint Inhibitor Therapy

      Sunday, December 12, 2021, 6-8 p.m. EST

      Abstract 2467 
      (Session 624)

      Classical Hodgkin Lymphoma; Real-World
      Observations from Physicians, Patients, and
      Caregivers on the Disease and Its Treatment
      (CONNECT): Physician First-Line Treatment
      Preferences for Stage III or IV Classical
      Hodgkin Lymphoma

      Sunday, December 12, 2021, 6-8 p.m. EST

      Abstract 2221 
      (Session 603)

      Sirt1 Is a Novel Therapeutic Target in T-ALL

      Sunday, December 12, 2021, 6-8 p.m. EST

      Abstract 3853 
      (Session 704)

      Real World Evidence (RWE) of Safety,
      Efficacy, and Outcomes of CD19 CAR-T
      Therapy in 20 Patients with Solid Organ
      Transplant (SOT)-Related Post-Transplant
      Lymphoproliferative Disorder (PTLD)

      Monday, December 13, 2021, 6-8 p.m. EST

      Abstract 3407 
      (Session 614)

      Maximal Tolerated Dose Determined for
      Venetoclax in Combination with Liposomal
      Vincristine in Patients with Relapsed or
      Refractory Ph-Negative T-Cell or B-Cell
      Acute Lymphoblastic Leukemia: Results of
      Phase 1 Portion of ECOG-ACRIN EA9152

      Monday, December 13, 2021, 6-8 p.m. EST

      Abstract 3396 
      (Session 614)

      Impact of Age, Body Surface Area, and Body
      Mass Index on Pegaspargase Toxicity and
      Pharmacokinetics: A Report from the DFCI
      ALL Consortium

      Monday, December 13, 2021, 6-8 p.m. EST

      Abstract 3485

      (Session 618)

      Performance of Next Generation Sequencing
      for Minimal Residual Disease Detection for
      Pediatric Patients with Acute Lymphoblastic
      Leukemia: Results from the Prospective
      Clinical Trial DFCI 16-001

      Monday, December 13, 2021, 6-8 p.m. EST

      Abstract 3100

      (Session 114)

      Real-World Experience of Patients with
      Sickle Cell Disease Treated with Voxelotor:
      A Multicenter, Retrospective Study

      Monday, December 13, 2021, 6-8 p.m. EST

      About Rutgers Cancer Institute of New Jersey
      As New Jersey's only National Cancer Institute-designated Comprehensive Cancer Center, Rutgers Cancer Institute, together with RWJBarnabas Health, offers the most advanced cancer treatment options, including bone marrow transplantation, proton therapy, CAR T-cell therapy and complex surgical procedures. Along with clinical trials and novel therapeutics such as precision medicine and immunotherapy – many of which are not widely available – patients have access to these cutting-edge therapies at Rutgers Cancer Institute of New Jersey in New Brunswick, Rutgers Cancer Institute of New Jersey at University Hospital in Newark, as well as through RWJBarnabas Health facilities. To make a tax-deductible gift to support the Cancer Institute of New Jersey, call 848-932-8013 or visit www.cinj.org/giving.

      For journalists – contact:
      Krista Didzbalis 
      Media Relations Assistant 
      908-812-6114
      [email protected]

      For patient appointments/inquiries – contact:
      844-CANCERNJ (844-226-2376)

      SOURCE Rutgers Cancer Institute of New Jersey and RWJBarnabas Health

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