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Secuenciadores de Oxford Nanopore apoyan la secuenciación rápida de coronavirus
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Oxford Nanopore Technologies

Jan 31, 2020, 13:49 ET

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- Los secuenciadores de Oxford Nanopore han salido de Reino Unido a China, para apoyar la secuenciación rápida de coronavirus cercana a la muestra para la vigilancia del brote  

OXFORD, Inglaterra, 31 de enero de 2020 /PRNewswire/ -- Tras el amplio apoyo de –y colaboración con- los profesionales de la salud pública en China, Oxford Nanopore ha enviado 200 secuenciadores MinION adicionales y productos de consumo relacionados a China. Estos se utilizarán para apoyar la actual vigilancia del actual brote de coronavirus, añadiéndose a un gran número de dispositivos ya instalados en el país.

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700Kg of Oxford Nanopore sequencers and consumables are on their way for use by Chinese scientists in understanding the current coronavirus outbreak.
700Kg of Oxford Nanopore sequencers and consumables are on their way for use by Chinese scientists in understanding the current coronavirus outbreak.
MinION is the only portable, real-time device for DNA and RNA sequencing.
MinION is the only portable, real-time device for DNA and RNA sequencing.
Each MinION sequencer is approximately the size of a stapler, and can provide rapid sequence information about the coronavirus.
Each MinION sequencer is approximately the size of a stapler, and can provide rapid sequence information about the coronavirus.

Oxford Nanopore ya está trabajando para apoyar a los más de 100 laboratorios de salud pública en China, así como a un número de laboratorios de microbiología chinos y científicos de salud pública globales, con una creciente comunidad de científicos participando en el proceso de vigilancia.

"Somos privilegiados de estar trabajando con una comunidad científica global para apoyar su conocimiento de este brote", dijo el doctor Gordon Sanghera, consejero delegado de Oxford Nanopore. "Esperamos que la visión de nanopore de permitir a todo el mundo acceder a la información biológica, en cualquier parte, pueda tener un impacto positivo y estamos inmensamente agradecidos por el apoyo a la comunidad mientras trabajamos para optimizar rápidamente este brote".

El secuenciador MinION se diseñó para una amplia accesibilidad. Pesa menos de 100 gramos y se opera con un portátil o accesorio especial, el MinIT, para realizar el análisis de datos. Reproduce datos de secuencia en tiempo real, permitiendo una rápida secuenciación. Es adecuado para secuenciar rápido en localizaciones distribuidas. Previamente, el dispositivo ha realizado secuenciaciones en entornos rurales o remotos, por ejemplo en el conocimiento de Ébola, el Zika o la tuberculosis.  

"Pudimos generar resultados menos de 24 horas después de recibir una muestra positiva de Ébola, y el proceso de secuenciación nos llevó solo entre 15 y 60 minutos. Mostramos que la vigilancia genómica en tiempo real es posible en entornos de recursos limitados y pueden establecerse para controlar los brotes", dijo Josh Quick, University of Birmingham, Nature, 2016 https://www.nature.com/articles/nature16996

La secuenciación rápida del coronavirus ha sido una herramienta esencial para entender el brote. La información de secuencia se combina típicamente con datos de localización y tiempo para ofrecer una perspectiva de cómo se propaga el virus y si está cambiando.

La tecnología de secuenciación de Oxford Nanopore se ha utilizado en muchos genomas de coronavirus tempranos de China, incluyendo el primer genoma publicado en NEJM y el "núcleo" de genomas que indicaron transmisión de humano a humano que se publicaron en The Lancet y los primeros genomas publicados desde Estados Unidos.

Los investigadores en la comunidad científica han desarrollado protocolos de secuenciación de nanopore de nCoV; Oxford Nanopore está trabajando con la comunidad científica en la optimización de estos protocolos.  

Si está interesado en seguir las novedades en el uso de nanopore en ese brote, siga esta publicación, y si quiere estar en contacto para apoyo específico nCoV, utilice este formulario.

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