Complete Genomics unveils DNBSEQ-T1+ and DNBSEQ-E25 Flash at AGBT 2025 General Meeting

MARCO ISLAND, Fla., Feb. 24, 2025 /PRNewswire/ -- Complete Genomics, a leading innovator in genomic sequencing, today unveiled its latest high-performance sequencing solutions at the 2025 Advances in Genome Biology and Technology (AGBT) General Meeting. The newly introduced DNBSEQ-T1+* and DNBSEQ-E25 Flash* are designed to deliver speed, flexibility, and efficiency, empowering researchers with faster, high-quality genomic data.

DNBSEQ-T1+: Mid-Throughput Sequencing with Industry-Leading Speed

The DNBSEQ-T1+ is a next-generation mid-throughput sequencer that completes a paired end 150 sequencing workflow in just 24 hours with Q40 accuracy. With three flow cell formats, two to four addressable lanes on each flow cell, along with dual independent flow cell operation, the DNBSEQ-T1+ provides increased data output with reduced turnaround time which enables increased lab efficiency and flexibility. With a throughput range of 25–1,200 Gb, a maximum capacity exceeding 1 Tb daily, DNBSEQ-T1+ allows laboratories to reduce the time to result that is important in a range of laboratory settings. The DNBSEQ-T1+ integrated auto-DNB making and loading capabilities enables a straightforward, user-friendly workflow. This design offers the flexibility to process multiple samples independently without requiring barcodes, leverage independent flow cell lanes and start the sequencing workflow in less than ten minutes with minimal hands-on time.

"The DNBSEQ-T1+ brings a new level of efficiency, output and cost to mid-throughput sequencing, offering output and pricing typical of previous higher output systems while providing laboratories the speed and flexibility needed for a wide range of genomic applications - such as Whole Genome Sequencing, Single Cell, Spatial, Oncology, Rare Disease and Metagenomics - all within a streamlined, user-friendly workflow," said Rob Tarbox, VP of Product and Marketing at Complete Genomics.

The newly launched DNBSEQ-T1+ mid-throughput sequencer joins the established DNBSEQ-T7 high-throughput, DNBSEQ-G99 and DNBSEQ-E25 low-throughput platforms in achieving sub-24-hour sequencing run times for PE150 read lengths. The 24-hour sequencing framework across the sequencing portfolio enables laboratories to maximize their output while retaining flexibility and control across various laboratory settings.

In addition, the DNBSEQ-T1+ has optimized the internal design of the instrument, significantly reducing the number of reagents required for sequencing. Additionally, coupled with high-density flow cells, DNBSEQ-T1+ has reduced the cost per Gb. This allows laboratories, even small or mid-sized, to achieve the cost per Gb of a production-scale sequencer when using this benchtop sequencer. DNBSEQ-T1+ is currently available for pre-order globally.

DNBSEQ-E25 Flash: AI-Enhanced Sequencing in Under Two Hours

The DNBSEQ-E25 Flash is an upgraded instrument from its existing portable DNBSEQ-E25 sequencer. It redefines portable sequencing with AI-driven enhancements. Building on self-luminescence technology and a CMOS-based flow cell, this next-generation sequencer leverages AI-optimized protein engineering for enhanced signal intensity and precision.

An AI-powered base calling system deployed on an edge device powered by the NVIDIA Jetson platform accelerates sequencing to new speeds. A single-substrate injection eliminates the need for traditional dual-luciferase systems, reducing cycle times to just one minute and enabling SE50 sequencing in under two hours.

Complete Genomics at AGBT 2025

Complete Genomics will host a variety of activities at AGBT 2025 to celebrate its introduction of two new products, including live instrument demos, morning presentations in Suite Osprey 6, and a Bronze 4 workshop talk. Attendees can explore the power of DNBSEQ-T1+ and DNBSEQ-E25 Flash for applications including clinical WGS, WES, single-cell sequencing, spatial transcriptomics, and infectious disease.

Leveraging NVIDIA Parabricks, rapid analysis benchmarking can be performed on data from DNBSEQ-T1+, DNBSEQ-T7, and DNBSEQ-G400 using GPU acceleration.

Jason Fenwick from NVIDIA will present on benchmarking Parabricks workflows on DNBSEQ platforms and discuss the utilization of NVIDIA's RAPIDS libraries and the Rapids-singlecell library from scverse in STOmics spatial transcriptomics analysis.

Bronze 4 Workshop: Advancing Genomics Discoveries with DNBSEQ-T1+

Location: Calusa Ballroom 1-7

Date: Feb. 25 | 3:20 - 3:35 p.m.
Speaker: Piotr Mieczkowski, Ph.D., Professor, UNC Chapel Hill

For the full AGBT 2025 schedule, visit www.completegenomics.com/agbt2025

About Complete Genomics

Complete Genomics has been a leader in high-throughput, cost-effective sequencing technology since 2005. With more than 9,400 publications, its innovative sequencing solutions continue to advance genomic research worldwide.

* For Research Use Only. Not for use in diagnostic procedures.

SOURCE Complete Genomics