Applied BioMath, LLC announces collaboration with Zymeworks Inc.

Jan 19, 2016, 14:50 ET from Applied BioMath, LLC

WINCHESTER, Mass., Jan. 19, 2016 /PRNewswire/ -- Applied BioMath, LLC ( today announced a collaboration with Zymeworks Inc. (, a leader in the development of bi-specific antibodies, to leverage Applied BioMath's proprietary analytical and predictive capabilities in quantitative systems pharmacology.   

Under the terms of the agreement, Applied BioMath will assist Zymeworks on multiple programs focusing on bi-specific antibody drug conjugate therapeutics for oncology. Applied BioMath's industry leading analytics and toolsets will enable both:

  • GLP toxicology studies, such as dose selection, design, time point collection, and interpretation of results, and
  • First-in-human dose predictions for IND filings

"We are very excited to be working with such an industry leader as Zymeworks who is pioneering new approaches to antibody drug conjugates that promise to revolutionize treatments in oncology," said Dr. John Burke, PhD. "Our rigorous approach to in silico modeling, which focuses on the biology, will provide Zymeworks with insight into disease pathomechanisms and pharmacology.  This insight will aid in the prediction of safe dose ranges in humans and therapeutic doses in patients, increasing the likelihood of clinical success."

About Applied BioMath

Applied BioMath ( helps biotech and pharmaceutical companies reduce late stage program attritions and accelerate best-in-class (BIC) drugs using quantitative methodologies.  Leveraging biology, high performance computing (HPC), proprietary technology and experience in pharma, Applied BioMath delivers biological insights proven to shorten project timelines, lower costs, and develop BIC drugs.  Applied BioMath's predictive capabilities, when tested in clinical trials, were demonstrated to be 10x more accurate than industry standards. For a complete list of our services and case studies of commercial applications of our approaches, please visit our website,

Applied BioMath and the Applied BioMath logo are trademarks of Applied BioMath, LLC.

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CONTACT: Kristen Zannella, 774-469-0085,

SOURCE Applied BioMath, LLC