• Resources
  • Blog
  • Journalists
  • Log In
  • Sign Up
  • Data Privacy
  • Send a Release
Cision PR Newswire: news distribution, targeting and monitoring home
  • News
  • Products
    • Overview
    • Distribution by PR Newswire
    • Cision Communications Cloud®
    • Cision IR
    • All Products
  • Contact
    • General Inquiries
    • Request a Demo
    • Editorial Bureaus
    • Partnerships
    • Media Inquiries
    • Worldwide Offices

 

When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All News Releases
      • All Public Company
      • English-only
      • News Releases Overview

      • Multimedia Gallery

      • All Multimedia
      • All Photos
      • All Videos
      • Multimedia Gallery Overview

      • Trending Topics

      • All Trending Topics
  • Business & Money
      • Auto & Transportation

      • All Automotive & Transportation
      • Aerospace, Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads and Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking and Road Transportation
      • Auto & Transportation Overview

      • View All Auto & Transportation

      • Business Technology

      • All Business Technology
      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • Business Technology Overview

      • View All Business Technology

      • Entertain­ment & Media

      • All Entertain­ment & Media
      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • Entertain­ment & Media Overview

      • View All Entertain­ment & Media

      • Financial Services & Investing

      • All Financial Services & Investing
      • Accounting News & Issues
      • Acquisitions, Mergers and Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalization
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • Financial Services & Investing Overview

      • View All Financial Services & Investing

      • General Business

      • All General Business
      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls and Research
      • Trade Show News
      • General Business Overview

      • View All General Business

  • Science & Tech
      • Consumer Technology

      • All Consumer Technology
      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • Consumer Technology Overview

      • View All Consumer Technology

      • Energy & Natural Resources

      • All Energy
      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil and Gas Discoveries
      • Utilities
      • Water Utilities
      • Energy & Natural Resources Overview

      • View All Energy & Natural Resources

      • Environ­ment

      • All Environ­ment
      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • Environ­ment Overview

      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • All Heavy Industry & Manufacturing
      • Aerospace & Defense
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation and Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking and Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • Heavy Industry & Manufacturing Overview

      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • All Telecomm­unications
      • Carriers and Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • Telecomm­unications Overview

      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • All Consumer Products & Retail
      • Animals & Pets
      • Beers, Wines and Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics and Personal Care
      • Fashion
      • Food & Beverages
      • Furniture and Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewelry
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • Consumer Products & Retail Overview

      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • All Entertain­ment & Media
      • Advertising
      • Art
      • Books
      • Entertainment
      • Film and Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • Entertain­ment & Media Overview

      • View All Entertain­ment & Media

      • Health

      • All Health
      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • Health Overview

      • View All Health

      • Sports

      • All Sports
      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • Sports Overview

      • View All Sports

      • Travel

      • All Travel
      • Amusement Parks and Tourist Attractions
      • Gambling & Casinos
      • Hotels and Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • Travel Overview

      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • All Policy & Public Interest
      • Advocacy Group Opinion
      • Animal Welfare
      • Congressional & Presidential Campaigns
      • Corporate Social Responsibility
      • Domestic Policy
      • Economic News, Trends, Analysis
      • Education
      • Environmental
      • European Government
      • FDA Approval
      • Federal and State Legislation
      • Federal Executive Branch & Agency
      • Foreign Policy & International Affairs
      • Homeland Security
      • Labor & Union
      • Legal Issues
      • Natural Disasters
      • Not For Profit
      • Patent Law
      • Public Safety
      • Trade Policy
      • U.S. State Policy
      • Policy & Public Interest Overview

      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • All People & Culture
      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • People & Culture Overview

