Sciwind Biosciences to present Data from its GLP-1 and GIP Receptor Agonist Programs at The International Liver Congress(TM) EASL 2022

HANGZHOU, China and SAN FRANCISCO, June 8, 2022 /PRNewswire/ -- Sciwind Biosciences Co., Ltd., a clinical-stage biopharmaceutical company focusing on discovering and developing innovative therapies to treat metabolic disease, today announced that two abstracts have been accepted for poster presentations at The International Liver Congress^TM 2022, the Annual Meeting of the European Association for the Studies of the Liver (EASL) taking place June 22-26 in London, United Kingdom. During the meeting, data from a combination study of Sciwind's long-lasting GLP-1 peptide analog XW003 and GIP peptide analog XW017 in an obese mouse model and preclinical pharmacology data for the oral small molecule GLP-1 receptor agonist XW014 will be featured in two poster presentations.

"We are excited to have an opportunity to present the recent data from our GLP-1 and GIP receptor agonist programs at this prestigious international conference," said Xinle Wu, PhD, Chief Scientific Officer of Sciwind. "We believe that these data lend strong support to Sciwnd's long-term strategy to develop more efficacious, better tolerated and more convenient treatment options for patients living with metabolic disease."

Presentation Details:

Poster Title: Synergistic activity of GLP-1 peptide analog XW003 and the long-lasting GIP receptor agonist XW017 in a diet induced obese mouse model
Publication Number: 1391
Session Title: NAFLD: Therapy
Date: Saturday June 25 between 9AM – 6PM GMT
Poster Title: Preclinical pharmacology of low molecular weight GLP-1 receptor agonist XW014
Publication Number: 1399
Session Title: NAFLD: Therapy
Date: Saturday June 25 between 9AM – 6PM GMT

About XW003

Injectable GLP-1 analogs are effective tools in managing type 2 diabetes, obesity, and have demonstrated clinical potential as a treatment for NASH.  XW003 is a novel, biased long-lasting GLP-1 peptide analog optimized for improved biological activity, cost-effective manufacturing, and once weekly dosing. XW003 has been shown to be safe and well tolerated in Phase 1 clinical study. Phase 2 studies are underway to study XW003 as a potential treatment for type 2 diabetes and obesity.

About XW014

XW014 is a small molecule GLP-1 receptor agonist with the potential to be dosed orally once a day. Compared with GLP-1 peptide analogs, this small molecule agonist is easier to manufacture and formulate for oral dosing.   As a small molecule, XW014 has the potential to be co-formulated with other oral drugs of complementary mechanisms to create more effective combination treatments for obesity, type 2 diabetes, and NASH. XW014 is slated to enter clinical trials in Q3 2022.

About XW017

In combination with GLP-1 analogs, injectable GIP receptor agonists have demonstrated improved glycemic control, as well as more profound weight loss, in clinical trials.  XW017 is a novel, long-lasting GIP peptide analog optimized for biological activity and in vivo stability. It has the potential to be co-formulated with GLP-1 analogs to generate more effective combination treatments for obesity, type 2 diabetes, and NASH. XW017 is anticipated to enter clinical trials in 1H 2023.

About Sciwind

Sciwind Biosciences is a clinical stage biopharmaceutical company focusing on discovering and developing innovative therapies to treat metabolic disease. Its product pipeline consists of potentially first-in-class and best-in-class drug candidates. Sciwind has developed multiple proprietary technologies, including oral peptide and inhaled protein therapeutic delivery platforms and identified a series of drug candidates based on these core platform technologies. For more information, visit www.sciwindbio.com.

SOURCE Hangzhou Sciwind Biosciences Co., Ltd.