Non-human primates remain one of the few translational models capable of bridging the gap between early discovery science and first-in-human trials. Their close physiological and genetic similarity to humans allows researchers to obtain safety and efficacy information that cannot yet be obtained using other available models alone — such as in vitro, in silico, or rodent. This opening session examines how NHP models function as a translational bridge from bench to bedside, why they continue to occupy a distinct place in drug development, and how their use is continually reassessed as alternative methods to NHP models advance.
The session traces the evolution of NHP use in translational science, from early toxicology studies to today's more targeted, disease-specific applications across oncology, neuroscience, infectious disease, and metabolic research. Panelists will examine the role NHPs can play in preclinical research, including safety and efficacy assessments, comparing their strengths and limitations with emerging alternatives such as organ-on-chip systems and computational or AI-driven models, with concrete examples of where each approach adds genuine value and where meaningful gaps still remain. The discussion will also explore how researchers evaluate opportunities to replace, reduce and refine animal use, and how scientific, ethical and regulatory considerations inform study design. A dedicated case study will walk through the findings of a real pre-clinical program that relied on NHP models, illustrating how the data generated informed downstream clinical decisions and ultimately shaped the trajectory of a therapeutic programme.
Aimed at a life sciences audience but framed to remain accessible to non-specialists, the discussion will address the scientific, ethical, and regulatory considerations that shape how and when NHP models are used, and where the field is heading as new approach methodologies (NAMs) continue to mature and regulatory expectations evolve. The panel will also explore how researchers and sponsors weigh model selection decisions in practice, balancing scientific rigour, animal welfare, regulatory expectations, timelines, and cost.
Attendees will leave with a clearer, evidence-based picture of where NHPs continue to play a role within modern biomedical research, how that role is evolving alongside advances in NAMs and other emerging technologies, and how responsible, transparent, science-led decision-making supports scientific progress and public trust. The session will provide pratical insight relevant to R&D strategy and investment decisions in a field facing growing public and regulatory scrutiny.
Join Gourav Roy-Choudhury, PhD, DABT, Senior Director, Toxicology, Franklin Biolabs; Thierry Decelle, DVM, MSc, DipVetLAS, Founder & CEO, DCL Solutions; and Andrea Varrone, MD, PhD, Professor of Molecular PET, Department of Clinical Neuroscience, Karolinska Institutet, for the live webinar on Friday, September 25, 2026, at 11am EDT (5pm CEST / EU-Central).
For more information, or to register for this event, visit Assessing the Use of Non-Human Primates in Translational Research Today.
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