      • View All People & Culture

      • In-Language News

      • español
      • português
      • Česko
      • Danmark
      • Deutschland
      • España
      • France
      • Italia
      • Nederland
      • Norge
      • Polska
      • Portugal
      • Россия
      • Slovensko
      • Suomi
      • Sverige
  • Overview
  • Distribution by PR Newswire
  • Cision Communications Cloud®
  • Cision IR
  • All Products
  • General Inquiries
  • Request a Demo
  • Editorial Bureaus
  • Partnerships
  • Media Inquiries
  • Worldwide Offices
  • PR Newswire: news distribution, targeting and monitoring
  • Send a Release
    • ALL CONTACT INFO
    • Contact Us

      888-776-0942
      from 8 AM - 10 PM ET

  • Send a Release
  • Sign Up
  • Log In
  • Resources
  • Blog
  • Journalists
  • RSS
  • GDPR
  • News in Focus
    • Browse All News
    • Multimedia Gallery
    • Trending Topics
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Send a Release
  • Sign Up
  • Log In
  • Resources
  • Blog
  • Journalists
  • RSS
  • GDPR
  • Overview
  • Distribution by PR Newswire
  • Cision Communications Cloud®
  • Cision IR
  • All Products
  • Send a Release
  • Sign Up
  • Log In
  • Resources
  • Blog
  • Journalists
  • RSS
  • GDPR
  • General Inquiries
  • Request a Demo
  • Editorial Bureaus
  • Partnerships
  • Media Inquiries
  • Worldwide Offices
  • Send a Release
  • Sign Up
  • Log In
  • Resources
  • Blog
  • Journalists
  • RSS
  • GDPR

The BBVA Foundation Frontiers of Knowledge Award in Basic Sciences goes to Stephen Buchwald for creating more efficient, stable, broad-spectrum catalysts of importance in drug discovery

- The third category decided in seventh annual awards

- Buchwald, a professor at MIT, was engaged in purely basic research, when the pharmaceutical industry awakened him to the potential of his work for obtaining carbon-carbon and carbon-nitrogen bonds, a project he would see through to fruition

- The catalysts he constructed with palladium and copper are now being used to synthesize novel molecules of interest in diseases like cancer, AIDS, rheumatoid arthritis and diabetes

- In the ten years from 1999 to 2009 he was the world's most cited chemist per paper, with an h-index of 123


News provided by

BBVA

Jan 20, 2015, 10:24 ET

Share this article

Share this article


MADRID, Jan. 20, 2015 /PRNewswire/ -- The seventh annual BBVA Foundation Frontiers of Knowledge Award in Basic Sciences has gone to U.S. chemist Stephen Buchwald "for the development of catalytic routes based on palladium and copper to construct carbon-nitrogen and carbon-carbon bonds," an advance with "great impact" on the "efficient synthesis of modern pharmaceuticals and compounds for agricultural use," in the words of the prize jury.

The chemistry enabled by the achievements of Stephen Buchwald, a professor at Massachusetts Institute of Technology (MIT), "is now being applied to the creation of drugs for numerous diseases including many forms of cancer, AIDS, rheumatoid arthritis, inflammation and diabetes," the citation continues.

If a chemist's work is largely about adding implements to a "toolbox" with which to construct new compounds, then Buchwald's addition would be the catalysts for forming carbon-nitrogen and carbon-carbon bonds. These bonds, carbon-nitrogen particularly, are in wide use in the pharmaceutical industry, but before Buchwald's contribution, it was extremely hard to obtain them systematically due to the instability and limitations of the catalysts available.

Every chemical reaction requires a certain activation energy. What catalysts do is modify this activation energy by boosting or inhibiting it, which alters the reaction speed. The catalysts that Buchwald created in the first decade of the 21st century lower activation energy so the reaction happens much faster but also in a more stable, predictable way. They also span a broad spectrum of reactivity, making them highly effective instruments for the industrial production of molecules.

Organometallic catalysts consist of a ligand, formed by organic molecules, and a metal center, in Buchwald's case palladium or copper. As jury secretary Avelino Corma explains, "what we now call the Buchwald ligand is electron-rich and air-stable, yielding a highly active organometallic catalyst with a wide spectrum of reactivity. Its stability, moreover, facilitates production at an industrial scale."

