Sigma® Life Science Launches Efflux Transporter Knockout Human Cell Lines in a Convenient Assay-Ready Format

Nov 20, 2012, 07:00 ET from Sigma-Aldrich Corporation

ST. LOUIS, Nov. 20, 2012 /PRNewswire/ -- Sigma-Aldrich® Corporation (Nasdaq: SIAL) announced that Sigma Life Science, its innovative biological products and services business, today launched its CompoZr® Transporter Knockout human cell lines in a consumable, assay-ready plate format. The efflux transporter knockout cell lines allow precise identification of individual drug-transporter interactions, a critical component for understanding the safety and efficacy characteristics of drug candidates. For more information on the CompoZr Transporter Knockout Assay-Ready Plates, visit

"By offering our cell lines in a user-friendly format, these plates allow customers to avoid handling and maintenance of cell lines, thus reducing operative costs and time.  Meeting the demands of both the occasional and the high-throughput user, the new format helps to address many of the unmet needs for preclinical ADME screening, safety studies, and new regulatory guidelines in the United States and Europe," said Paul Brooks, Ph.D., Market Segment Manager at Sigma Life Science.

The industry's current assays for drug-transporter interactions use chemical inhibitors, which commonly interact with multiple transporters simultaneously and thus generate ambiguous information. The efflux transporter cell lines consist of three individual knockouts (MDR1, MRP2 and BCRP) and double knockouts (MDR1:MRP2, MDR1:BCRP and MRP2:BCRP) that are delivered to the customer in a convenient transwell plate format. These are ready-to-use in the "gold standard" 21-day monolayer Caco assay for studying efflux characteristics and so allows flexibility in the choice and trial of the efflux transporter knockout cell lines to optimize preclinical screening.

For more information, visit

Cautionary Statement: The foregoing release contains forward-looking statements that can be identified by terminology such as "precise identification," "unambiguous," "easy," or similar expressions, or by expressed or implied discussions regarding potential future revenues from products derived there from. You should not place undue reliance on these statements. Such forward-looking statements reflect the current views of management regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that CompoZr Transporter KO cell lines or related services will assist the Company to achieve any particular levels of revenue in the future. In particular, management's expectations regarding products associated with CompoZr Transporter KO cell lines or related services could be affected by, among other things, unexpected regulatory actions or delays or government regulation generally; the Company's ability to obtain or maintain patent or other proprietary intellectual property protection; competition in general; government, industry and general public pricing pressures; the impact that the foregoing factors could have on the values attributed to the Company's assets and liabilities as recorded in its consolidated balance sheet, and other risks and factors referred to in Sigma-Aldrich's current Form 10-K on file with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those anticipated, believed, estimated or expected. Sigma-Aldrich is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Sigma Life Science: Sigma Life Science is a Sigma-Aldrich business that represents the Company's leadership in innovative biological products and services for the global life science market and offers an array of biologically-rich products and reagents that researchers use in scientific investigation. Product areas include biomolecules, genomics and functional genomics, cells and cell-based assays, transgenics, protein assays, stem cell research, epigenetics and custom services/oligonucleotides. Sigma Life Science also provides an extensive range critical bioessentials like biochemicals, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, amino acids and their derivatives, and cell culture media.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company whose biochemical, organic chemical products, kits and services are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical, diagnostics and high technology manufacturing. Sigma-Aldrich customers include more than 1.3 million scientists and technologists in life science companies, university and government institutions, hospitals and industry. The Company operates in 38 countries and has nearly 9,000 employees whose objective is to provide excellent service worldwide. Sigma-Aldrich is committed to accelerating customer success through innovation and leadership in Life Science and High Technology. For more information about Sigma-Aldrich, please visit its website at

Sigma-Aldrich and Sigma are trademarks of Sigma-Aldrich Co, LLC registered in the US and other countries. CompoZr is a registered trademarks of Sigma-Aldrich Co. LLC.

SOURCE Sigma-Aldrich Corporation