Biotech Briefing: Advancing Biotechs Forging Ahead With Breaking News Developments: Alliqua, OncoMed Pharmaceuticals, EnteroMedics, Unilife, Amarin

CORAL SPRINGS, Florida, December 4, 2013 /PRNewswire/ --

Biotechs develop new products and making an impact in the healthcare sector: Alliqua. Inc. (OTCQB: ALQAD), OncoMed Pharmaceuticals, Inc. (NASDAQ: OMED), EnteroMedics Inc. (NASDAQ: ETRM), Unilife Corporation (NASDAQ: UNIS) and Amarin Corporation plc (NASDAQ: AMRN)  

Alliqua, Inc. (OTCQB:ALQAD) has appointed Perry A. Karsen to its Board of Directors, increasing the size of the Board to nine members.  Mr. Karsen, age 58, is Chief Executive Officer of Celgene Cellular Therapeutics, a wholly owned subsidiary of Celgene Corporation, for which Mr. Karsen also serves as Executive Vice President and Chief Operations Officer.

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Mr. Karsen said, "Last month, I was pleased to help oversee the licensing of advanced wound care products, Biovance^® and Extracellular Matrix (ECM), from Celgene Cellular Therapeutics to Alliqua. I am impressed by Alliqua's existing suite of wound care products and I look forward to working with Alliqua's management as Alliqua expands its sales, marketing and distribution initiatives."  

OncoMed Pharmaceuticals, Inc. (NASDAQ: OMED) and Celgene Corporation (NASDAQ: CELG) recently announced an agreement to jointly develop and commercialize up to six anti-cancer stem cell (CSC) product candidates from OncoMed's biologics pipeline, including demcizumab (OMP-21M18, Anti-DLL4). OncoMed will control and conduct initial clinical studies at which point Celgene has an option to license worldwide rights to up to six novel anti-CSC therapeutic candidates. OncoMed retains global co-development and U.S. co-commercialization rights for five of the six anti-CSC product candidates with 50/50 U.S. profit sharing, and royalties to be received in other territories. Celgene will also have research, development and commercialization rights to small molecule compounds in an undisclosed cancer stem cell pathway.  

EnteroMedics Inc. (NASDAQ: ETRM) the developer of medical devices using neuroblocking technology to treat obesity, metabolic diseases and other gastrointestinal disorders, has announced 18 month efficacy and safety results from its 5 year ReCharge Pivotal Trial of VBLOC^® vagal blocking therapy for the treatment of obesity.  Patients in the VBLOC group (n=117), achieved excess weight loss (EWL) of 25%, or 10% total body weight loss (TBL), compared to 12% EWL, or 4% TBL for sham control group patients (n=42). The 13% difference in EWL demonstrated statistical superiority over sham control (p < 0.001). In total, 54% of patients in the VBLOC group achieved at least 20% EWL and 41% achieved at least 25% EWL, compared to 26% and 17%, respectively, for the sham control group at the 18-month interval. Significantly, approximately 78% of the patients who reported for their 18-month visit remained under the clinical trial's randomized blind.   

Unilife Corporation (NASDAQ: UNIS) recently announced an agreement with Novartis to supply clinical products from one of its platforms of injectable drug delivery systems for use with one of Novartis' targeted early-stage pipeline drugs. Under this agreement, Unilife will supply Novartis with a customized delivery device, consisting of syringe, needle, tubing, controller and pump, to enable administration of a novel investigational Novartis drug into a targeted organ in clinical trials. Unilife has granted Novartis an option for exclusivity under this agreement. The program to supply customized products for clinical use with Novartis drug candidates is the next phase in a development collaboration between the parties that was commenced in 2011, and continues to progress successfully. Under this agreement Unilife will generate revenue on the basis of the clinical product supplies and activities involved in clinical development.  

Amarin Corporation plc (NASDAQ: AMRN)  a biopharmaceutical company focused on the commercialization and development of therapeutics to improve cardiovascular health, announced today that the United States Patent and Trademark Office (USPTO) has published notification of a Notices of Allowance for Amarin's U.S. Patent Applications Serial Numbers 13/685,281, and 13/685,291, each titled "Stable Pharmaceutical Composition and Methods of Using Same." The claims in these allowed applications cover methods of lowering triglycerides by administering a pharmaceutical composition comprised of a mixture of free fatty acids, including EPA and/or DHA to varying degrees, to patients with severe hypertriglyceridemia (the MARINE population) and in patients with hypertriglyceridemia on concomitant statin therapy (the ANCHOR population). A Notice of Allowance is issued after the USPTO makes a determination that a patent can be granted from an application. The issued patents would have terms that expire no earlier than in 2030.

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