Can Vitamin D Work Without Magnesium?

LOS ANGELES, Oct. 8, 2014 /PRNewswire/ -- Extensive research has shown that vitamin D deficiencies play a major role in the development of dozens of diseases, including breast, prostate and colon cancer, as well as diabetes, heart disease, arthritis, osteoporosis, psoriasis and mental illness.

While many people are beginning to realize the health benefits that vitamin D has to offer in the prevention of disease, they may not be getting the full benefits from vitamin D without also supplementing their diets with magnesium.

According to Carolyn Dean, MD, ND, magnesium expert and Medical Advisory Board member of the nonprofit Nutritional Magnesium Association (www.nutritionalmagnesium.org), "Magnesium is a vital nutrient because it converts vitamin D into its active form.

"The effectiveness and benefits of vitamin D are greatly undermined in the absence of adequate levels of magnesium in the body. Magnesium acts with and is essential to the activity of vitamin D, and yet most Americans do not get their recommended daily allowance (RDA) of this important mineral."

Nutrients act in a synergetic way in the body. Absorption and metabolism of a particular nutrient will be affected, to a greater or lesser degree, by the other nutrients available to the body. This is also true of vitamin D.

According to the nonprofit Vitamin D Council, "In order to receive the most health benefit from increased levels of vitamin D, the proper cofactors must be present in the body. Vitamin D has many cofactors, but the ones listed here are the most important, with magnesium topping the list: Magnesium, Vitamin K, Vitamin A, Zinc and Boron."

The importance of magnesium as a nutrient required for proper vitamin D metabolism has been recognized by several studies published in the journal Magnesium Research, with the following findings:

• Magnesium is essential for the metabolism of vitamin D.
• Magnesium influences the body's utilization of vitamin D by activating cellular enzyme activity.^1,2
• Enzymes are protein molecules that stimulate every chemical reaction in the body. All the enzymes that metabolize vitamin D require magnesium.
• Magnesium has a possible role in vitamin D's effect on the immune system.³

Another study published in the European Journal of Pediatrics states: "Low magnesium has been shown to alter, by way of decreasing, production of vitamin D's active form...."⁴

Several studies related to bone health published in the Journal of Physiological Biochemistry and in the Clinical Nutrition journal point out that magnesium is also necessary for vitamin D's beneficial actions on bone.^5,6

"Vitamin D inhibits calcium deposition in arteries, and magnesium converts vitamin D into its active form so that it can prevent calcium buildup into cholesterol plaque in arteries. The combination of magnesium and vitamin D helps prevent clogged arteries by drawing calcium out of the blood and soft tissues back into the bones where it is needed to build healthy bone structure and prevent osteoporosis, some forms of arthritis and kidney stones," notes Dr. Dean.

A 32-page guide to the benefits of magnesium, along with magnesium deficiency symptoms, written by Dr. Dean, is available as a free download at www.nutritionalmagnesium.org.

For media inquiries, please contact Boris Levitsky at (714) 773-2695.

About the Nutritional Magnesium Association

The nonprofit Nutritional Magnesium Association (NMA) is a trusted authority on the subject of magnesium and is a resource for all people affected by the widespread magnesium deficiency in our diets and the related health issues associated with this deficiency.
For more information, go to www.nutritionalmagnesium.org.

References:

1. Zofková I, Kancheva RL. The relationship between magnesium and calciotropic hormones. Magnes Res. 1995 Mar; 8 (1): 77–84.
2. Carpenter TO. Disturbances of vitamin D metabolism and action during clinical and experimental magnesium deficiency. Magnes Res. 1988 Dec; 1 (3–4): 131–39.
3. McCoy H, Kenney MA. Interactions between magnesium and vitamin D: possible implications in the immune system. Magnes Res. 1996 Oct; 9 (3): 185–203.
4. Saggese G, Bertelloni S, Baroncelli GI, Federico G, Calisti L, Fusaro C. Bone demineralization and impaired mineral metabolism in insulin-dependent diabetes mellitus. A possible role of magnesium deficiency. Helv Paediatr Acta. 1989 Jun; 43 (5–6): 405–14.
5. Risco F, Traba ML. Bone specific binding sites for 1,25(OH)2D3 in magnesium deficiency. J Physiol Biochem. 2004 Sep; 60 (3): 199–203.
6. Risco F, Traba ML, de la Piedra C. Possible alterations of the in vivo 1,25(OH)2D3 synthesis and its tissue distribution in magnesium-deficient rats. Magnes Res. 1995 Mar; 8 (1): 27–35.

SOURCE Nutritional Magnesium Association