Stephen Buchwald (1955, Indiana, United States) declared himself "very excited" yesterday on receiving the news at his desk at MIT. Chemistry, he relates, was "a challenge" that he "fell in love with" thanks to the enthusiasm of a high school teacher. It is a science in which he sees "fundamental but also practical aspects, because if you get some success, your results can find applications in widely different areas." 

Success has not eluded him, and he admits that it is vastly encouraging to see the products, pharmaceuticals especially, that have been manufactured thanks to his research: "It is thrilling to know that someone has used my work to make a drug that will help many people."

At the same time he acknowledges that what attracted him to research was the fundamental rather than the applied side. Buchwald completed a degree in chemistry at Brown University then went on to earn a PhD from Harvard in 1982. His thesis work, with Jeremy R. Knowles, concerned the mechanism of phosphoryl transfer reactions in chemistry and biochemistry. And his postdoctoral research at the California Institute of Technology (Caltech) was also of a basic nature.

In 1984, he joined the faculty at MIT, where he rose to a professorship in 1993. It was in this last year that he initiated a line of work with a more applied focus, exploring the formation of carbon-nitrogen bonds. Gradually this new research took up more and more of the lab's time, eventually becoming what is so far the crowning achievement in Buchwald's career, though he still likes to maintain "a balance" in his group between more fundamental and applied work.

The source of the change was the interest shown by the pharmaceutical industry in one of his basic outcomes: "They explained to me how pressing the need was [to be able to form carbon-nitrogen bonds], so we understood this was something important, and put a growing effort into the project."

In this competitive field, he credits the members of his group with contributing to a house method where each idea is experimentally tested and modified in consequence until arriving at the "optimal system".

The ligand in the catalyst for the carbon-nitrogen bond was some seven years in development, and that of the carbon-carbon bond a little less. For Buchwald, though, the challenge is still not over. His latest work is focused on carbon-fluorine and carbon-trifluoromethyl bonds, "further expanding the possibilities for making new molecules," the citation concludes.

Buchwald is the co-author of over 420 papers in international journals and 44 issued patents. In 1999-2009 he was the chemist with the highest number of citations per paper, attaining an h-index of 123.

A member of the American Academy of Arts and Sciences and the U.S. National Academy of Science, his career accomplishments have been further recognized by the Award for Creative Work in Synthetic Organic Chemistry and Award in Organometallic Chemistry of the American Chemical Society (ACS), the Linus Pauling Medal and the MERIT award of the National Institutes of Health.

About the BBVA Foundation Frontiers of Knowledge Awards

The BBVA Foundation promotes, funds and disseminates world-class scientific research and artistic creation, in the conviction that science, culture and knowledge in its broadest sense hold the key to a better future for people. The Foundation designs and implements its programs in partnership with leading scientific and cultural organizations in Spain and abroad, striving to identify and prioritize those projects with the power to move forward the frontiers of the known world.

The BBVA Foundation established its Frontiers of Knowledge Awards in 2008 to recognize the authors of outstanding contributions and radical advances in a broad range of scientific, technological and artistic areas congruent with the knowledge map of the late 20th and 21st centuries, and others that address central challenges, such as climate change and development cooperation, deserving of greater social visibility and recognition.

Their eight categories include classical areas like Basic Sciences (Physics, Chemistry and Mathematics) and Biomedicine, and other, more recent areas characteristic of our time, ranging from Information and Communication Technologies, Ecology and Conservation Biology, Climate Change and Economics, Finance and Management to Development Cooperation and the innovative realm of artistic creation that is Contemporary Music.

The juries in each category are made up of leading international experts in their respective fields, who arrive at their decisions in a wholly independent manner, applying internationally recognized metrics of excellence. The BBVA Foundation is aided in the organization of the awards by the Spanish National Research Council (CSIC), the country's premier multidisciplinary research body. As well as designating each jury chair, the CSIC is responsible for appointing the Technical Evaluation Committees that undertake an initial assessment of candidates and draw up a reasoned shortlist for the consideration of the juries.

