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      耶魯大學醫學院獲 1,000 萬美元補助,啟動發炎研究計畫

      Yale School of Medicine Logo

      News provided by

      Yale School of Medicine

      Oct 30, 2026, 09:26 ET

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      康乃狄克州紐哈芬 2026年10月30日 /美通社/ -- 耶魯大學醫學院(Yale School of Medicine,YSM)獲得 Blavatnik Family Foundation(BFF)提供的 1,000 萬美元補助,將啟動發炎科學領域的全新研究計畫。這筆捐款將推動耶魯大學醫學院的一項重點發展目標,支持科學家探索發炎在人類健康與疾病中的作用。同時,還將提供研究生與博士後研究人員獎助金。

      「我們感謝 Blavatnik Family Foundation 的遠見與慷慨支持。」耶魯大學醫學院 Jean and David W. Wallace 冠名院長 Nancy J. Brown(醫學博士)表示。「發炎幾乎是當今各種疾病的共同基礎,釐清發炎在健康與疾病中的機制,有望為未來世代的醫學帶來變革。這筆補助將聚焦於健康與疾病狀態下免疫系統發育的基本機制。」

      這筆補助將專門用於理解調控發炎的基本原理。發炎性疾病發生於免疫系統誤傷健康組織時,這會導致慢性發炎,而慢性發炎可能影響身體幾乎任何器官或系統。

      目前已知,發炎與幾乎所有人類重大疾病都有關聯,包括癌症、糖尿病、心血管疾病、多發性硬化症、自體免疫疾病,以及帕金森氏症和阿茲海默症等神經退化性疾病。估計美國有 2,350 萬人受到影響。

      推動耶魯的發炎研究

      十多年來,BFF 持續推動耶魯的生物醫學創新。這筆最新補助延續了基金會長期以來的慷慨支持,鼓勵富有創意的科學研究,揭示人體生物學的基本原理,並促進研究成果的轉譯應用。

      BFF 持續支持耶魯的發炎科學研究,已促成多項進展,從揭示調控發炎的基本原理,到理解腸道、免疫系統與大腦之間的系統性交互作用。

      Blavatnik Family Foundation 創辦人 Len Blavatnik 表示:「耶魯大學醫學院的傑出科學家具備獨特優勢,能在發炎科學領域取得突破。我們很榮幸能支持他們的努力,推動嶄新且整合性的研究,促進人類健康。」

      先驅研究者領軍全新發炎研究計畫

      這項計畫將由一群研究人員共同領導。免疫生物學 Sterling 講座教授 Ruslan Medzhitov(哲學博士)曾在先天免疫系統研究方面做出開創性發現,將擔任計畫主持人。

      Medzhitov表示:「我自 2007 年獲頒首屆 Blavatnik Award for Young Scientists 時便認識 Len Blavatnik,對基金會持續的支持尤其感激。這筆新補助將帶來重大改變。這類慈善支持日益重要,能讓我們進行富有創意、風險較高的研究,而這類研究往往受限於聯邦研究經費僵化的資助制度。」

      Medzhitov 將與幾位 YSM 同事共同領導計畫,包括:免疫生物學教授 Noah Palm(哲學博士),研究重點為微生物相如何形塑免疫健康。兒科及免疫生物學副教授 Liza Konnikova(醫學博士、哲學博士),是一位整合新生兒醫學、生命早期免疫,以及黏膜組織免疫系統研究專長的醫師科學家。免疫生物學 Sterling 講座教授 Akiko Iwasaki(哲學博士),研究涵蓋病毒如何永久改變免疫系統的機制,包括引發 COVID-19 的病毒。

      Palm解釋:「這筆補助將支持我們最新的研究工作,繪製連結腸道與大腦的細胞與分子通路圖譜,包括了解人體微生物相產生的小分子如何影響遠端組織的免疫反應。」

      耶魯研究團隊如何探索發炎在人類疾病中的作用

      多年來,發炎研究主要以特定疾病為背景。這種方法雖然有價值,卻也限制了研究人員發現看似無關的疾病背後所共有的基本原理。YSM 研究人員將發炎本身視為獨立的研究主題,而不只是疾病的衍生現象,藉此釐清發炎如何影響整體健康,並開拓新的科學研究領域。

      這項計畫將集結 YSM 內細胞生物學、生理學、神經科學及遺傳學等領域的專家,共同探究基礎問題。研究將聚焦於感染、環境因素及微生物相如何影響免疫系統,並引發發炎反應,進而影響從胎兒發育到大腦健康等各個層面。

      這種合作精神正是該計畫使命的核心。Palm 表示:「得知這筆補助時,我非常振奮,也很高興能與密切合作的同事一同參與這項獨特的研究。這類慈善支持不可或缺,讓我們得以探索大膽的新方向,而這些方向無疑會被傳統資助單位認為風險過高。這類研究可能揭示腸道微生物、免疫系統與大腦健康之間新穎且出乎意料的分子層級連結,最終有望找出以腸道為治療標的的中樞神經系統疾病新療法。」

      透過全新發炎科學獎助計畫,培育未來科學領袖

      BFF 這筆補助的一項重要用途,是設立「Blavatnik Graduate and Postdoctoral Fellows」研究生與博士後研究員獎助計畫,建立專注於發炎科學的人才培育管道。

      Medzhitov 表示:「這筆補助不僅讓我們得以探索發炎生物學中大膽創新的構想,也將成為吸引新一代研究人才來到耶魯的重要助力。」

      Yale School of Medicine

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