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Una asombrosa investigación sobre tumores cerebrales gana el Premio BIAL de Biomedicina 2023
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Feb 21, 2024, 03:00 ET

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PORTO, Portugal, 21 de febrero de 2024 /PRNewswire/ -- Un equipo de investigadores de Alemania, EE.UU., Reino Unido y Noruega ganó la tercera edición del Premio BIAL en Biomedicina, un premio dotado con 300.000 euros impulsado por la Fundación BIAL, que busca reconocer un trabajo publicado en los últimos 10 años en el campo de la biomedicina de excepcional calidad y relevancia científica.

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Lead researchers of the winning team of the BIAL Award in Biomedicine 2023 promoted by the BIAL Foundation. Photo credits: Thomas Kuner - Hendrik Schröder, Heidelberg University Hospital; Frank Winkler - berlin-event-foto.de; Varun Venkataramani - Carina Kircher and Gerald Bendner.
Lead researchers of the winning team of the BIAL Award in Biomedicine 2023 promoted by the BIAL Foundation. Photo credits: Thomas Kuner - Hendrik Schröder, Heidelberg University Hospital; Frank Winkler - berlin-event-foto.de; Varun Venkataramani - Carina Kircher and Gerald Bendner.

Dirigido por los investigadores Varun Venkataramani (primer autor), Frank Winkler y Thomas Kuner (coautores principales) de la Universidad de Heidelberg en Alemania, el estudio "La entrada sináptica glutamatérgica a las células de glioma impulsa la progresión del tumor cerebral", publicado en Nature en 2019, representa una investigación innovadora importante para comprender el cáncer humano, específicamente los glioblastomas, un tipo de tumor cerebral muy agresivo con un tiempo de supervivencia promedio de solo 1,5 años, incluso con el tratamiento más moderno.

En este trabajo, los autores demostraron que los glioblastomas y otros gliomas incurables pueden integrarse en la función del cerebro y que la información procedente de células cerebrales sanas, normalmente utilizadas en funciones como el pensamiento y la memoria, impulsa la progresión de los gliomas. Esto es posible gracias a la formación de sinapsis entre las neuronas y las células cancerosas.

Para el presidente del jurado, "estos hallazgos suponen un avance importante y sorprendente en la comprensión de cómo progresa el cáncer de cerebro, al describir un nuevo canal de comunicación entre las neuronas y el tumor y al sugerir vías de tratamiento específicas".

Este artículo muestra que las células cancerosas no pueden simplemente proliferar: tienen que secuestrar procesos biológicos saludables e integrarse en la función normal de los tejidos. "En ningún lugar esto es más evidente y sorprendente que en los tumores cerebrales estudiados en este artículo", afirmó Ralph Adolphs.

La investigación galardonada también proporciona una nueva explicación de por qué la epilepsia y la progresión del tumor a menudo se observan juntas: la epilepsia puede ser una causa, más que una consecuencia de la progresión del tumor.

El artículo ganador, elegido entre 70 nominaciones, tiene como coautores 29 investigadores de la Universidad de Heidelberg, el Hospital Universitario de Heidelberg, el Centro Alemán de Investigación del Cáncer, el Hospital Universitario de Mannheim, la Universidad Otto-von-Guericke (Alemania), la Facultad de Medicina de la Universidad Johns Hopkins (EE.UU.), la Universidad de Glasgow (Reino Unido), la Universidad de Bergen y el Hospital Universitario de Haukeland (Noruega).

Cabe señalar que dos de los científicos ganadores de la edición 2021 de este Premio, Katalin Karikó y Drew Weissman, fueron galardonados con el Premio Nobel de Fisiología o Medicina 2023 por sus descubrimientos que permitieron desarrollar vacunas basadas en ARNm para prevenir el COVID-19.

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