Committee members in the Basic Sciences category were Juan Manuel Garcia Ruiz, CSIC Research Professor at the University of Granada; Laura Lechuga Gomez, Research Professor in the Center for Research on Nanoscience and Nanotechnology (CSIC); Rosa Menendez Lopez, Research Professor in the National Carbon Institute (CSIC); and Francisco Javier Rojo Marcos, Senior Scientific Researcher in the Institute for Chemical Research (CSIC-University of Sevilla).

Basic Sciences jury (Physics, Chemistry and Mathematics)

The jury in this category was chaired by Theodor W. Hansch, Carl Friedrich von Siemens Chair in the Faculty of Physics at LMU Munich (Germany) and 2005 Nobel Physics Laureate. The secretary was Avelino Corma, Research Professor in the Department of Catalysts, Instituto de Tecnologia Quimica, CSIC-Universidad Politecnica de Valencia (Spain). Remaining members were Ignacio Cirac, Director of the Theory Division at the Max Planck Institute of Quantum Optics (Germany); Trevor Hastie, John A. Overdeck Professor of Mathematical Sciences at Stanford University (United States); Nigel Hitchin, Savilian Professor of Geometry at the University of Oxford (United Kingdom); Martin Quack, Head of the Molecular Kinetics and Spectroscopy Group at ETH Zurich (Switzerland); and Sandip Tiwari, Charles N. Mellowes Professor of Engineering at Cornell University (United States).

Previous laureates

The winners in the last edition were Maximilian Haider, Harald Rose and Knut Urban (Germany) for "greatly enhancing the resolving power of electron microscopy by developing aberration-corrected electron optics, a breakthrough enabling subatomic precision."

The award in the fifth edition was shared by mathematicians Ingrid Daubechies (Belgium) "for her work on wavelets and her leadership in data compression, with a strong impact on technologies supporting efficient audio and video transmission" and David Mumford (United States), "for his contributions to algebraic geometry and to the mathematics of computer vision." Preceding them were Swiss astrophysicists Michel Mayor and Didier Queloz "for their pathbreaking development of new astronomical instruments and experimental techniques that led to the observation of planets outside the solar system." The award in the third edition was granted to Gabor A. Somorjai, "for his pioneering experimental and conceptual contributions to the understanding of surface chemistry and catalysis at a microscopic and molecular level." Richard Zare and Michael Fisher were joint winners in the second edition for their contributions to describing the world at molecular level. Finally, the winners in the inaugural year were physicists Ignacio Cirac and Peter Zoller for their contributions to quantum information science.

UPCOMING AWARD ANNOUNCEMENTS

CATEGORY

DATE

Biomedicine

January 27, 2015

Ecology and Conservation Biology

February 3, 2015

Contemporary Music

February 10, 2015

Economics, Finance and Management

February 17, 2015

Development Cooperation

February 24, 2015

 

SOURCE BBVA

Modal title

Contact Cision

  • Cision Distribution 888-776-0942
    from 8 AM - 9 PM ET

  • Chat with an Expert
  • General Inquiries
  • Request a Demo
  • Editorial Bureaus
  • Partnerships
  • Media Inquiries
  • Worldwide Offices

Products

  • Cision Communication Cloud®
  • For Marketers
  • For Public Relations
  • For IR & Compliance
  • For Agency
  • For Small Business
  • All Products

About

  • About PR Newswire
  • About Cision
  • Become a Publishing Partner
  • Become a Channel Partner
  • Careers
  • COVID-19 Resources
  • Accessibility Statement
  • Asia
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Israel
  • Italy
  • Mexico
  • Middle East
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United Kingdom

My Services

  • All New Releases
  • Online Member Center
  • ProfNet

Contact Cision

Products

About

My Services
  • All News Releases
  • Online Member Center
  • ProfNet
Cision Distribution Helpline
888-776-0942
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2022 Cision US Inc.